Protein Alignment Abl and mst1ra

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_005166175.1
• Gene: mst1ra / 100002448
• ZFINID: ZDB-GENE-071218-2
• Length: 1356
• Species: Danio rerio
• Alignment Length: 744
• Identity: 191/744 - (25%)
• Similarity: 302/744 - (40%)
• Gaps: 167/744 - (22%)

  Fly    10 GAHSGGGGSGAPVSCIGLSSSPVASVS---PHCISSSSGVSSA------PLGGGSTLRGS----- 60
            |.|...||| ..:| :|..:.||.|||   ...:..|.||...      .:..|||:..:
Zfish   677 GKHLDAGGS-RTIS-LGDRNCPVESVSSDGTSIVCRSEGVKDTLEVDVKVVIDGSTISSTKTFSY 739

  Fly    61 RIKSSSSGVASGSGSGGGG-----GGSGSGLSQR----SGGHKDARCNPTVGLNIFTEHNGTKHS 116
            |:....:||....|...|.     |.:...:||.    .||:||.         :.|..:|
Zfish   740 RVNPEVTGVNPNCGFRRGSKIIITGQNLDSVSQAVIKYKGGYKDP---------VETVCSG---- 791

  Fly   117 SFRGHPGKYHMNLEALLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSST 181
              :|:|    ..:|.:   .|:.....|..:..|             .|...||..:.....:..
Zfish   792 --QGNP----TQMECM---SPVCEESTGILSVDL-------------DGAKDLQSQTFTCHANGE 834

  Fly   182 TSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEA 246
            ...||:..|...    |:||.:|      |:|:      ..:|:|..|....|::.|  |..|.|
Zfish   835 PIPFETEDRVLE----LSPGQDE------VSLH------HKKLALVSGCMEIIMTVN--GVDCNA 881

  Fly   247 H-SDSGNVGWVPSNYVTP--------LNSLEKHSWYHGPISRNA-------AEYLLSSGINGSF- 294
            . .|:.....:|.|...|        |.:.|:|. ....:.:|:       ...|.:.|:..:.
Zfish   882 KVLDNEITCRIPKNLTIPRQGAPVKVLVNREEHD-IGMVVMKNSNLIVGVVLGILAAVGVGAAIV 945

  Fly   295 --------------LVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVH 345
                          ||....|....|:.:..|:         ..|||. :..:..:...|:....
Zfish   946 YVAMAQERKKKKAALVEVRLSMHSNRTTAENYD---------RSPDGD-YRRETVRPAGLSVSPF 1000

  Fly   346 H------HSVPHEG--HGLITPLLYPAPKQNKPTVFPLSPE-----------PDEWEICRTDIMM 391
            |      .|:|:.|  .....||:     :.:.::..|.|:           ||:       |.:
Zfish  1001 HGSGTTFTSLPYAGSMDSAAAPLM-----RRQVSMSALRPDLLEEVKNVLISPDK-------IKI 1053

  Fly   392 KHK--LGGGQYGEVYEAVWKRYGNT---VAVKTLKE--DTMALKDFLEEAAIMKEMKHPNLVQLI 449
            :|:  :|.|.:|.||........|.   .|||:|..  |...::.||.|...||...|.:::.|:
Zfish  1054 QHEQIIGKGHFGTVYHGYLTDSDNKETHCAVKSLNRITDLEEVEQFLREGLFMKAFHHSHVLSLL 1118

  Fly   450 GVCTREPPF-YIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAA 513
            |:....... .:|..:|.||:|..|:||..|.. ....|:....|:|.||.||.::.::||||||
Zfish  1119 GIVLPSDGLPLVILPYMKHGDLRHFIRSPERSP-TVKDLIGFGLQVAKGMEYLANKKFVHRDLAA 1182

  Fly   514 RNCLVGDNKLVKVADFGLARLMRDDTYTA---HAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVL 575
            |||::.::..|||||||:||.:.|..|.:   ...||.|:||.|.|.|...||:||||||::|||
Zfish  1183 RNCMLDESFTVKVADFGMARDVYDKEYYSIQDSKKAKLPVKWMALESLQTQKFTTKSDVWSYGVL 1247

  Fly   576 LWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL 640
            :||:.|.|.||||.:|..|:...|.:|.|:.:|..|...::.::.|||..:...||.|.::..|:
Zfish  1248 MWELLTRGASPYPDVDPYDITPYLMQGRRLPQPQYCFDSLWSVLMQCWHPEPEKRPGFTTLVQAV 1312

  Fly   641 EHMFQESSITEAVEKQLNANATSASSSAP 669
            :.:  .||:..  |..:|...|..:...|
Zfish  1313 QDI--HSSLDG--EHYINLQITYVNLDQP 1337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	13/54 (24%)
		SH2_ABL	268..363	CDD:198189	20/124 (16%)
		PTKc_Abl	382..644	CDD:270645	98/272 (36%)
		FABD	1584..1723	CDD:197885
mst1ra	XP_005166175.1	Sema_MET_like	41..504	CDD:200509
		PSI	507..549	CDD:396154
		IPT	550..654	CDD:472823
		IPT_plexin_repeat2	655..740	CDD:238584	18/64 (28%)
		IPT	742..828	CDD:214657	22/120 (18%)
		PTKc_Met_Ron	1057..1318	CDD:270649	96/263 (37%)