DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and abl1

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	XP_005172104.1	Gene:	abl1 / 100000720	ZFINID:	ZDB-GENE-100812-9	Length:	1081	Species:	Danio rerio

Alignment Length:	1030	Identity:	456/1030 - (44%)
Similarity:	573/1030 - (55%)	Gaps:	175/1030 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 QSRP----LPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFES------- 187
            |.||    ||.|.|        |...|..:|              |..|.:..:|.||
Zfish    12 QRRPSLPALPFIKA--------AGRRETPRH--------------GAPHCNVFTVHESRPDFDPP 54

  Fly   188 ----AHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHS 248
                |.||.||||||: ||.|:||.||||||||.|.|:|.||:.|||::|:|.||.:||||||.:
Zfish    55 GLSEAARWNSKENLLS-GPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT 118

  Fly   249 DSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYE 313
            .:|. |||||||:||:||||||||||||:||||||||||||||||||||||||||||||||||||
Zfish   119 KNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYE 182

  Fly   314 GRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPE 378
            ||||||||:...|||::|:.|::||||||||||||...:  ||||.|.|||||:||||::.:||.
Zfish   183 GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVSD--GLITTLHYPAPKRNKPTIYGVSPN 245

  Fly   379 PDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHP 443
            .|:||:.||||.|||||||||||||||.|||:|..||||||||||||.:::||:|||:|||:|||
Zfish   246 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP 310

  Fly   444 NLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIH 508
            |||||:||||||||||||||||:||||||:||...|:.::||.||||||||:|.|.|||.:|:||
Zfish   311 NLVQLLGVCTREPPFYIITEFMTHGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH 375

  Fly   509 RDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFG 573
            |||||||||||:|.|||||||||:|||..|||||||||||||||||||.|||||||.||||||||
Zfish   376 RDLAARNCLVGENNLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFG 440

  Fly   574 VLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHH 638
            |||||||||||||||.|||:.||..|:|.|||:||.|||.:||:|||.||:|:..:||:|...|.
Zfish   441 VLLWEIATYGMSPYPGIDLSQVYELLEKDYRMDRPEGCPEKVYELMRACWRWNPAERPSFAETHQ 505

  Fly   639 ALEHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLT- 702
            |.|.|||||||::.|||:|.......:......:........|......|....|...|...:|
Zfish   506 AFETMFQESSISDEVEKELGKKGKKLTLGPIQQAPELPTKTRTLRRPTDGRDGDSPDAAEAEVTG 570

  Fly   703 PQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQ 767
            |.|:.:.|     |..|.:.:|..|       |:......:::.||           ...|:.:.
Zfish   571 PPMMPRPL-----LDSNLNEDDRLQ-------SKDNKDKFRMNPFS-----------YIKKKKRT 612

  Fly   768 APAPPKRTSLL----------------------SSSRDSTYREEDPANARCNFIDDLSTNGIHKL 810
            |||||||:|..                      .||.:......||    |..:...||..|...
Zfish   613 APAPPKRSSSFGKMDGHLDRRGLGTDCREDFSNGSSTNDALNSIDP----CKLVGSNSTTTIGVT 673

  Fly   811 KTANYFSQTLSRNFKTQIPTHHTH---------QIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQ 866
            ..|..:...|       .|:|...         ::.|....::.|:...::.:..|.........
Zfish   674 NGAPVYPGQL-------FPSHPRKKGTTSGGGGKLATTPPPEEDSMSNSKRFLRSSSSSSMPPGS 731

  Fly   867 QKQQQYSIKKSSSCSSFLYDI-LFRG---LARDINSLTQRYDSETDPAADP--DTDATGDSLEQS 925
            .:.:..|:.......|..:|. .|||   |.|  .|...|..:.|.|...|  ..|.:.:..:.|
Zfish   732 DRFEWKSVTLPRDIQSTHFDSNTFRGKPALPR--KSCMPRGGTLTPPPRLPKKSEDVSDEVFKDS 794

  Fly   926 LSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFK-------RPTGTPVMGNRGLETRQSKR 983
            .|...::|:|...:           :|.|...:.|...       :|...|.:|:.|    :.:|
Zfish   795 ESSPGSSPLTLTPK-----------LGRRPQTESSKTSALQTEVLKPNVLPPLGDEG----RPRR 844

  Fly   984 SQLHSQAPG-------------PGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLP 1035
            .:|.|:.||             |.||........:| .||..|....:.|
Zfish   845 LKLSSEIPGQREREKGKFAKPKPAPPPPPVSSAKSG-KTSRSPTFEVSSD--------------- 893

  Fly  1036 KGARIGAYLDSLED-----SSEAAPALPATAPSLPPANGHATPPAARLNPKASPI 1085
              .::.:.|||.:.     |.|:|..||.....:.|:...||.|...:.  |||:
Zfish   894 --TKVKSSLDSADQGKASLSQESAKKLPKNGSKVNPSKAGATAPLPGMG--ASPV 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	34/53 (64%)
		SH2_ABL	268..363	CDD:198189	75/94 (80%)
		PTKc_Abl	382..644	CDD:270645	198/261 (76%)
		Pkinase_Tyr	389..640	CDD:285015	191/250 (76%)
		FABD	1584..1723	CDD:197885
abl1	XP_005172104.1	SH3_Abl	79..132	CDD:212784	34/53 (64%)
		SH2_ABL	137..230	CDD:198189	75/94 (80%)
		PTKc_Abl	249..511	CDD:270645	198/261 (76%)
		Pkinase_Tyr	256..507	CDD:285015	191/250 (76%)
		FABD	958..1081	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I632
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	790	1.000	Inparanoid score	I494
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm24997
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17274
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.990