Protein Alignment Abl and Ripk1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_033094.3
• Gene: Ripk1 / 19766
• MGIID: 108212
• Length: 656
• Species: Mus musculus
• Alignment Length: 775
• Identity: 165/775 - (21%)
• Similarity: 267/775 - (34%)
• Gaps: 251/775 - (32%)

  Fly   380 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKD--FLEEAAIMKEMKH 442
            |..::..:|::.|..|..|.:|:|.....:.:|..:..|.......|..:  .|||..:|..::|
Mouse     8 DNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRH 72

  Fly   443 PNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS--------AGRETLDAVALLYMATQIASGMS 499
            ..:|:|:|:...|..:.::.|:|..|||:..|::        .||..::|:          .||.
Mouse    73 SRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAI----------EGMC 127

  Fly   500 YLESRNYIHRDLAARNCLVGDNKLVKVADFGLARL-------------MRDDTYTAHAGAKFPIK 551
            ||..:..||:||...|.||..:..:|:||.|:|..             .::.:.|........:.
Mouse   128 YLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLY 192

  Fly   552 WTAPEGL--AYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERP------ 608
            :.|||.|  ...|.:.||||::||::||.|.. ...||..:..|:.:....|.  ..||
Mouse   193 YMAPEHLNDINAKPTEKSDVYSFGIVLWAIFA-KKEPYENVICTEQFVICIKS--GNRPNVEEIL 254

  Fly   609 PGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSG 673
            ..||.|:..||.:|||....|||||..|.... ..|..|...|.||:    :..|.....|..|.
Mouse   255 EYCPREIISLMERCWQAIPEDRPTFLGIEEEF-RPFYLSHFEEYVEE----DVASLKKEYPDQSP 314

  Fly   674 VATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETG 738
            |.    ....:....|         :.|.|.......||
Mouse   315 VL----QRMFSLQHDC---------VPLPPSRSNSEQPG-------------------------- 340

  Fly   739 STSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLS 803
                  |..||||   :||             .|...|..|||.:....|.|
Mouse   341 ------SLHSSQG---LQM-------------GPVEESWFSSSPEYPQDEND------------- 370

  Fly   804 TNGIHKLKTANYFSQTLSRNFKTQI---PTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQ 865
                              |:.:.::   .::|...|..::|.:.|..|.:..          :::
Mouse   371 ------------------RSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAY----------NRE 407

  Fly   866 QQKQQQYSIKKSSSCSSFLYDILFRGLARD-INSLTQRYDSETDPAADPDTDATGDSLEQSLSQV 929
            ::::::.|           :|...:..||: |.|...|..|      ||.|.:.|.:::|
Mouse   408 EERKRRVS-----------HDPFAQQRARENIKSAGARGHS------DPSTTSRGIAVQQ----- 450

  Fly   930 IAAPVTNKM-------QHSLHSGGGGGGIGPRSSQQHSSFKRPT-------GTPVM--------- 971
            ::.|.|..:       ||...:.|.|....|..||.:|::|.|.       .||.|
Mouse   451 LSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVAD 515

  Fly   972 --------GNRGLETRQSKRSQ--LHSQAPGP--GPPSTQPHHG---NNGVVTSAH--PI----- 1014
                    .:.|::........  |:||.|..  ...||..|..   |...:|..|  ||
Mouse   516 DLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLG 580

  Fly  1015 ------------TVGALDVMN-----------VKQVVNRY----GTLPKGARIGAYLDSL 1047
                        |...:|.::           |.|::.::    ||  |||.:|....:|
Mouse   581 RQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGT--KGATVGKLAQAL 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	78/292 (27%)
		FABD	1584..1723	CDD:197885
Ripk1	NP_033094.3	Protein Kinases, catalytic domain	23..291	CDD:473864	77/281 (27%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546	291..567		70/403 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..373		19/124 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..423		6/55 (11%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682	520..536		1/15 (7%)
		Death_RIP1	568..653	CDD:260048	15/73 (21%)