DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and abl-1

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_509778.2	Gene:	abl-1 / 181261	WormBaseID:	WBGene00000018	Length:	1224	Species:	Caenorhabditis elegans

Alignment Length:	1635	Identity:	472/1635 - (28%)
Similarity:	682/1635 - (41%)	Gaps:	576/1635 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 SSTTSVFESAHRWTSKENLLA----------------PGPEEDDPQLFVALYDFQAGGENQLSLK 227
            :|.:|.|..:.   |:|:|:|                .........||||||||...||.||||:
Worm    76 NSDSSTFRGSQ---SREDLVACSSMNSVNNVHDMNTVSSSSSSSAPLFVALYDFHGVGEEQLSLR 137

  Fly   228 KGEQVRILSYNKSGEWCEAHSDS------------GNVGWVPSNYVTPLNSLEKHSWYHGPISRN 280
            ||:|||||.|||:.|||||...|            |.:||||||::.|.|||:|::||||.|||:
Worm   138 KGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFIAPYNSLDKYTWYHGKISRS 202

  Fly   281 AAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVH 345
            .:|.:|.|||.|||||||||:|.||.:||:|::|||:||||:.|...|:|:|||.||.||.||||
Worm   203 DSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGELVH 267

  Fly   346 HHSVPHEGHGLITPLLYPAPKQNKPT-VFPLSPE-PDEWEICRTDIMMKHKLGGGQYGEVYEAVW 408
            ||||  ...|||..|:|||.|::|.. :|.|||. |||||:.|::|:|.:||||||||:|||..|
Worm   268 HHSV--HADGLICLLMYPASKKDKGRGLFSLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYW 330

  Fly   409 KRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDF 473
            ||:..|:|||.||||.|.|.:||.||||||::.|.|||:|:||||.|.|||||||||.:||||::
Worm   331 KRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEY 395

  Fly   474 LRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDD 538
            ||...:..|..:.|:.||:||||||||||:|::||||||||||||.::.:||:|||||||.|::|
Worm   396 LRRTDKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKED 460

  Fly   539 TYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGY 603
            |||||||||||||||||||||:|.||:|||||||||||||||||||:|||.::|::||..|:.|:
Worm   461 TYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGF 525

  Fly   604 RMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSSA 668
            ||:.|.||||.||.||.|||.|..:|||.|:.||..||::...:|:.:.|:|||..|
Worm   526 RMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLISSNSLNDEVQKQLKKN-------- 582

  Fly   669 PSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTP 733
                                                                  ||
Worm   583 ------------------------------------------------------ND--------- 584

  Fly   734 MSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNF 798
                    .||.  |.:.:.||:.|..                  |.||.|::.:.
Worm   585 --------KKLE--SDKRRSNVRERSD------------------SKSRHSSHHDR--------- 612

  Fly   799 IDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAH 863
              |.....:|            |||...:||..
Worm   613 --DRDRESLH------------SRNSNPEIPNR-------------------------------- 631

  Fly   864 QQQQKQQQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQ 928
                              ||:                                .|.||:
Worm   632 ------------------SFI--------------------------------RTDDSV------ 640

  Fly   929 VIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPG- 992
                                            ||..|:.|            ||.:...:|.|.
Worm   641 --------------------------------SFFNPSTT------------SKVTSFRAQGPPF 661

  Fly   993 PGPP--STQPHHGNNGVVTSAHPIT----------VGALDVMNVKQVVNRY-GTLPKGARIGAYL 1044
            |.||  :|:|....:.:.::|...:          |..|...||::.|.|. ||:|||.||.|||
Worm   662 PPPPQQNTKPKLLKSVLNSNARHASEEFERNEQDDVVPLAEKNVRKAVTRLGGTMPKGQRIDAYL 726

  Fly  1045 DSL------EDSSEAAPALPATAPSLPPANGHATPPAARL--NPKASPIP-PQQMIRSNSSGGVT 1100
            ||:      ::|::|            ...|..:...:|.  |.....:| |..|   |||..|.
Worm   727 DSMRRVDSWKESTDA------------DNEGAGSSSLSRTVSNDSLDTLPLPDSM---NSSTYVK 776

  Fly  1101 MQNNAAASL------NKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFP 1159
            |...:..::      :||::...|.|  :....|..|..::.|.|.....:..      :::::|
Worm   777 MHPASGENVFLRQIRSKLKKRSETPE--LDHIDSDTADETTKSEKSPFGSLNK------SSIKYP 833

  Fly  1160 PPPLDLPPPPEEFEG----GPPPPPPAPESAVQAIQQHLHAQLPNNGNIS---NGNGTNNNDSSH 1217
                 :...||..|.    .|.|.||:                 .|.::|   :....:::|.:.
Worm   834 -----IKNAPEFSENHSRVSPVPVPPS-----------------RNASVSVRPDSKAEDSSDETT 876

  Fly  1218 NDVSNIAPSVEEASSRFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLANG 1282
            .||....|                                 |..:..:|:....|:.|     |.
Worm   877 KDVGMWGP---------------------------------KHAVTRKIEIVKNDSYP-----NV 903

  Fly  1283 SGIAVVDPVSLLVTEL-AESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVEPKKMSAPMPKAEP 1346
            .|            || |:..||...|.::       ::|.|            :...|:...:.
Worm   904 EG------------ELKAKIRNLRHVPKEE-------SNTSS------------QEDLPLDATDN 937

  Fly  1347 ANTII-----DFKAHLRRVDKEKEPATPAPAPATVAVANNANCNTTGTLNRKEDGSKKFSQAMQK 1406
            .|..|     |.||.:|::..:|........|.::...||   :|:..::..|...
Worm   938 TNDSIIVIPRDEKAKVRQLVTQKVSPLQHHRPFSLQCPNN---STSSAISHSEHAD--------- 990

  Fly  1407 TEIKIDVTNSNVEADAGAAGE---GDLGKRRSTGSINSLKKLWEQQPPAPDYATSTILQQQPSVV 1468
                    :|...:.:|...|   .:|.::||.|....:...|                    ::
Worm   991 --------SSETSSLSGVYEERMKPELPRKRSNGDTKVVPVTW--------------------II 1027

  Fly  1469 NGGGTPNAQLSPK----YGMKSGAINTVGTLPAKLGNKQPPAAPPPPPPNCTTSNSSTTSISTSS 1529
            ||...||.....|    ...|...:.|..|:.:|:....|
Worm  1028 NGEKEPNGMARTKSLRDITSKFEQLGTASTIESKIEEAVP------------------------- 1067

  Fly  1530 RDCTSRQQASSTIKTSHSTQLFTDDEEQSHTEGLGSGGQGSADMTQSLYEQKPQIQQKPAVPHKP 1594
                .|:.|.....||....:.....|..|                             .||  |
Worm  1068 ----YREHALEKKGTSKRFSMLEGSNELKH-----------------------------VVP--P 1097

  Fly  1595 TKLTIYATPIAKLTEPASSASSTQISRESILELVGLLEGSLKHPVNAIAGS--------QWLQLS 1651
            .|        .:..:.:.|.....:|::.|:.|:.:::....:..| :|.|        |::.::
Worm  1098 RK--------NRNQDESGSIDEEPVSKDMIVSLLKVIQKEFVNLFN-LASSEITDEKLQQFVIMA 1153

  Fly  1652 DKLNILHNSCVIFAENGAMPPHSKFQFRELVTRVEAQSQHLR---SAGSKNVQDNERLVAEVGQS 1713
            |.:..||::|.::||.  :.|||||:|:||::::|..::.::   :..:|.|.|..::..:  ..
Worm  1154 DNVQKLHSTCSVYAEQ--ISPHSKFRFKELLSQLEIYNRQIKFSHNPRAKPVDDKLKMAFQ--DC 1214

  Fly  1714 LRQISNALNR 1723
            ..||...::|
Worm  1215 FDQIMRLVDR 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	37/65 (57%)
		SH2_ABL	268..363	CDD:198189	57/94 (61%)
		PTKc_Abl	382..644	CDD:270645	174/261 (67%)
		Pkinase_Tyr	389..640	CDD:285015	169/250 (68%)
		FABD	1584..1723	CDD:197885	32/149 (21%)
abl-1	NP_509778.2	SH3_Abl	119..185	CDD:212784	37/65 (57%)
		SH2_ABL	190..283	CDD:198189	57/94 (61%)
		PTKc_Abl	304..566	CDD:270645	174/261 (67%)
		Pkinase_Tyr	311..562	CDD:285015	169/250 (68%)
		FABD	1091..1224	CDD:197885	33/176 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161037
Domainoid	1	1.000	370	1.000	Domainoid score	I477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	680	1.000	Inparanoid score	I367
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto19239
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.890