Protein Alignment onecut and onecut1

DIOPT Version :10

• Sequence 1: NP_524842.2
• Gene: onecut / 45816
• FlyBaseID: FBgn0028996
• Length: 1081
• Species: Drosophila melanogaster
• Sequence 2: NP_956867.1
• Gene: onecut1 / 393545
• ZFINID: ZDB-GENE-040426-1469
• Length: 461
• Species: Danio rerio
• Alignment Length: 775
• Identity: 227/775 - (29%)
• Similarity: 281/775 - (36%)
• Gaps: 359/775 - (46%)

  Fly   246 IHGLHQRSTHSEMGL---DNGHGEVLSVIVHSQDSDKEDCEENDDGDA----EGDLENEDDDERD 303
            :||:.....||...|   |:.|        |..............|.|    .||..:....|..
Zfish    13 LHGVSHEPVHSAADLMTGDSAH--------HRSHRSSLSAHARSMGMASILDSGDYHHHRPPEHP 69

  Fly   304 SRSREQLLSHSSYQTLTSVNDRLS-----SPGFSQTS-YATLTPIQPLPPISTMSEKFAYSGH-- 360
            ..:             |.::..:|     .||.|.:| |.||||:||||||||:|:||.:..|
Zfish    70 GLA-------------THLHPAMSMACEAPPGMSMSSTYTTLTPLQPLPPISTVSDKFPHHHHHH 121

  Fly   361 ----------ISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNNDCS 415
                      |.|..||...:..|..|     :..:.|..|.....|: |.|            .
Zfish   122 HHHHHHPHQRIPGNVSGSFTLMRDDRG-----LAPMNNLYSPYHKDVA-SMG------------Q 168

  Fly   416 SFSALSMPIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVSCDLHSSVSGRVINSSHLQL 480
            |.|.||   |||      |||:.         :|....||..:          .|..:.:..: |
Zfish   169 SLSPLS---GSG------LSGIH---------NSQQGLPPYAH----------PGATMPAEKM-L 204

  Fly   481 SHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANR 545
            :.||.:        .|.||
Zfish   205 TPNGFE--------AHHPA---------------------------------------------- 215

  Fly   546 EKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGS 610
                                   .|..|.|:    ||..          ||.....:||
Zfish   216 -----------------------MLARHGEQ----HMSA----------SSASMVPINV------ 237

  Fly   611 LSRHLAPNAPICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSPG 675
              .|..|:|             |.||                                     .|
Zfish   238 --IHHHPHA-------------HLNA-------------------------------------QG 250

  Fly   676 HREQYFLDKSQEPSSVVADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGT 740
            |.:.....:.|..|||      ||                |.|.||
Zfish   251 HGQVLGSTREQNHSSV------PG----------------SQLNNG------------------- 274

  Fly   741 VSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPW 805
                       ::|..|||:|||::||||:.||||||||||||||||||||||||||||||||||
Zfish   275 -----------SSSGQMEEVNTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPW 328

  Fly   806 SKLKSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLD 870
            |||||||||||||:|||||||||||||||:|                |..|
Zfish   329 SKLKSGRETFRRMWKWLQEPEFQRMSALRLA----------------GERT-------------- 363

  Fly   871 PHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKEEP--QIEQMPQPKKPRLVFTDLQRR 933
                                             ::|:|||:.  :.|:....|||||||||:|||
Zfish   364 ---------------------------------IACKRKEQEHGKGERGNISKKPRLVFTDVQRR 395

  Fly   934 TLQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRSMDKWRDDDSKSTMHVAHS 993
            ||.|||||.||||||:|:||::|||||..||.||||||||||:|||.||.|.::.:.:.|
Zfish   396 TLHAIFKENKRPSKELQITISQQLGLELATVSNFFMNARRRSLDKWLDDGSSNSANSSSS 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_524842.2	CUT	756..830	CDD:460543	66/73 (90%)
		HOX	920..975	CDD:197696	43/54 (80%)
onecut1	NP_956867.1	CUT	279..353	CDD:460543	66/73 (90%)
		HOX	382..437	CDD:197696	43/54 (80%)