Protein Alignment Abl and zak-1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001367790.1
• Gene: zak-1 / 175954
• WormBaseID: WBGene00006971
• Length: 745
• Species: Caenorhabditis elegans
• Alignment Length: 874
• Identity: 174/874 - (19%)
• Similarity: 316/874 - (36%)
• Gaps: 246/874 - (28%)

  Fly   365 PKQNKPT-----------VFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVK 418
            |..|:.|           :||        :|.|.||.:...:|.|.:|.|:...|
 Worm     4 PTSNESTSSSSNNSDQRVLFP--------DIQRDDIQVGDHIGVGTFGAVFSGNW---------- 50

  Fly   419 TL---KEDTMALKDFL---EEAAIMKEMKHPNLVQLIGVC-TREPPFYIITEFMSHGNLLDFLR- 475
            ||   .:.|:|||...   :||.|:.:::|.|::|..|:| .....|:|:||:...|:|.||:.
 Worm    51 TLPDGSQRTIALKKVFVLEKEAEILSKIRHKNIIQFYGICKATGNDFFIVTEYAEKGSLYDFIHS 115

  Fly   476 --------SAGRETLDAVALLYMATQIASGMSYLESRNY------IHRDLAARNCLVGDNKLVKV 526
                    |:|..:.|.|  :..|:|||||:.||   :|      |||||.::|.::..|.:.|:
 Worm   116 EESQSFASSSGGNSFDVV--VKWASQIASGIQYL---HYDAVDTIIHRDLKSKNVVLDKNLVCKI 175

  Fly   527 ADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNK-FSTKSDVWAFGVLLWEIATYGMSPYPA 589
            .|||.:: |....|..:..|.   ..|.:||.:..:: .:|.:|||::||:||||.:..: ||..
 Worm   176 CDFGTSKDLTHSCTAPSWGGT---AAWMSPEMILQSEGLTTATDVWSYGVVLWEILSKEV-PYKD 236

  Fly   590 IDLTDVYHKL-DKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAV 653
            .....::..: ..|..:..||.||..:..||..||:....||...:.|...|..:.....:.:..
 Worm   237 YSEFRIFTMITQSGITLAIPPSCPAPLKQLMSNCWKMTPKDRANMRQIQGELNRLAGNQKVMDEC 301

  Fly   654 EKQLNAN--ATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQAL 716
            ||.:...  .|.......:...:.              .........|.:..:.:|:.:...||:
 Worm   302 EKFMGLEDWKTEIEKQEKNVEKMR--------------KDLEKRREQLEIREKALKQRMKVEQAV 352

  Fly   717 TPNAHH--NDPHQ--QQASTPMSET--GSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRT 775
            ..:|.|  .|.||  :..::...||  |..:.. ..|..:....|...|.|..:
 Worm   353 LDSARHPPEDVHQWSEHHTSHWVETVLGRVAND-KKFLDRVNAAVFRNRITGAR----------- 405

  Fly   776 SLLSSSRDSTYREEDPANARCNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQ 840
             ||..::                 :||...|:||:.:.....:.:.:...||...|:...:
 Worm   406 -LLGMTQ-----------------NDLEHLGVHKVGSRIELMKMIRKLADTQKALHNFPTL---- 448

  Fly   841 QQQQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLYD----ILFRGL-ARDINSLT 900
                                    :|.|:.:.::|.....:..|.:    ::..|: .|.:|:..
 Worm   449 ------------------------EQAKRIEMTLKTEKEAAGQLANDVDIVIIVGMYVRKMNATR 489

  Fly   901 QRYDSETDPAADPDTDATGDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRP 965
            :::....|.....|||....|..:..|.:|.....:.:..:.                    |:|
 Worm   490 RKFKFYADSDWIDDTDIPAKSKSKHASSLIKTVCFSVLDENT--------------------KKP 534

  Fly   966 TGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNR 1030
            ...|....                              ::|:.|:...|||...|.:.::.:|:.
 Worm   535 INEPACSI------------------------------SSGMTTNPDWITVDTEDDVKIRVIVSV 569

  Fly  1031 Y----GTLPKGARIGAYLDSLEDS--------------SEAAPALPATAPSLPPA--------NG 1069
            |    .|.|:...:...:.|||:|              |.::.::...:|.:.|.        ||
 Worm   570 YYADIVTQPRNTEVIKVVTSLEESKILEERHVHLRLRRSSSSASISTPSPVIAPVYHPFGHLNNG 634

  Fly  1070 -HATPPAARL-----------------NPKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRHR 1116
             |.|..:.:|                 ..:.|.:  |:.:|:.|.....:..|....:.||.|.|
 Worm   635 FHHTTSSPQLRGFWHRKQTGMNRHGLTETELSSL--QEQLRTPSPDKKVVDENVIIHVPKLTRRR 697

  Fly  1117 TTTEGTMMTFSSFRAGGSSSSPKRSASGV 1145
            .||  |..:..:.::..::.:|:..|..|
 Worm   698 RTT--TTNSEDTEKSDTNNKTPESQARRV 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	86/286 (30%)
		FABD	1584..1723	CDD:197885
zak-1	NP_001367790.1	Protein Kinases, catalytic domain	38..291	CDD:473864	82/271 (30%)