DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and abl2

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	XP_002937405.1	Gene:	abl2 / 100487790	XenbaseID:	XB-GENE-6459814	Length:	1100	Species:	Xenopus tropicalis

Alignment Length:	1317	Identity:	511/1317 - (38%)
Similarity:	646/1317 - (49%)	Gaps:	307/1317 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GSRIKSSSSGVASGSGSGGGGGGSGSGLSQRSGGHKDA--RCNPTVGLNIFTEHNGTKHSSFRGH 121
            |....|:........|||.........::..|...::|  |.||..|.||||:|
Frog     9 GGEAPSAQQPHRGARGSGTKPSAHVGNIAATSSRRREATGRTNPETGFNIFTQH----------- 62

  Fly   122 PGKYHMNLEALLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFE 186
                    |||       |.|.||                                 .|......
Frog    63 --------EAL-------HRPYGS---------------------------------DSEPQALT 79

  Fly   187 SAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSG 251
            .|.||:||||||  |..|.||.||:|||||.|.|:|.||:.|||::|:|.||::|||||..|.:|
Frog    80 DAIRWSSKENLL--GATESDPNLFLALYDFVASGDNTLSITKGEKLRVLCYNQNGEWCEVLSKNG 142

  Fly   252 NVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 316
            . |||||||:||:||||||||||||:||:||||||||.||||||||||||||||.||||||||||
Frog   143 Q-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRV 206

  Fly   317 YHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE 381
            |||||:...||||:||.|::||||||||||||...:  ||:|.|.|||||.|||||:.:||..|:
Frog   207 YHYRINTASDGKVYVTAESRFNTLAELVHHHSTVAD--GLVTILHYPAPKCNKPTVYGVSPIHDK 269

  Fly   382 WEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLV 446
            ||:.||||.||||||||||||||..|||:|..||||||||||||.:::||:|||:|||:||||||
Frog   270 WEMERTDITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV 334

  Fly   447 QLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDL 511
            ||:||||.||||||:||:|.:|||||:||...||.:.||.||||||||:|.|.|||.:|:|||||
Frog   335 QLLGVCTLEPPFYIVTEYMHYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLERKNFIHRDL 399

  Fly   512 AARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLL 576
            ||||||||:|.:||||||||:|||..|||||||||||||||||||.||||.||.|||||||||||
Frog   400 AARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLL 464

  Fly   577 WEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 641
            ||||||||||||.|||:.||..|:||||||:|.||||:||:|||.||||:.:|||:|...|.|.|
Frog   465 WEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWQWNPSDRPSFSETHQAFE 529

  Fly   642 HMFQESSITEAVEKQLNANATSASSSA--------PSTSGVATGGGATTTTAASGCASSSSATAS 698
            .||.:|:|.|.|.::|...|.::||.:        ||.|.... ..|.......|...||..:.|
Frog   530 TMFHDSNINEEVAEELGRTAVTSSSVSYQCRLPMLPSKSRTLK-KKAENKENIEGTGDSSDNSTS 593

  Fly   699 LSLTPQMVKKGLP---GGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRT 760
             |.||.:: .|.|   |..||        |.:|:..:|.|..|  .||.:||:...||..   .:
Frog   594 -SSTPGLL-HGSPVASGSPAL--------PRKQRDKSPSSLLG--DTKETTFTRDRKGGF---FS 643

  Fly   761 TNKQGKQAPAPPKRTSLLSSSRDSTYRE-----EDPANARCNFIDDLSTNGIHKLKTANYFSQTL 820
            :..:.|.||.||||:|......:..::.     |.|:..:.:.:|..::.|.||.     :....
Frog   644 SFMKKKSAPQPPKRSSSFREMENQPHKRPELTGELPSFQQLDSLDSPASPGSHKC-----YGGGS 703

  Fly   821 SRNFK------------TQIPTHHTHQI--RTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQKQQQ 871
            .|:|.            |.|....|.::  :|...:..:|....::..|
Frog   704 QRSFPPEDVIGGIGGGWTGISGFFTPRLIKKTFGLRTGKSGSSGEEPKP---------------- 752

  Fly   872 YSIKKSSSCSSFL-----YDILFRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIA 931
              ..:|:|.||..     .|.|...|.|:.:....:.|..|..::.|:
Frog   753 --FPRSNSTSSMSPAVPEQDRLSMTLPRNCHRTKVQLDRTTSISSQPE----------------- 798

  Fly   932 APVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMG----NRGLETRQSKRSQLHSQAPG 992
                 :.||.|...|       ...|......:|...|..|    |.||.|...::|
Frog   799 -----ESQHDLQRSG-------LEIQPVRDRVKPKMLPRTGVSERNGGLRTGADEKS-------- 843

  Fly   993 PGPPSTQPHHG--NNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAP 1055
                |...|.|  .:...|:||...|..|           ....|:.|.....|..::.......
Frog   844 ----SPNKHTGGATSAFSTAAHNHKVPVL-----------ISPSPRNASTEVQLVGMDSLGHTFK 893

  Fly  1056 ALPATAPSLPPANGHATPPAARLNPKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRHRTTTE 1120
            .|....|  |..:....|...||.||.:|.||                   .:|..||
Frog   894 LLQEHVP--PTGSERDRPSHRRLKPKCAPPPP-------------------PNLRLLQ------- 930

  Fly  1121 GTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGG---------- 1175
                            .|:...:..|:...|.|.....|..|: |||||...:.|
Frog   931 ----------------PPQAEDTATAAPTLPCLERTTKPSRPM-LPPPPSVNQTGKLSNGAAGVG 978

  Fly  1176 ------PPPPP---PAPESAVQAIQQ-------HLHAQLPNNGNISNGNG-----TNNNDSSHND 1219
                  |..|.   ||.:.:.:|:.|       .|....||:..:..|:.     |...||....
Frog   979 RSVLRKPKQPTERVPAEKISKEALLQCAGLLSDALALPQPNSQLVDTGHQLLDYCTGYVDSISQT 1043

  Fly  1220 VSNIAPSVEEASSRFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAP------ASH 1278
            .:..|  ..||.||..|||::.:     .||.||               .|..|||      .:|
Frog  1044 RNKFA--FREAVSRLEVSLQELQ-----VSSAGS---------------GGASTAPPGANPVLNH 1086

  Fly  1279 LANGSGIAVVDPVSLLV 1295
            |     ::.|..:|.:|
Frog  1087 L-----LSCVQEISDVV 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	33/53 (62%)
		SH2_ABL	268..363	CDD:198189	73/94 (78%)
		PTKc_Abl	382..644	CDD:270645	196/261 (75%)
		Pkinase_Tyr	389..640	CDD:285015	189/250 (76%)
		FABD	1584..1723	CDD:197885
abl2	XP_002937405.1	SH3_Abl	100..153	CDD:212784	33/53 (62%)
		SH2_ABL	158..251	CDD:198189	73/94 (78%)
		PTKc_Abl	270..532	CDD:270645	196/261 (75%)
		F_actin_bind	984..1100	CDD:385063	34/142 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	772	1.000	Inparanoid score	I528
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm49301
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060