Protein Alignment Abl and kin-24

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_501761.2
• Gene: kin-24 / 177829
• WormBaseID: WBGene00002206
• Length: 516
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 145/574 - (25%)
• Similarity: 234/574 - (40%)
• Gaps: 119/574 - (20%)

  Fly   241 GEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQ 305
            ||.||...:....|.|.::.|..|..      |||...:.....|:.....|:||.|......|.
 Worm     4 GEACEKSQEKTFTGSVGNSRVHNLKC------YHGVQKKEEVANLMRGERPGTFLFRSCFVKSGV 62

  Fly   306 R-----SISLR---YEGRVYHYRISEDPDGKVF-----------VTQEAK-FNTLAELVHHHSVP 350
            .     |:.:|   .:..::||:: ||..|:.:           ||:|:| |.||.||:.|
 Worm    63 ALALFLSVKVRAGDSDANIHHYQV-EDRAGEYYLMQELMEKEELVTRESKAFPTLEELIGH---- 122

  Fly   351 HEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKH--KLGGGQYGEVYEAVWKRYGN 413
            .:.|.|...:     :..:|...|      .|::....::...  |||.|.:..||..:.::.|.
 Worm   123 FQHHRLACKI-----RLGRPLKRP------SWQLRHNSVVYDDTGKLGSGNFCIVYRGMLRKQGK 176

  Fly   414 --TVAVKTLK---EDTMALKD----FLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGN 469
              .||:|..|   :::.||.:    .|.||.||....:.|::::.||....|||.:..||.|.|:
 Worm   177 IIPVAIKVSKNSDKESAALMETRNLLLAEARIMMNYNNINVIRIYGVACDVPPFMVCMEFCSGGS 241

  Fly   470 LLDFLRSAGR--ETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLA 532
            |.|.|:..|:  |..:...||..|   |.||.||..:..:|||||:||||:..:.:||:|||||:
 Worm   242 LEDALKKYGKDMEEFERQILLIDA---ARGMRYLHDKKCVHRDLASRNCLISFDGIVKIADFGLS 303

  Fly   533 R-LMRDDTYTAHAGAKFPIKWTAPEGL-AYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDV 595
            : |.:|......|..:.|:.|.|||.: ..::||||:|||||||:::|:.......:...:...:
 Worm   304 KTLEKDQKAFKEALKEAPLAWLAPECIQRESEFSTKTDVWAFGVVIFEVYNNAEKLFAGEEDIAI 368

  Fly   596 YHKLDKGYRMERPPGCP--------PEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEA 652
            ..|:.|.       ..|        |.:..::...|.....|||..:.:...|..........:.
 Worm   369 LRKIKKA-------NMPTIENRTKVPAMQAVLSSIWTRKPDDRPEMQKVLEKLVAALVPIQPDDL 426

  Fly   653 VEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMV--------KKG 709
            ...|:|:....:.:..|:|                      .....:|:..:.|        :|.
 Worm   427 KRLQINSLKGVSRTQMPNT----------------------DLEMDVSVVNEEVDQDGSEKNRKV 469

  Fly   710 LPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNK 763
            ..|.:..|.|.|:....:    ||..|.          |.:.|..|.:|.|..|
 Worm   470 KGGSKKKTGNRHNRSGKR----TPKQEE----------SPKSKKPVPLRNTVRK 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	7/21 (33%)
		SH2_ABL	268..363	CDD:198189	28/114 (25%)
		PTKc_Abl	382..644	CDD:270645	87/284 (31%)
		FABD	1584..1723	CDD:197885
kin-24	NP_501761.2	SH2	29..128	CDD:214585	27/109 (25%)
		STYKc	157..414	CDD:214568	85/266 (32%)