DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and Abl1

DIOPT Version :9

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001106174.1 Gene:Abl1 / 11350 MGIID:87859 Length:1142 Species:Mus musculus


Alignment Length:1285 Identity:515/1285 - (40%)
Similarity:655/1285 - (50%) Gaps:313/1285 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 GSGSGLSQRSGGHKDARCNPTVGLNIFTEHNGTKHSSFRGHPGKYHMNLEALLQSRPLPHIPAGS 145
            |:|...|.|.||   ..|      |:|.||                   |||  .||:       
Mouse    25 GAGKRDSSRHGG---PHC------NVFVEH-------------------EAL--QRPV------- 52

  Fly   146 TAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLF 210
                    |::.:.          ||.|             .|.||.||||||| ||.|:||.||
Mouse    53 --------ASDFEP----------QGLS-------------EAARWNSKENLLA-GPSENDPNLF 85

  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHG 275
            ||||||.|.|:|.||:.|||::|:|.||.:||||||.:.:|. |||||||:||:|||||||||||
Mouse    86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSWYHG 149

  Fly   276 PISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTL 340
            |:||||||||||||||||||||||||||||||||||||||||||||:...|||::|:.|::||||
Mouse   150 PVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTL 214

  Fly   341 AELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYE 405
            ||||||||...:  ||||.|.|||||:||||::.:||..|:||:.||||.|||||||||||||||
Mouse   215 AELVHHHSTVAD--GLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYE 277

  Fly   406 AVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNL 470
            .|||:|..||||||||||||.:::||:|||:|||:||||||||:||||||||||||||||::|||
Mouse   278 GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNL 342

  Fly   471 LDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM 535
            ||:||...|:.:.||.||||||||:|.|.|||.:|:|||||||||||||:|.|||||||||:|||
Mouse   343 LDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM 407

  Fly   536 RDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLD 600
            ..|||||||||||||||||||.|||||||.|||||||||||||||||||||||.|||:.||..|:
Mouse   408 TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE 472

  Fly   601 KGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSAS 665
            |.||||||.|||.:||:|||.||||:.:|||:|..||.|.|.|||||||::.|||:|....|...
Mouse   473 KDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGG 537

  Fly   666 S----SAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMV-KKGLPGGQALTPNAHHNDP 725
            :    .||..        .|.|......|....|..    ||::: .|||....||         
Mouse   538 AGSMLQAPEL--------PTKTRTCRRAAEQKDAPD----TPELLHTKGLGESDAL--------- 581

  Fly   726 HQQQASTPM---SETGSTSTKLSTFSSQGKGNVQMRRTTN-------KQGKQAPAPPKRTSL--- 777
            ..:.|.:|:   .|.|.....|    ::.:..:...|.||       |:.|.||.||||:|.   
Mouse   582 DSEPAVSPLLPRKERGPPDGSL----NEDERLLPRDRKTNLFSALIKKKKKMAPTPPKRSSSFRE 642

  Fly   778 LSSSRDSTYREEDPANARCNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQ 842
            :....|.....||.:...||....|:::.....|:....:.....|...:.|.:  ...|:....
Mouse   643 MDGQPDRRGASEDDSRELCNGPPALTSDAAEPTKSPKASNGAGVPNGAFREPGN--SGFRSPHMW 705

  Fly   843 QQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLY-----DILFRG--LARDINSLT 900
            ::.|.        |:..:.|..:::.....|.:...|||:...     |..:|.  |.||:.|..
Mouse   706 KKSST--------LTGSRLAAAEEESGMSSSKRFLRSCSASCMPHGARDTEWRSVTLPRDLPSAG 762

  Fly   901 QRYDSETDPAADPDTDA-----TGDSLEQSLSQVIAAP---VTNKMQHSLHSGGGGGGIGPRSSQ 957
            :::||.|......:..|     |.:|..:.:::..|.|   :..|.:.:...|            
Mouse   763 KQFDSSTFGGHKSEKPALPRKRTSESRSEQVAKSTAMPPPRLVKKNEEAAEEG------------ 815

  Fly   958 QHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVM 1022
                ||             :|..|         ||..|||..|                      
Mouse   816 ----FK-------------DTESS---------PGSSPPSLTP---------------------- 832

  Fly  1023 NVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNPKASPIPP 1087
               :::.|..|    |...:.|...|::::.:            |:|..||..      |.|.||
Mouse   833 ---KLLRRQVT----ASPSSGLSHKEEATKGS------------ASGMGTPAT------AEPAPP 872

  Fly  1088 QQMIRSNSSGGVTMQNNAAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPA 1152
                 ||..|    .:.|::...:::||:                .||.||.|.        :..
Mouse   873 -----SNKVG----LSKASSEEMRVRRHK----------------HSSESPGRD--------KGR 904

  Fly  1153 LANLEFPPPPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNN---- 1213
            ||.|: |.||   |||....:.|.|...|:.|:.                  ..|..|...    
Mouse   905 LAKLK-PAPP---PPPACTGKAGKPAQSPSQEAG------------------EAGGPTKTKCTSL 947

  Fly  1214 --DSSHNDVSNIAPSVEEASSRFGVSLRKR-EPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAP 1275
              |:.:.|.:...|.        |..|||. .||.....|...||......:.|      ..|||
Mouse   948 AMDAVNTDPTKAGPP--------GEGLRKPVPPSVPKPQSTAKPPGTPTSPVST------PSTAP 998

  Fly  1276 A-SHLANG---SGIAVVDPVSLLVTELAESMNLPKPPPQQQQKLTNGNST 1321
            | |.||..   |..|.:..:|..|     |:...:.||   :::.:|..|
Mouse   999 APSPLAGDQQPSSAAFIPLISTRV-----SLRKTRQPP---ERIASGTIT 1040

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 34/53 (64%)
SH2_ABL 268..363 CDD:198189 75/94 (80%)
PTKc_Abl 382..644 CDD:270645 201/261 (77%)
Pkinase_Tyr 389..640 CDD:285015 194/250 (78%)
FABD 1584..1723 CDD:197885
Abl1NP_001106174.1 SH3_Abl 84..137 CDD:212784 34/53 (64%)
SH2_ABL 142..235 CDD:198189 75/94 (80%)
PTKc_Abl 254..516 CDD:270645 201/261 (77%)
Pkinase_Tyr 261..512 CDD:285015 194/250 (78%)
FABD 1018..1142 CDD:197885 7/31 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 419 1.000 Domainoid score I645
eggNOG 1 0.900 - - E2759_KOG4278
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 786 1.000 Inparanoid score I517
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 1 1.000 - - otm44126
orthoMCL 1 0.900 - - OOG6_100013
Panther 1 1.100 - - LDO PTHR24418
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4932
SonicParanoid 1 1.000 - - X88
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.850

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