DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and btk

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_001123732.1	Gene:	btk / 100170477	XenbaseID:	XB-GENE-6451230	Length:	649	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	188/504 - (37%)
Similarity:	282/504 - (55%)	Gaps:	28/504 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 QQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQL----------FVALYD 215
            |.....:|.|......|...|    |.:.| .|::.|..|.|:|....|          .||:||
Frog   157 QTAKNAMGCQPLGNANGFIRT----ERSQR-RSRKPLPPPPPQESQKPLPPTPCLSLHKVVAMYD 216

  Fly   216 FQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPL-NSLEKHSWYHGPISR 279
            |.......|.|.|||:..:|.......|..|...:|..|::|.||||.. :.||.:.||...::|
Frog   217 FTPLNAQDLPLHKGEEYVLLEEGTGNPWLRARDKNGLEGYIPGNYVTEAQDPLEIYEWYSKNMTR 281

  Fly   280 NAAEYLL-SSGINGSFLVRESESSPGQRSISLRY-----EGRVYHYRISEDPDGKVFVTQEAKFN 338
            :.||.|| :....|.|:||:| |..|:.::|: |     ||.:.||.:.|.|..:.::.::..::
Frog   282 SQAEKLLRAEDKEGGFIVRDS-SKAGKYTVSV-YAKSSGEGIIRHYVVCEAPGNQYYLAEKHLYS 344

  Fly   339 TLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEV 403
            ::.||:.:|.  |...|||:.|.||.....|............|||...|:....:||.||:|.|
Frog   345 SIPELITYHQ--HNAAGLISRLKYPVCSLRKTAPSTAGLGYGSWEIDPKDLTFLKELGNGQFGVV 407

  Fly   404 YEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHG 468
            ....| |..:.||:|.:||.:|:..:|:|||..|.::.|.|||||.||||::.|.:|||||:|:|
Frog   408 KYGKW-RGQHDVAIKMIKEGSMSEDEFIEEAKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNG 471

  Fly   469 NLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLAR 533
            .||::|:.. |..:....||.|.:.:.:.|:||||:.|:|||||||||||..:.:|||:||||:|
Frog   472 CLLNYLKDL-RGRVSQGDLLSMCSDVCAAMTYLESKQYLHRDLAARNCLVAADGIVKVSDFGLSR 535

  Fly   534 LMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHK 598
            .:.||.||:..|:|||::|::||.|.|.:||:|||||:||||:||:.|.|..||......::..:
Frog   536 YVLDDEYTSSLGSKFPVRWSSPEVLLYCRFSSKSDVWSFGVLMWEVFTLGRMPYDRFTNNEIVEQ 600

  Fly   599 LDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQES 647
            :.:|.|:.||......||.:|..||...|.|||||:.:|:.:..:.::|
Frog   601 ITRGVRLYRPQNATDRVYSIMVSCWAEKADDRPTFRILHNTILEVLEDS 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	20/63 (32%)
		SH2_ABL	268..363	CDD:198189	31/100 (31%)
		PTKc_Abl	382..644	CDD:270645	119/261 (46%)
		Pkinase_Tyr	389..640	CDD:285015	115/250 (46%)
		FABD	1584..1723	CDD:197885
btk	NP_001123732.1	PH_Btk	8..167	CDD:269944	2/9 (22%)
		SH3_BTK	209..264	CDD:212839	19/54 (35%)
		SH2_Tec_Btk	267..370	CDD:198260	34/106 (32%)
		PKc_like	388..638	CDD:419665	116/251 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920