DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Lck

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001155904.1 Gene:Lck / 16818 MGIID:96756 Length:520 Species:Mus musculus


Alignment Length:463 Identity:209/463 - (45%)
Similarity:285/463 - (61%) Gaps:29/463 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   195 ENLLAP-GPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHS-DSGNVGWVP 257
            |..|.| .|.:|:  |.:||:.::...:..|..:||||:|||  .:||||.:|.| .:|..|::|
Mouse    63 EGSLPPASPLQDN--LVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIP 123

  Fly   258 SNYVTPLNSLEKHSWYHGPISRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRV 316
            .|:|...||||...|:...:||..|| .||:.| .:||||:|||||:.|..|:|:|    .:|.|
Mouse   124 FNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEV 188

  Fly   317 Y-HYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSP-EP 379
            . ||:|....:|..:::....|..|.:||.|::  :...||.|.|..|...|.     |..| ..
Mouse   189 VKHYKIRNLDNGGFYISPRITFPGLHDLVRHYT--NASDGLCTKLSRPCQTQK-----PQKPWWE 246

  Fly   380 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRY--GNT-VAVKTLKEDTMALKDFLEEAAIMKEMK 441
            ||||:.|..:.:..:||.||:||    ||..|  |:| ||||:||:.:|:...||.||.:||:::
Mouse   247 DEWEVPRETLKLVERLGAGQFGE----VWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQ 307

  Fly   442 HPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNY 506
            ||.||:|..|.|:| |.|||||:|.:|:|:|||::.....|:...||.||.|||.||:::|.:||
Mouse   308 HPRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY 371

  Fly   507 IHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWA 571
            |||||.|.|.||.|....|:||||||||:.|:.|||..||||||||||||.:.|..|:.|||||:
Mouse   372 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWS 436

  Fly   572 FGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSI 636
            ||:||.||.|:|..|||.:...:|...|::||||.||..||.|:|.||..||:....|||||..:
Mouse   437 FGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYL 501

  Fly   637 HHALEHMF 644
            ...|:..|
Mouse   502 RSVLDDFF 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 22/54 (41%)
SH2_ABL 268..363 CDD:198189 37/101 (37%)
PTKc_Abl 382..644 CDD:270645 135/264 (51%)
FABD 1584..1723 CDD:197885
LckNP_001155904.1 SH3_Lck 76..129 CDD:212938 22/54 (41%)
SH2_Src_Lck 134..234 CDD:198225 37/101 (37%)
PTKc_Lck_Blk 248..511 CDD:270652 137/267 (51%)
Blue background indicates that the domain is not in the aligned region.

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