DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment onecut and ONECUT2

DIOPT Version :9

Sequence 1:	NP_001259065.1	Gene:	onecut / 45816	FlyBaseID:	FBgn0028996	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	NP_004843.2	Gene:	ONECUT2 / 9480	HGNCID:	8139	Length:	504	Species:	Homo sapiens

Alignment Length:	690	Identity:	208/690 - (30%)
Similarity:	258/690 - (37%)	Gaps:	358/690 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 SSP---GFSQTSYATLTPIQPLPPISTMSEKFAY------------------SGHISGGDSGDTD 370
            |||   |.|.| |.||||:||||||||:|:||.:                  ||::||..:...|
Human   137 SSPPGMGMSNT-YTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHQRLSGNVSGSFTLMRD 200

  Fly   371 VNGDGAGGGVVEVGEVTNQSSEATG-TVSISSGNATSSVCSNNDCSSFSALSMPIGSGHLGLGVL 434
            ..      |:..:..:.:...|..| :.|:|...||                 |:|:   |||.|
Human   201 ER------GLPAMNNLYSPYKEMPGMSQSLSPLAAT-----------------PLGN---GLGGL 239

  Fly   435 SGVQSPFSSYEKLSSMISPPPNNYLVS--CDLHSSVSGRVINSSHLQLSHNGNKKESGTHEHTHR 497
            ...|....:|       .||.::.::|  .|.|
Human   240 HNAQQSLPNY-------GPPGHDKMLSPNFDAH-------------------------------- 265

  Fly   498 PADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKFIYSDHISEGENGPD 562
                      :|..::||:                                   .|:|.|
Human   266 ----------HTAMLTRGE-----------------------------------QHLSRG----- 280

  Fly   563 VNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGSLSRHLAPNAPICPADWK 627
                                                   |..|||  ::..||
Human   281 ---------------------------------------LGTPPA--AMMSHL------------ 292

  Fly   628 ADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSPGHREQYFLDKSQEPSSVV 692
                                                     |....|||        :|....|:
Human   293 -----------------------------------------NGLHHPGH--------TQSHGPVL 308

  Fly   693 ADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGTVSSGGAVSNRIANSSDM 757
            |..               .::.||:                        |||    :::|.|..:
Human   309 APS---------------RERPPSS------------------------SSG----SQVATSGQL 330

  Fly   758 EEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYKWL 822
            ||||||::||||:||||||||||||||||||||||||||||||||||||||||||||||||:|||
Human   331 EEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWL 395

  Fly   823 QEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNESD 887
            ||||||||||||:||
Human   396 QEPEFQRMSALRLAA-------------------------------------------------- 410

  Fly   888 SSPASTPVTSVLVGSVVSCRRKE-EPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQV 951
                              |:||| ||..::....||.||||||||||||.|||||.||||||||:
Human   411 ------------------CKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQI 457

  Fly   952 TIARQLGLEPTTVGNFFMNARRRSMDKWRDD----DSKST 987
            ||::|||||.|||.||||||||||::||:||    .|.||
Human   458 TISQQLGLELTTVSNFFMNARRRSLEKWQDDLSTGGSSST 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_001259065.1	CUT	756..830	CDD:280527	67/73 (92%)
onecut	NP_001259065.1	HOX	920..975	CDD:197696	45/54 (83%)
ONECUT2	NP_004843.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..95
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..189		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..332		23/242 (10%)
		CUT	331..403	CDD:396794	67/71 (94%)
		HOX	426..481	CDD:197696	45/54 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..504		6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144941
Domainoid	1	1.000	148	1.000	Domainoid score	I4472
eggNOG	1	0.900	-	-		E1_KOG2252
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001166
OrthoInspector	1	1.000	-	-		otm41948
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3544
SonicParanoid	1	1.000	-	-		X793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.870