Protein Alignment Abl and Syk

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_035648.2
• Gene: Syk / 20963
• MGIID: 99515
• Length: 629
• Species: Mus musculus
• Alignment Length: 645
• Identity: 189/645 - (29%)
• Similarity: 282/645 - (43%)
• Gaps: 168/645 - (26%)

  Fly   103 GLNIFTEHNGTKHSSFRGHPGKYHMNLEALLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGL 167
            |..:...||...|          |..:|..|..   .:..:|..|.:..||..  ..|.|:..||
Mouse    49 GFALSVAHNRKAH----------HYTIERELNG---TYAISGGRAHASPADLC--HYHSQEPDGL 98

  Fly   168 ------------GLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGG 220
                        |:|         ..|..||..     ||||:.        :.....::.|...
Mouse    99 ICLLKKPFNRPPGVQ---------PKTGPFEDL-----KENLIR--------EYVKQTWNLQGQA 141

  Fly   221 ENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAE-- 283
            ..|..:.:..|:..|...      .||                    ||..|:||.|||:.:|
Mouse   142 LEQAIISQKPQLEKLIAT------TAH--------------------EKMPWFHGNISRDESEQT 180

  Fly   284 YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHS 348
            .|:.|..||.||:|..::| |..::.|.:||:|.||||..|..||:.:.:..||:||.:||.|:|
Mouse   181 VLIGSKTNGKFLIRARDNS-GSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYS 244

  Fly   349 -----------VPHE------GH--------------GLITPL---LYPAPKQNKPT-------- 371
                       ||.:      ||              |:|:.:   .:|.|...||.
Mouse   245 YKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYSFPKPGHKKPAPPQGSRPE 309

  Fly   372 ------------------------VFPL------SPEPDEWEICRTDIMM--------KHKLGGG 398
                                    ..|:      ||..|..||...::.:        .::||.|
Mouse   310 STVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLDRSLLTLEDNELGSG 374

  Fly   399 QYGEVYEAVW--KRYGNTVAVKTLKEDT--MALKD-FLEEAAIMKEMKHPNLVQLIGVCTREPPF 458
            .:|.|.:..:  |:...|||||.||.:.  .|||| .|.||.:|:::.:|.:|::||:|..| .:
Mouse   375 NFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE-SW 438

  Fly   459 YIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKL 523
            .::.|....|.|..:|:. .|...|. .::.:..|::.||.|||..|::||||||||.|:.....
Mouse   439 MLVMEMAELGPLNKYLQQ-NRHIKDK-NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY 501

  Fly   524 VKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSP 586
            .|::||||::.:|.|.  |.|....|:|:||.|||.:.|.|||:|||||:||||:||..:||..|
Mouse   502 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKP 566

  Fly   587 YPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQE 646
            |..:..::|...|:||.||..|.|||.|:||||..||.:|..:||.|.::...|.:.:.:
Mouse   567 YRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRLRNYYYD 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	6/53 (11%)
		SH2_ABL	268..363	CDD:198189	43/130 (33%)
		PTKc_Abl	382..644	CDD:270645	108/276 (39%)
		FABD	1584..1723	CDD:197885
Syk	NP_035648.2	SH2_N-SH2_Zap70_Syk_like	12..115	CDD:198191	17/89 (19%)
		Interdomain A	107..166		17/106 (16%)
		SH2_C-SH2_Syk_like	163..261	CDD:198264	39/98 (40%)
		Interdomain B	259..364		14/104 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..328		4/34 (12%)
		PTKc_Syk	370..625	CDD:133247	106/257 (41%)