Protein Alignment Abl and Csk

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_031809.2
• Gene: Csk / 12988
• MGIID: 88537
• Length: 450
• Species: Mus musculus
• Alignment Length: 445
• Identity: 182/445 - (40%)
• Similarity: 261/445 - (58%)
• Gaps: 28/445 - (6%)

  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHS---- 271
            :|.|:|....|..|...||:.:.|::..|...|.:|.:..|..|.:|:|||.....::..:
Mouse    15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSL 79

  Fly   272 --WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQE 334
              |:||.|:|..||.||.....|.||||||.:.||..::.:..||:|.||||.... .|:.:.:|
Mouse    80 MPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHA-SKLSIDEE 143

  Fly   335 AKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE-----WEICRTDIMMKHK 394
            ..|..|.:||.|::.  :..||.|.|:  .||..:.||    ...||     |.:...::.:...
Mouse   144 VYFENLMQLVEHYTT--DADGLCTRLI--KPKVMEGTV----AAQDEFYRSGWALNMKELKLLQT 200

  Fly   395 LGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREP-PF 458
            :|.|::|:|....::  ||.||||.:|.|..| :.||.||::|.:::|.|||||:||...|. ..
Mouse   201 IGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGL 262

  Fly   459 YIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKL 523
            ||:||:|:.|:|:|:|||.||..|....||..:..:...|.|||..|::||||||||.||.::.:
Mouse   263 YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV 327

  Fly   524 VKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYP 588
            .||:||||.   ::.:.|...| |.|:||||||.|...|||||||||:||:|||||.::|..|||
Mouse   328 AKVSDFGLT---KEASSTQDTG-KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388

  Fly   589 AIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHM 643
            .|.|.||..:::|||:|:.|.||||.||::|:.||..||..||||..:...|||:
Mouse   389 RIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHI 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	17/51 (33%)
		SH2_ABL	268..363	CDD:198189	36/100 (36%)
		PTKc_Abl	382..644	CDD:270645	123/263 (47%)
		FABD	1584..1723	CDD:197885
Csk	NP_031809.2	Interaction with PTPN22. /evidence=ECO:0000269|PubMed:8890164	9..70		17/54 (31%)
		SH3_CSK	11..67	CDD:212703	17/51 (33%)
		SH2_csk_like	78..175	CDD:198190	38/101 (38%)
		PTKc_Csk	188..443	CDD:133213	122/261 (47%)