DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and C55C3.4

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_500846.1 Gene:C55C3.4 / 177346 WormBaseID:WBGene00016954 Length:431 Species:Caenorhabditis elegans


Alignment Length:451 Identity:141/451 - (31%)
Similarity:208/451 - (46%) Gaps:70/451 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQ-RSISLRYEGR----VYHYRISEDPDGKVFV 331
            :|||.:.|...:.:|:.  .|.||:|.||...|: |...|...|.    ..|:.:.| .|.||:|
 Worm    11 YYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKNTSANHFVVRE-ADHKVYV 72

  Fly   332 TQEAKFNTLAELVHHHSVPHEG----HGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMK 392
             .:..|.|:.|||:|:....|.    .|.:..:|..|.::.|            ||:...|:.:.
 Worm    73 -DKIGFPTIIELVNHYVSTKESFSTKDGTVKVVLKHAVERQK------------WELYHEDVELT 124

  Fly   393 HKLGGGQYGEVYEAVWKRYGN------------TVAVKTLKEDTMA---LKDFLEEAAIMKEMKH 442
            .|||.|.:||    |||  |.            .|||||.|.::|.   :|:.:.||.:|:.:.|
 Worm   125 KKLGEGAFGE----VWK--GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183

  Fly   443 PNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYI 507
            .|:|:..||.....|.|:|.|....|.|...|.......:....|:|   |.|:|::|:..:|.:
 Worm   184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY---QAANGLAYIHEKNLM 245

  Fly   508 HRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAF 572
            |||:||||||.|..: ||:|||||:|...|  ||.....|.||:|..||.:....::.|:||:||
 Worm   246 HRDVAARNCLYGGGQ-VKIADFGLSREGAD--YTMDLKKKVPIRWLPPETIRSGLYTPKTDVFAF 307

  Fly   573 GVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYD-LMRQCWQWDATDRPTFKSI 636
            ||:.|||...|..|||...:.:|..|:.:||||...|....|..: ::.:||.....||...|.|
 Worm   308 GVMAWEITEDGKEPYPGFKVIEVAMKVLQGYRMPFSPEVNKEFAEFILTKCWPEKYEDRLPMKDI 372

  Fly   637 HHALEHMFQESSI------------TEAVEKQLNANATSASSSAPSTSGVATGGGATTTTA 685
                 ..:.:||:            .....|::..:.:..|.|..||...|.|......||
 Worm   373 -----CKWMKSSVKAQGGDTGPGGMMSKFGKKIKRSNSRESKSKSSTMTAAHGHDQGAMTA 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189 30/99 (30%)
PTKc_Abl 382..644 CDD:270645 98/277 (35%)
FABD 1584..1723 CDD:197885
C55C3.4NP_500846.1 SH2_Fps_family 4..93 CDD:198224 27/85 (32%)
TyrKc 121..376 CDD:197581 95/271 (35%)
Blue background indicates that the domain is not in the aligned region.

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