DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment onecut and cux1a

DIOPT Version :9

Sequence 1:	NP_001259065.1	Gene:	onecut / 45816	FlyBaseID:	FBgn0028996	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	XP_005172775.1	Gene:	cux1a / 797445	ZFINID:	ZDB-GENE-030131-5868	Length:	1495	Species:	Danio rerio

Alignment Length:	1190	Identity:	240/1190 - (20%)
Similarity:	398/1190 - (33%)	Gaps:	412/1190 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSLNDIIDHQTFSQELVEDASEFITVGHHSERPSQSSQQPNSGQDLTMSMQDIISCPVKHRTCSA 66
            :.|.|..|::...:||....|    |.|:|.....|:|..:...::.::.:|       |...|.
Zfish   356 EKLQDQSDYEEIKRELCTLKS----VEHNSSDHHSSAQDSSKPLEMLLTGKD-------HSQLSE 409

  Fly    67 SGSGSASGSDSVVMVIDALGQGNRQSAYQIVPQQLQQRNMPL----------PFGLLERDRQHMQ 121
            |.....:.||    ...|:|:..:::..: .||:|....:|.          |..|:.......:
Zfish   410 SALKRLANSD----FTGAVGRKLKETTVE-NPQRLPATPVPTTLQGSPPPPSPQLLMRTGTATSE 469

  Fly   122 HGREVN-TSPVDFVSSDINLDGLTVD-ADVSQT-----DHSQETAVKQEQKLLIVQSKS-QDQSH 178
            .....| |.|  |..:.|..|..|.. |.|..|     ......::.|.|.:..:.:|: ||.|.
Zfish   470 SAASANGTHP--FSPTGIGPDFFTPGMASVGATFPPLAGKMALNSLLQRQLMQTIYTKALQDPSP 532

  Fly   179 RRIRM----LVDVSSVNSGLGVHVDDMDEIS--------SDGVGCDDEGVTLSHQHLLEQ-EEQF 230
            ..:..    ....:|::|.|........|::        |:|.|...||..:....:..| :||.
Zfish   533 SSVLFGPPHYATTNSLSSPLPPQSAGSPEVNGMAPSPSQSEGAGSTSEGEEMDTAEIARQVKEQL 597

  Fly   231 GLTSHHPHLQPHTQIIHGLHQR-STHSEMGLDNGH-GEVLS-------VIVHSQD---------S 277
                          |.|.:.|| ..|..:||..|. .|:|:       :.:..::         |
Zfish   598 --------------IKHNIGQRVFGHYVLGLSQGSVSEILARPKPWSKLTIRGKEPFHKMKHFLS 648

  Fly   278 DKEDC----------EENDD--------------GDAEGDLE-----------NEDDDERDSRSR 307
            |:::.          .||..              |.:||...           ....||......
Zfish   649 DEQNILALRSIQGRQRENPGQNLNRVFQDVPKRRGGSEGSTRPGNITTRIRTPETGSDEAIKSIL 713

  Fly   308 EQLLSHSSYQTLTSVNDRLSSPGFSQTS------YATLTPIQ----PLPPISTMSEKFAYSGHIS 362
            ||.......|....|.:|....|:.:.|      ||....::    .|.|: .|:::|..|...|
Zfish   714 EQAKRELQVQKADGVGERHRRSGYHRGSGSYFQIYAHSLRLEESNIDLKPM-RMTKQFESSQPPS 777

  Fly   363 GGDSGDTDVNGDGAGGGVVEVG--EVTNQSSEATGTVSISSGNATSSVCSNNDCSSFSALSMPIG 425
            ...:.|.::.      .::|..  |:..|.......:..||...|.             ||: :|
Zfish   778 SSSNSDENIR------SILEQARREMEAQQVALEPVLKASSMGPTD-------------LSL-LG 822

  Fly   426 SGHLGLGVLSGVQSPFSS--YEKLSSMISPPPNNYLVSCDLHSSVSGRVINSSHLQLSHNGNKKE 488
            |..||        ||.|:  |..::..:..|.::.|:  |.|                |.|.|||
Zfish   823 SKLLG--------SPLSTLPYTPITQSLKKPSSSPLL--DFH----------------HGGVKKE 861

  Fly   489 SGTHEHTHRPADVNG-----GKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKF 548
            .|  |.......::|     |:.|.:|                      :.||      :.||.:
Zfish   862 MG--EVAVSDVGLDGVVPKLGRLSESG----------------------LGGG------SWREHW 896

  Fly   549 IYSDHISE--GENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGSL 611
             :|..:||  |.:.|.|:.     ..||:.:.:..:|
Zfish   897 -WSTGLSERRGSSQPSVSE-----DAHSQEDSKEKLP---------------------------- 927

  Fly   612 SRHLAPNAPICPA-------DWKADDWKHSNAGVVSL----------TADMP---VVVSL----T 652
              .|...||:.||       ||.:.:..:|.:..:||          ::.:|   .::||    .
Zfish   928 --RLGSTAPVAPASSLDYWKDWPSSESPYSQSSELSLQMPSGSETPQSSPLPSSSPLLSLPKVAK 990

  Fly   653 PTPPPLR-----------------------------------DDSVSGIKQNE----RSSPGH-- 676
            |..|||.                                   .:.|.|:.|..    .|.|.|
Zfish   991 PVVPPLTPEQYEYYMYQEVDTVDLTQQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKHWS 1055

  Fly   677 -----------REQYFLD------------KSQEPSSVVADQCSPGINGTPQS------VCVIHQ 712
                       |.|.:|:            ::||.:...:..|||    .|:|      ..|..|
Zfish  1056 KLTQKGREPFIRMQLWLNGELGQALMPMPGQTQEITPKTSASCSP----APESPLSSAEESVKSQ 1116

  Fly   713 QSPSALGNGFQSSSQQAKVSSCASPKGTV-------SSGGAVSNRIANSSDMEEINTKDLAQRIS 770
            |......:..|..|:.::     |..||.       .:|.::...:|.|:   |::|..:.:::.
Zfish  1117 QEEQMCRSSVQEPSEASE-----SQPGTPLPLPLPGQAGLSIQEMVAMSA---ELDTYVITKKVK 1173

  Fly   771 AELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLK-SGRETFRRMYKWLQEP-------EF 827
            ..|...::.|.:|.:.:|..:||::||||..||||.||. .|||.|.||..||.:|       :.
Zfish  1174 EVLTDNNLGQRLFGESILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLSDPRNVEKLMDM 1238

  Fly   828 QRM---SALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNESDSS 889
            :||   :.::...:.|.:...|.||:|....|     .|..|..|.....|..:|
Zfish  1239 KRMEKKAYMKRRHSSIGESHSLESGLSAADLT-----QGASPQHLSQQQPPQQMQ---------- 1288

  Fly   890 PASTPVTSVLVGSVVSCRRKEEPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQVTIA 954
                                  || :|.||.||||:|....::..|:..:::...||.:....:|
Zfish  1289 ----------------------PQ-QQQPQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELA 1330

  Fly   955 RQLGLEPTTVGNFFMNARRR 974
            .||.|:.:||.|:|.|.|.|
Zfish  1331 SQLNLKTSTVINWFHNYRSR 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_001259065.1	CUT	756..830	CDD:280527	27/81 (33%)
onecut	NP_001259065.1	HOX	920..975	CDD:197696	19/55 (35%)
cux1a	XP_005172775.1	Tropomyosin	127..371	CDD:278679	3/14 (21%)
		RILP-like	<290..>359	CDD:304877	0/2 (0%)
		Med3	325..>574	CDD:288447	46/235 (20%)
		CUT	580..653	CDD:280527	17/86 (20%)
		CUT	1005..1073	CDD:280527	8/67 (12%)
		CUT	1159..1236	CDD:280527	28/79 (35%)
		Homeobox	1299..1352	CDD:278475	17/52 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2252
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810