DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment onecut and onecut3a

DIOPT Version :9

Sequence 1:	NP_001259065.1	Gene:	onecut / 45816	FlyBaseID:	FBgn0028996	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	XP_694209.1	Gene:	onecut3a / 565854	ZFINID:	ZDB-GENE-050208-744	Length:	451	Species:	Danio rerio

Alignment Length:	795	Identity:	228/795 - (28%)
Similarity:	296/795 - (37%)	Gaps:	358/795 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 EISSDGVGCDDEGVTLSHQHLLEQEEQFGLTSHHPHLQPHTQIIHGLHQRSTHSEMGLDNGHGEV 267
            |::.:.:| :..||  ||.|      |.|...:.||.:          |.:||  ..|.:.||.
Zfish     2 ELTMENIG-NLHGV--SHSH------QTGDLMNSPHAR----------QSATH--RNLVSSHGR- 44

  Fly   268 LSVIVHSQDSDKEDCEENDDGDAEGDLENEDDDERDSRSREQLLSHSSYQTLTSVNDRLSSPGFS 332
             |.:|.|..|..         |..|:...:..           ||...:..:|...|  ||...|
Zfish    45 -SAMVSSMASIL---------DGAGEYRTDHS-----------LSGPLHPAMTMSCD--SSMSLS 86

  Fly   333 QTSYATLTPIQ-PLPPISTMSEKFAYSGHISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGT 396
            .| |.||||:| .|||||.:|:||.:..|                           ..:......
Zfish    87 ST-YTTLTPLQHHLPPISNVSDKFHHHPH---------------------------PHAHHHPAH 123

  Fly   397 VSISSGNATSSVCSNNDCSSFSALSMPIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVS 461
            ..:::||.:.|.....|....:::|...  ||.... |||:..|.|           |.:|.|.|
Zfish   124 QRLAAGNVSGSFTLMRDDRGLASMSNLY--GHYSKD-LSGMGPPLS-----------PLSNGLGS 174

  Fly   462 CDLHSSVSGRVINSSHLQLSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEK 526
              ||:|   :...|::...:|.||.|...           :||..|:...:.||:
Zfish   175 --LHNS---QQTLSAYGPSAHLGNDKMIS-----------SGGFESHAAMLGRGE---------- 213

  Fly   527 FSFSDHISGGDSGDEDANREKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEAR 591
                                     :|::.|..|
Zfish   214 -------------------------EHLARGLGG------------------------------- 222

  Fly   592 FHISSERRTRLNVPPARGSLSRHLAPNAPICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPP 656
                                                      ..||::|
Zfish   223 ------------------------------------------HGAGIMS---------------- 229

  Fly   657 PLRDDSVSGIKQNERSSPGHREQYFLDKSQEPSSVVADQCSPGINGTPQSVCVIHQQSPSALGNG 721
                 |::||..:...|..|        ||...||::::
Zfish   230 -----SLNGINHHHHHSHSH--------SQANGSVLSER-------------------------- 255

  Fly   722 FQSSSQQAKVSSCASPKGTVSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQR 786
                .:||         |....||       .|..:||||||::||||:||||||||||||||||
Zfish   256 ----DRQA---------GAGGQGG-------GSGQVEEINTKEVAQRITAELKRYSIPQAIFAQR 300

  Fly   787 VLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMS 851
            :|||||||||||||||||||||||||||||||:|||||||||||||||:||
Zfish   301 ILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAA-------------- 351

  Fly   852 LGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKEEPQ-IE 915
                                                                  |:|||:.| .|
Zfish   352 ------------------------------------------------------CKRKEQEQHKE 362

  Fly   916 QMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRSMDKWR 980
            :...|||.||||||||||||.|||||.||||||||:||::|||||.:||.|||||||||.:|:|.
Zfish   363 RNMAPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQLTISQQLGLELSTVSNFFMNARRRCVDRWH 427

  Fly   981 DDDSKSTMHVAHSRQ 995
            ::....  |||...|
Zfish   428 EEHHHG--HVASPGQ 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_001259065.1	CUT	756..830	CDD:280527	66/73 (90%)
onecut	NP_001259065.1	HOX	920..975	CDD:197696	45/54 (83%)
onecut3a	XP_694209.1	CUT	272..344	CDD:280527	66/71 (93%)
onecut3a	XP_694209.1	HOX	367..422	CDD:197696	45/54 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578183
Domainoid	1	1.000	148	1.000	Domainoid score	I4409
eggNOG	1	0.900	-	-		E1_KOG2252
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3721
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001166
OrthoInspector	1	1.000	-	-		otm24351
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14057
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.890