DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and Btk

DIOPT Version :9

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_038510.2 Gene:Btk / 12229 MGIID:88216 Length:659 Species:Mus musculus


Alignment Length:490 Identity:192/490 - (39%)
Similarity:281/490 - (57%) Gaps:38/490 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 SAHRWTSKENLLAPGPEED---------DP----------QLFVALYDFQAGGENQLSLKKGEQV 232
            |:||.|.|.  |.|.||||         :|          :..|||||:.....|.|.|:|||:.
Mouse   179 SSHRKTKKP--LPPTPEEDQILKKPLPPEPTAAPISTTELKKVVALYDYMPMNANDLQLRKGEEY 241

  Fly   233 RILSYNKSGEWCEAHSDSGNVGWVPSNYVTPL-NSLEKHSWYHGPISRNAAEYLL-SSGINGSFL 295
            .||. ..:..|..|...:|..|::||||:|.. :|:|.:.||...::|:.||.|| ..|..|.|:
Mouse   242 FILE-ESNLPWWRARDKNGQEGYIPSNYITEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFI 305

  Fly   296 VRESESSPGQRSISL------RYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGH 354
            ||:| |..|:.::|:      ..:|.:.||.:...|..:.::.::..|:|:.||:::|.  |...
Mouse   306 VRDS-SKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQ--HNSA 367

  Fly   355 GLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWK-RYGNTVAVK 418
            |||:.|.||..||||............|||...|:....:||.||:|.|....|: :|  .||:|
Mouse   368 GLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQY--DVAIK 430

  Fly   419 TLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLD 483
            .::|.:|:..:|:|||.:|..:.|..||||.||||::.|.:||||:|::|.||::||.. |....
Mouse   431 MIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQ 494

  Fly   484 AVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKF 548
            ...||.|...:...|.||||:.::|||||||||||.|..:|||:||||:|.:.||.||:..|:||
Mouse   495 TQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKF 559

  Fly   549 PIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPP 613
            |::|:.||.|.|:|||:|||:||||||:|||.:.|..||.....::....:.:|.|:.||.....
Mouse   560 PVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE 624

  Fly   614 EVYDLMRQCWQWDATDRPTFK-SIHHALEHMFQES 647
            .||.:|..||...|.:||:|| .:.:.|:.|.:||
Mouse   625 RVYTIMYSCWHEKADERPSFKILLSNILDVMDEES 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 21/53 (40%)
SH2_ABL 268..363 CDD:198189 31/101 (31%)
PTKc_Abl 382..644 CDD:270645 117/263 (44%)
Pkinase_Tyr 389..640 CDD:285015 112/252 (44%)
FABD 1584..1723 CDD:197885
BtkNP_038510.2 PH_Btk 6..166 CDD:269944
Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250 12..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 171..210 12/32 (38%)
SH3_BTK 217..271 CDD:212839 21/54 (39%)
SH2_Tec_Btk 274..378 CDD:198260 34/106 (32%)
PTKc_Btk_Bmx 397..652 CDD:173657 114/257 (44%)
Inhibitor-binding. /evidence=ECO:0000250 474..479 3/4 (75%)
CAV1-binding. /evidence=ECO:0000250 581..588 6/6 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1047190at2759
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

Return to query results.
Submit another query.