DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and FES

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001996.1 Gene:FES / 2242 HGNCID:3657 Length:822 Species:Homo sapiens


Alignment Length:474 Identity:168/474 - (35%)
Similarity:241/474 - (50%) Gaps:68/474 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 TSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVR---------ILSYNKSGEWCEAH 247
            |..|:|   ||.|..|.|.:.        :::.|....||.|         ||..:.||.:....
Human   386 TKLEHL---GPGEPPPVLLLQ--------DDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKF 439

  Fly   248 SDSGNVGWVPSNYVTPLNSLEKHSWYHGPISR-NAAEYLLSSGINGSFLVRESESSPGQRSISLR 311
            |....:..:|.    ....|.:..||||.|.| ..||.|:.|   |.||||||:... :..:|:.
Human   440 SLPPPLQLIPE----VQKPLHEQLWYHGAIPRAEVAELLVHS---GDFLVRESQGKQ-EYVLSVL 496

  Fly   312 YEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHG------LITPLL---YPAPKQ 367
            ::|...|:.|.             ..:.|..|        ||.|      ||..||   .|..|:
Human   497 WDGLPRHFIIQ-------------SLDNLYRL--------EGEGFPSIPLLIDHLLSTQQPLTKK 540

  Fly   368 NKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVK----TLKEDTMALK 428
            :...:....|: |:|.:...|:::..::|.|.:|||:....:.....||||    ||..|..|  
Human   541 SGVVLHRAVPK-DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA-- 602

  Fly   429 DFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQ 493
            .||:||.|:|:..|||:|:||||||::.|.||:.|.:..|:.|.|||:.|.. |....||.|...
Human   603 KFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGD 666

  Fly   494 IASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAK-FPIKWTAPEG 557
            .|:||.||||:..||||||||||||.:..::|::|||::|...|..|.|..|.: .|:||||||.
Human   667 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEA 731

  Fly   558 LAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQC 622
            |.|.::|::||||:||:||||..:.|.||||.:........::||.|:..|..||..|:.||.||
Human   732 LNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 796

  Fly   623 WQWDATDRPTFKSIHHALE 641
            |.::...||:|.:|:..|:
Human   797 WAYEPGQRPSFSTIYQELQ 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 11/62 (18%)
SH2_ABL 268..363 CDD:198189 30/104 (29%)
PTKc_Abl 382..644 CDD:270645 115/265 (43%)
FABD 1584..1723 CDD:197885
FESNP_001996.1 Important for interaction with membranes containing phosphoinositides 1..300
F-BAR_Fes 7..239 CDD:153369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..421 7/34 (21%)
SH2_Fps_family 453..537 CDD:198224 31/108 (29%)
PTKc_Fes 564..815 CDD:270667 112/253 (44%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.