DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Blk

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_031575.2 Gene:Blk / 12143 MGIID:88169 Length:499 Species:Mus musculus


Alignment Length:499 Identity:207/499 - (41%)
Similarity:286/499 - (57%) Gaps:48/499 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 SSTTSVFESAHRWTSKE-----------------NLLAPGPEEDDP----QLFVALYDFQAGGEN 222
            ||...|.|....|:..:                 |.|||.....||    :..|||:|:.|..:.
Mouse     5 SSKRQVSEKGKGWSPVKIRTQDKAPPPLPPLVVFNHLAPPSPNQDPDEEERFVVALFDYAAVNDR 69

  Fly   223 QLSLKKGEQVRILSYNKSGEWCEAHS-DSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL 286
            .|.:.|||::::|  ..:|:|..|.| .:|..|:||||:|.|:.:||...|:...|||..||..|
Mouse    70 DLQVLKGEKLQVL--RSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQL 132

  Fly   287 SSGIN--GSFLVRESESSPGQRSISLR---YEGRVY-HYRISEDPDGKVFVTQEAKFNTLAELVH 345
            .:.:|  ||||:|||||:.|..|:|::   .:|.|. ||:|....:|..:::....|.||..||.
Mouse   133 LAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEVVKHYKIRSLDNGGYYISPRITFPTLQALVQ 197

  Fly   346 HHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPE----PDEWEICRTDIMMKHKLGGGQYGEVYEA 406
            |:|  .:|.||...|..|...        |:|:    .|||||.|..:.:..|||.||:|||:..
Mouse   198 HYS--KKGDGLCQKLTLPCVN--------LAPKNLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMG 252

  Fly   407 VWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLL 471
            .:|. ...||:|||||.||:.:.||.||.:||.::|..||:|..|.||| |.||:||:|:.|.||
Mouse   253 YYKN-NMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTRE-PIYIVTEYMARGCLL 315

  Fly   472 DFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMR 536
            |||::.....|....|:.|:.|:|.||:|:|..|.|||||.|.|.||.:....|:|||||||:: 
Mouse   316 DFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII- 379

  Fly   537 DDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDK 601
            |..|||..||||||||||||.:.:..|:.|:|||:|||||.||.|||..|||.:...:|...|:.
Mouse   380 DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEH 444

  Fly   602 GYRMERPPGCPPEVY-DLMRQCWQWDATDRPTFKSIHHALEHMF 644
            ||||..|..||||:| |::.:||:....:||||:.:...||..:
Mouse   445 GYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFY 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 21/54 (39%)
SH2_ABL 268..363 CDD:198189 38/100 (38%)
PTKc_Abl 382..644 CDD:270645 130/262 (50%)
FABD 1584..1723 CDD:197885
BlkNP_031575.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 5/28 (18%)
SH3 56..109 CDD:473055 21/54 (39%)
SH2_Src_Blk 114..213 CDD:198234 38/100 (38%)
Protein Kinases, catalytic domain 227..490 CDD:473864 131/265 (49%)
Blue background indicates that the domain is not in the aligned region.

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