DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and txk

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	XP_003201292.4	Gene:	txk / 100534735	ZFINID:	ZDB-GENE-130530-553	Length:	509	Species:	Danio rerio

Alignment Length:	466	Identity:	179/466 - (38%)
Similarity:	265/466 - (56%)	Gaps:	15/466 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SKENLLAPGPEEDDPQLF--VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGW 255
            |::.|....|::||..:.  ||:|||.|...:.|:|.:||...|| :.:...|..|....||.|:
Zfish    51 SQKKLPRSPPDDDDNGVMKVVAMYDFTARESSDLTLHRGETYIIL-HKQDQLWWRAKDRHGNKGF 114

  Fly   256 VPSNYVTPLNSLEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRY-----EG 314
            :||||||...::|.:.||...|:|..||:|| ..|.:|.|:|| |.|.|...::|: |     :|
Zfish   115 IPSNYVTETGTIEANDWYCKNINRAEAEHLLRQEGKDGGFVVR-SSSQPSTYTVSV-YTHCSGKG 177

  Fly   315 RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 379
            .|.||:|....:.|.::.:...|.::.||:::|.  :...||:..|.||...:.|..........
Zfish   178 EVRHYQIKRTDEDKFYLAENHVFISIPELINYHK--YNAAGLVARLRYPIGPKGKCQPATAGFSS 240

  Fly   380 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPN 444
            |:.||..:::....:||.||:|.|....| |..:.||:||::|..|...||:|||.||..:.||.
Zfish   241 DKMEINPSELTFMKELGSGQFGVVRLGKW-RAQHKVAIKTIREGAMNEDDFIEEAKIMTRLCHPK 304

  Fly   445 LVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHR 509
            ||||.|||..:.|..|:||||.:|.||.|||...: ||....:|.|...:..||.|||...:|||
Zfish   305 LVQLYGVCVTQRPICIVTEFMENGCLLHFLRQHSK-TLGRSQMLCMCQDVCEGMEYLEHNQFIHR 368

  Fly   510 DLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGV 574
            |||||||||.:..:|||.|||:.|.:.|:.||:..|::||:||:.||.|.:||||.|||||:|||
Zfish   369 DLAARNCLVNERNVVKVCDFGMTRYVLDNQYTSSMGSRFPVKWSPPEVLHFNKFSNKSDVWSFGV 433

  Fly   575 LLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHA 639
            |:||:.:.|.:|:......:|..::.:|.|:.||....|.:|::|.:||......||.|..:...
Zfish   434 LMWEVFSEGKTPFDNRTNVEVVEEVTQGSRLYRPHLATPHIYNIMYRCWHERPHGRPAFSELLQD 498

  Fly   640 LEHMFQESSIT 650
            ...:.:|.:.|
Zfish   499 FRQITEEETDT 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	22/55 (40%)
		SH2_ABL	268..363	CDD:198189	32/100 (32%)
		PTKc_Abl	382..644	CDD:270645	113/261 (43%)
		Pkinase_Tyr	389..640	CDD:285015	111/250 (44%)
		FABD	1584..1723	CDD:197885
txk	XP_003201292.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920