DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and Ttbk1

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_001156336.1	Gene:	Ttbk1 / 106763	MGIID:	2147036	Length:	1308	Species:	Mus musculus

Alignment Length:	1427	Identity:	301/1427 - (21%)
Similarity:	464/1427 - (32%)	Gaps:	352/1427 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLE-EAAIMKEMK-H 442
            |.|::.:       |:|||.:||:|||:.......||:|.  |.....|..|: |.|::|::: .
Mouse    32 DRWKVLK-------KIGGGGFGEIYEAMDLLTRENVALKV--ESAQQPKQVLKMEVAVLKKLQGK 87

  Fly   443 PNLVQLIGVCTREPPF-YIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNY 506
            .::.:.|| |.|...| |::.:.... ||.|..||..|.|......|.:..||...:..:.|..:
Mouse    88 DHVCRFIG-CGRNEKFNYVVMQLQGR-NLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 150

  Fly   507 IHRDLAARNCLVG----DNKLVKVADFGLARLMRDDTYTAH-----AGAKFPIKWTAPEGLAYNK 562
            :|||:...|..:|    ..:...:.||||||...:.|....     ||.:..:::.:.......:
Mouse   151 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNRE 215

  Fly   563 FSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGY--RMERPPGCPPEVYDLMRQCWQW 625
            .....|:|:...:|.|.|. |..|:..|...:....:.:.|  || .....|.|.:..:......
Mouse   216 MGRHDDLWSLFYMLVEFAV-GQLPWRKIKDKEQVGMIKEKYEHRM-LLKHMPSEFHLFLDHIASL 278

  Fly   626 DATDRPTFKSIHHALEHMFQESSITEAV----EKQLNANATSASSSAP---STSGVATGGGATTT 683
            |...:|.::.|....|:..:|..|.|..    ||.......|.|:|.|   :|...|...|....
Mouse   279 DYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNV 343

  Fly   684 TAASGCASSSSATASLS------------LTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSE 736
            |...|.....:....|.            :.|....:||..|..|.|  |...|..:    ...|
Mouse   344 TPVPGDLLRENTEDVLQGEHLSDQENAPPILPGRPPEGLGPGPHLVP--HPGGPEAE----VWEE 402

  Fly   737 TGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRT---SLLSSSRDSTYRE-EDPANARCN 797
            |.....||..    ..|..........:|...|:.|.|.   |..:..|...||. ..|.:.|
Mouse   403 TDVNRNKLRI----NIGKTPCVEEEQSRGVGVPSSPVRAPPDSPTTPVRSLCYRRVNSPESER-- 461

  Fly   798 FIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQA 862
                |||       .|:...:...|..:..:|...:.|..:.|..|..||            ...
Mouse   462 ----LST-------AADGRVELQERRSRMDLPGSPSRQACSSQPAQMLSV------------DTG 503

  Fly   863 HQQQQKQQQYSIKKSSSCSSFLYDILFRG--LARDINSLTQRY---DSETD-----PAADPDTDA 917
            |..:|...:..:  |:|.........||.  ||.:.:..::.:   |.||:     |.|:|.|..
Mouse   504 HADRQASGRMDV--SASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPSTSG 566

  Fly   918 TGDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKR------PTGTPVMGNRGL 976
            |.|...:.|..:   |...:.:..|   |....:.||....|:..:.      |...|.
Mouse   567 TTDEEPEELRPL---PEEGEERRRL---GTEPTVRPRGRGMHTLTEEDPRQMLPQPAPP------ 619

  Fly   977 ETRQSKRSQLHSQAPGPGPPSTQPHHG--------------NNGVVTSAHPITVG--------AL 1019
            :..|:......||.|.||.||..|.|.              ...|.:.|.|..|.        ||
Mouse   620 QLSQADGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQVFSVAPPFEVNGLPRAVPLAL 684

  Fly  1020 DVMNVKQVVNRY----GTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNP 1080
            ...:.|:.::.|    ..|.:..|:|     .......||.:| .||..|.|||...........
Mouse   685 PYQDFKRDLSDYRERARLLNRVRRVG-----FSHMLLTAPQVP-LAPFQPQANGKEGEEEEEEEE 743

  Fly  1081 KASPIPPQQMIRSNSSGGVTMQNNAAASLNKL--QRHRTTTEGTMMTFSSFRAGGSS---SSPKR 1140
            :......::............:...|.:|.::  .|..:::||:..:....:.|..|   :..::
Mouse   744 EEEEEEEEEEEEEEEEEEEEEEEEEAGALGEVLGPRSGSSSEGSERSTERSQEGAPSTLLADDQK 808

  Fly  1141 SASGVASGVQPALANLEFPP----------PPLDLPPPPEEFEGGPPP--------------PPP 1181
            .|.|.||     :|:.:..|          .|.|:...|...|..|.|              |.|
Mouse   809 EARGRAS-----MADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPDPDLGTLAALTPQHERPQP 868

  Fly  1182 A--------PESAVQAIQQHLHAQLPNNGN----ISNGNGTNNNDSSHNDVSNIAPSVEEAS--- 1231
            .        |.:....::.......|..|.    ::.|.|.....|....|......:.|.|
Mouse   869 TGSQLDVSEPGTLSSILKSEPKPSGPGAGGGVGLVAPGAGVTAVTSPFTKVERTFVHIAEKSHLN 933

  Fly  1232 --SRFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVDPVSLL 1294
              |..|.:.|..|.||.  ..||.  |.|.|..|.|      :.|||. |.||..:|.:|.
Mouse   934 VMSSGGQASRPEELSTG--GELGL--EVLSEGGIAE------EGAPAP-LENGMALAGLDG---- 983

  Fly  1295 VTELAESMNLPKPPPQQQQK-----LTNGNSTGSGFKAQLKKVEPKKMSAPMPKAEPA---NTII 1351
             ||: ||..|..||.:...:     |.||.:...|             .||..:.||.   .|.|
Mouse   984 -TEM-ESCALSGPPGETPSEVVTDSLPNGPALADG-------------PAPASQQEPVTKKGTTI 1033

  Fly  1352 DFKAHLRRVDKEKEPATPAPAPAT----VAVANNANCNTTGTLNRKEDGSKKFSQAMQKTEIKID 1412
            ....|          |.|...|.:    :....:.....:|:|:.||..||:.........:.::
Mouse  1034 SPSRH----------AMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWSKRARPQQDLARLVME 1088

  Fly  1413 VTNSN--VEADAGAAGEGDLGKRRS------TGS------------------------------I 1439
            .....  :...:||:......:||:      |||                              |
Mouse  1089 KRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPTTALPRKAVRAATTRSRIPRPI 1153

  Fly  1440 NSLKKLWEQQPP--------APDYATSTILQ-QQPSVVNGGGTPNAQLSPKYGMKSGAINTVGTL 1495
            :....:..||.|        |.|.|.::.|| |:||    |..|.|.|.||.....|.    |..
Mouse  1154 SVSMPVEGQQLPGRPHGAASATDLAITSRLQLQKPS----GLAPAADLRPKQSASRGP----GPG 1210

  Fly  1496 PAKLGNKQPPAAPPPPPPNCTTSNSSTTSISTSSRDCTSRQQASSTIKTSHSTQLFTDDEEQSHT 1560
            .|::..   ||||..|....:|:...:.|..:.|   .||:::||
Mouse  1211 RAQVSK---PAAPRSPGLPASTARHPSGSPRSQS---LSRKESSS-------------------- 1249

  Fly  1561 EGLGSGGQGSADMTQSLYEQKPQIQQKPAVPHKPTKLTIYATPIAKLTEPASSASSTQISRE 1622
                                 |..|.:|.||.....|.:.:.|.|....|.......|:..:
Mouse  1250 ---------------------PSHQARPGVPPSRGVLQVRSQPEASPVAPKKGPKGKQLQTQ 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	67/275 (24%)
		Pkinase_Tyr	389..640	CDD:285015	65/264 (25%)
		FABD	1584..1723	CDD:197885	9/39 (23%)
Ttbk1	NP_001156336.1	STKc_TTBK1	33..294	CDD:271032	66/273 (24%)
		PHA03307	324..>683	CDD:223039	82/407 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..397		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..448		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..671		45/222 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..899		31/184 (17%)
		PHA03307	963..>1305	CDD:223039	87/419 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	985..1085		26/123 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1308		50/249 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000