DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and tec

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	XP_031751261.1	Gene:	tec / 100491653	XenbaseID:	XB-GENE-6076361	Length:	648	Species:	Xenopus tropicalis

Alignment Length:	460	Identity:	186/460 - (40%)
Similarity:	268/460 - (58%)	Gaps:	28/460 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 PGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVT-- 262
            |.||::..:..:|::||.....:.|.|..||:..:|. .|...|.:|.:..|..|::||||||
Frog   196 PEPEDNGEETVIAMFDFHPVEPHDLRLVTGEEYFVLE-KKDAHWWKARNTYGQQGYIPSNYVTEK 259

  Fly   263 PLNSLEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISL--RYEGR----VYHYR 320
            .|::|.::.||...::|:.||.|| |....|.|:||.| |..|..::||  :|.|.    :.||.
Frog   260 KLDNLYQYEWYSRNMNRSKAEQLLKSEDKEGGFIVRNS-SQAGLYTVSLYTKYGGEGSTCIRHYH 323

  Fly   321 ISEDP-DGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNK--PTVFPLSPEPDEW 382
            |.|.. ..|.::.::..|||:.|::.:|.  |...||:|.|.||...:||  ||....|  .|:|
Frog   324 IKETQYPKKYYLAEKHVFNTIPEMIEYHK--HNAAGLVTRLRYPVCSKNKSAPTTAGFS--YDKW 384

  Fly   383 EICRTDIMMKHKLGGGQYGEVYEAVWK-RYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLV 446
            ||..:::....:||.|.:|.|....|: :|  .||:|.::|..|:.:||:|||.:|.::.|..||
Frog   385 EINPSELTFMKELGSGLFGVVRLGKWRAQY--KVAIKAIREGAMSEEDFIEEAKVMMKLTHLKLV 447

  Fly   447 QLIGVCTREPPFYIITEFMSHGNLLDFLRSA-GRETLDAVALLYMATQIASGMSYLESRNYIHRD 510
            ||.||||::.|.||:||||.||.||::||.. |:.:.|  .||.|...:...|||||..|:||||
Frog   448 QLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQFSPD--ILLSMCQDVCEAMSYLEQNNFIHRD 510

  Fly   511 LAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVL 575
            ||||||||.|..:|||:|||:.|.:.||.||:..|||||:||:.||...|::||:|||||:||||
Frog   511 LAARNCLVNDAGVVKVSDFGMTRYVLDDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVL 575

  Fly   576 LWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTF----KSI 636
            :||:.|.|..|:.:....:|...:.:|.|:.||......:|.:|..||......||.|    |.|
Frog   576 MWEVFTEGKMPFESYSNVEVVEMVTRGERLYRPKLATKIIYSVMVACWHEKPEGRPKFFDLMKQI 640

  Fly   637 HHALE 641
            ...||
Frog   641 GLILE 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	19/55 (35%)
		SH2_ABL	268..363	CDD:198189	34/102 (33%)
		PTKc_Abl	382..644	CDD:270645	120/266 (45%)
		Pkinase_Tyr	389..640	CDD:285015	115/256 (45%)
		FABD	1584..1723	CDD:197885
tec	XP_031751261.1	PH_Btk	27..168	CDD:269944
		SH3_Tec	204..259	CDD:212838	19/55 (35%)
		SH2_Tec_Itk	262..368	CDD:198259	37/108 (34%)
		PTKc_Tec_Rlk	386..645	CDD:270685	116/262 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920