Protein Alignment Abl and abl1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_002936228.2
• Gene: abl1 / 100490771
• XenbaseID: XB-GENE-6054675
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 1248
• Identity: 499/1248 - (39%)
• Similarity: 640/1248 - (51%)
• Gaps: 273/1248 - (21%)

  Fly   167 LGLQGSSLGGGHSSTTSVF------------------ESAHRWTSKENLLAPGPEEDDPQLFVAL 213
            |.|.|.....|.||::|.:                  ..|.||.||||||: ||.|:||.|||||
 Frog    33 LKLVGCKSKKGLSSSSSCYLEEALQRPTVSDIEPQGLSEAARWNSKENLLS-GPSENDPNLFVAL 96

  Fly   214 YDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPIS 278
            |||.|.|:|.||:.|||::|:|.||.:||||||.:.:|. |||||||:||:||.|||||||||:|
 Frog    97 YDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSPEKHSWYHGPVS 160

  Fly   279 RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAEL 343
            |||||||||||||||||||||||||||||||||||||||||||:...|||::|:.:::|||||||
 Frog   161 RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSDSRFNTLAEL 225

  Fly   344 VHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVW 408
            |||||...:  ||||.|.|||||:||||::.:||..|:|||.||||.|||||||||||||||.||
 Frog   226 VHHHSTVSD--GLITTLHYPAPKRNKPTIYGVSPNYDKWEIERTDITMKHKLGGGQYGEVYEGVW 288

  Fly   409 KRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDF 473
            |:|..||||||||||||.:::||:|||:|||:||||||||:||||||||||||||||::|||||:
 Frog   289 KKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEVKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 353

  Fly   474 LRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDD 538
            ||...|:.:.||.||:|||||:|.|.|||.:|:|||||||||||||:|.|||||||||:|||..|
 Frog   354 LRDCNRQEVTAVVLLHMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD 418

  Fly   539 TYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGY 603
            ||||||||||||||||||.|||||||.|||||||||||||||||||||||.|||:.||..|:|.|
 Frog   419 TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDY 483

  Fly   604 RMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSS- 667
            |||||.|||.:||:|||:||||...|||:|..||...|.|||||||::.|||:|.......:.|
 Frog   484 RMERPEGCPEKVYELMRECWQWSPLDRPSFAEIHQDFETMFQESSISDEVEKELGKKGLKVTVSN 548

  Fly   668 ---APS-------TSGVATGGGATTTTAASGCASSSSA-TASLSLTPQMVKKGLPGGQALTPNAH 721
               ||.       |..|.........||:...|..... ....:::|.:.:|....|..:.|:..
 Frog   549 LLQAPELPTKTRITRRVPESKDENAETASVRAAGELDVFEPESAVSPLLPRKERGAGDGVLPDDD 613

  Fly   722 HNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLL-----SSS 781
            ...|..::          |:...||...:.|             |.||.||||:|..     .|.
 Frog   614 RLLPKDKK----------TNLFFSTLIKRKK-------------KNAPTPPKRSSSFRDMEGHSE 655

  Fly   782 RDSTYREEDPANARCNFID--DLSTNGIHKLKTANYFSQT--LSRNFKTQIPTHHTHQIRTQQQQ 842
            |.||..|...||.. :.:|  .|||||. .|...:....|  ||..:|..          :....
 Frog   656 RRSTDGEGKEANGG-DLLDTFKLSTNGT-ALSNGSIQGSTGFLSSQWKKS----------STMTG 708

  Fly   843 QQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSCSSF-LYDILFRG--LARDINS------ 898
            :|.|..:::.|...|            :::....|:||... ..|..::.  |.|:|.|
 Frog   709 RQASPSEEETICSTS------------KRFLRSCSASCMPHGAKDTEWKSVTLPREITSSRCLLD 761

  Fly   899 --------------LTQRYDSETDP----------------AADP------DTDATGDSLEQSLS 927
                          |.::..:|:.|                ..||      |.|.:.:|...||:
 Frog   762 TPGSDSLKKAEKPALPRKRGNESKPEGTRGTVTPPPRLPKKCEDPNDEVFKDADPSPNSSPPSLT 826

  Fly   928 QVI---------AAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKR 983
            ..:         .||:..:...::..|......||.:.|          |...|....|.|..:
 Frog   827 PKLLRRKPAGPAGAPLQKEEASNIRLGSVNSDTGPSTKQ----------TSFAGKSEAELRLRR- 880

  Fly   984 SQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLE 1048
                        |.|            :.|.|...:.|:.||.    ...||        |.|:.
 Frog   881 ------------PKT------------SEPATKDKVKVLKVKP----SPPLP--------LSSIG 909

  Fly  1049 DSSEAAPALPATAPSLPPANGHATPPAARLNPK---------ASPIPPQQMIRSNSSGGVTMQNN 1104
            .|..|:..|...|.  ||:..|.|.|:   .||         .|..||.  :..:|...|.:.::
 Frog   910 SSPSASSNLGKAAK--PPSQSHDTSPS---EPKHKLTSQTDELSKTPPP--VPDSSKKPVLLSSS 967

  Fly  1105 AAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALA---NLEFPPPPLDLP 1166
            ......||       .|.|:      |||..|.|...:|..::...|.::   :|.      ...
 Frog   968 KPQVTGKL-------SGGMV------AGGDQSQPSAPSSSSSTAFVPLISTRVSLR------KTR 1013

  Fly  1167 PPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAPSVEEAS 1231
            .|||:...      |..:..|.|..:.|.|.:..|         :...:||:.|...|.::..
 Frog  1014 QPPEKHSS------PVTKETVMASTECLKAAIARN---------SEQMASHSTVLEAAKNLHA-- 1061

  Fly  1232 SRFGVSLRKREPSTDSCSSLGSPPEDLKEKL-----ITEIKAAGKD----TAPASHLANGSGIAV 1287
                           .|:|.....:.::.|.     |::::.:.:|    .|||   |.|.|.|.
 Frog  1062 ---------------FCTSYVDSIQQMRNKFAFREAISKLENSLRDLQICPAPA---AAGGGAAT 1108

  Fly  1288 VDPVSLLVTELAE 1300
            ....|.|:|.:.|
 Frog  1109 SQDFSKLLTSVKE 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	34/53 (64%)
		SH2_ABL	268..363	CDD:198189	74/94 (79%)
		PTKc_Abl	382..644	CDD:270645	200/261 (77%)
		FABD	1584..1723	CDD:197885
abl1	XP_002936228.2	SH3_Abl	92..145	CDD:212784	34/53 (64%)
		SH2_ABL	150..243	CDD:198189	74/94 (79%)
		PTKc_Abl	262..524	CDD:270645	200/261 (77%)
		F_actin_bind	1003..1128	CDD:471692	30/160 (19%)