Protein Alignment Abl and nck-1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001361996.1
• Gene: nck-1 / 180690
• WormBaseID: WBGene00006410
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 252
• Identity: 78/252 - (30%)
• Similarity: 110/252 - (43%)
• Gaps: 61/252 - (24%)

  Fly   164 SGGLGLQGS--------SLGGGHSSTTSVFESAHRWTSKENLLAPGPE------EDDPQLFVALY 214
            :||:|...|        |..|...|..:...:|....:...:.||.|:      ..:.|:.||||
 Worm   158 NGGVGWFPSNYVEEVEASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEIQVVVALY 222

  Fly   215 DFQAGGENQLSLKKGEQVRILSY-NKSGEWCEAHSDSGNVGWVPSNYVTPLNS------------ 266
            .|.|....:||.||||::.|:.: ....:|..|.:.||..|.||.||:..:|.
 Worm   223 SFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVVNDSSSSKASHQDFA 287

  Fly   267 ----------LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 321
                      :|:..||.|.|||..||.||..|..|.||||:|||:||..|||:|...|..|:::
 Worm   288 PQYSGNGEIPMEQQPWYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIERNKHFKV 352

  Fly   322 SEDPDG------KVFVTQEAKFNTLAELVHHH------SVPHEGHGLITPLLYPAPK 366
             ::.||      :.||...|       |::|:      |.|.|...|..||    ||
 Worm   353 -QNVDGLLKIGNRTFVDMNA-------LINHYTTSPIFSSPTEKLFLTGPL----PK 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	22/54 (41%)
		SH2_ABL	268..363	CDD:198189	41/106 (39%)
		PTKc_Abl	382..644	CDD:270645
		FABD	1584..1723	CDD:197885
nck-1	NP_001361996.1	SH3_Nck_1	5..55	CDD:212699
		SH3_Nck_2	118..171	CDD:212700	4/12 (33%)
		SH3_Nck_3	217..272	CDD:212701	22/54 (41%)
		SH2_Nck_family	301..392	CDD:198196	37/98 (38%)