DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and Fer

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001033086.2 Gene:Fer / 14158 MGIID:105917 Length:823 Species:Mus musculus


Alignment Length:519 Identity:182/519 - (35%)
Similarity:259/519 - (49%) Gaps:100/519 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 TAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGP---EEDDP 207
            |.|...|..|.|:|..|::.|                           ||    |.|   .|:|.
Mouse   373 TEAKCAAQKALLEQKVQENDG---------------------------KE----PPPVVNYEEDA 406

  Fly   208 QLFVALYDFQAGGENQLSLKKGEQVR-----ILSYNK-----SGEWCEAHSDSGNVGWVPSNYVT 262
            :...::       |.:..|.|.|.:|     |:...|     |.:.|:..|    ||..|     
Mouse   407 RSVTSM-------ERKERLSKFESIRHSIAGIIKSPKSVLGSSTQVCDVIS----VGERP----- 455

  Fly   263 PLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDG 327
                |.:|.||||.|.|..|:.||..  .|.||||||...||:..:|:..:|:..|:.|.     
Mouse   456 ----LAEHDWYHGAIPRIEAQELLKQ--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQ----- 509

  Fly   328 KVFVT-----QEAKFNTLAELVHHH----SVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWE 383
              ||.     :...|:.:.:|:.||    .|..:..|::  ||.|.||..|            |.
Mouse   510 --FVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVV--LLNPIPKDKK------------WV 558

  Fly   384 ICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKED-TMALK-DFLEEAAIMKEMKHPNLV 446
            :...|:.:...||.|.:||||:...|. ...||:||.||| ...|| .||:||.|:|:..|||:|
Mouse   559 LNHEDVSLGELLGKGNFGEVYKGTLKD-KTPVAIKTCKEDLPQELKIKFLQEAKILKQYDHPNIV 622

  Fly   447 QLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDL 511
            :||||||:..|.|||.|.:..|:.|.|||.. ::.|....|:..:..:|:||.||||:|.|||||
Mouse   623 KLIGVCTQRQPVYIIMELVPGGDFLTFLRKR-KDELKLKQLVRFSLDVAAGMLYLESKNCIHRDL 686

  Fly   512 AARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLL 576
            ||||||||:|..:|::|||::|......|::....:.||||||||.|.|.::|::||||:||:||
Mouse   687 AARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILL 751

  Fly   577 WEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL 640
            ||..:.|:.|||.:.......::::||||..|..||.||:.:|.:||.:...:||.|..:|..|
Mouse   752 WETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEVFTIMMKCWDYKPENRPKFNDLHKEL 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 13/63 (21%)
SH2_ABL 268..363 CDD:198189 33/103 (32%)
PTKc_Abl 382..644 CDD:270645 117/261 (45%)
FABD 1584..1723 CDD:197885
FerNP_001033086.2 Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250 1..300
F-BAR_Fer 5..238 CDD:153370
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..408 8/49 (16%)
SH2_Fps_family 454..539 CDD:198224 31/102 (30%)
Protein Kinases, catalytic domain 567..817 CDD:473864 115/251 (46%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.