DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Grap2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_034945.1 Gene:Grap2 / 17444 MGIID:1333842 Length:322 Species:Mus musculus


Alignment Length:198 Identity:60/198 - (30%)
Similarity:95/198 - (47%) Gaps:39/198 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 ALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGP 276
            |.:||.|.||::||.:.|:.::|||..:  ||.:|...| ..|:||.|::    .:|...|:|..
Mouse     5 AKFDFMASGEDELSFRTGDILKILSNQE--EWLKAELGS-QEGYVPKNFI----DIEFPEWFHEG 62

  Fly   277 ISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLA 341
            :||:.||.||.....|.|::|.|:||||..|||:|:|..|.|:::..|..|..|:..| ||.:|.
Mouse    63 LSRHQAENLLMGKDIGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDTKGNYFLWTE-KFPSLN 126

  Fly   342 ELVHHH---------------SVPHEGH----------------GLITPLLYPAPKQNKPTVFPL 375
            :||.::               ....:||                |.:...:.|:..:......||
Mouse   127 KLVDYYRTTSISKQKQVFLRDGTQDQGHRGNSLDRRSQGGPHPSGTVGEEIRPSVNRKLSDHLPL 191

  Fly   376 SPE 378
            .|:
Mouse   192 GPQ 194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 20/50 (40%)
SH2_ABL 268..363 CDD:198189 36/125 (29%)
PTKc_Abl 382..644 CDD:270645
FABD 1584..1723 CDD:197885
Grap2NP_034945.1 SH3 2..53 CDD:473055 20/54 (37%)
SH2_Grb2_like 54..147 CDD:199828 33/93 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..216 7/52 (13%)
SH3_GRAP2_C 267..319 CDD:212883
Blue background indicates that the domain is not in the aligned region.

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