Protein Alignment onecut and Onecut2

DIOPT Version :10

• Sequence 1: NP_524842.2
• Gene: onecut / 45816
• FlyBaseID: FBgn0028996
• Length: 1081
• Species: Drosophila melanogaster
• Sequence 2: NP_001387562.1
• Gene: Onecut2 / 307376
• RGDID: 1564677
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 692
• Identity: 209/692 - (30%)
• Similarity: 257/692 - (37%)
• Gaps: 360/692 - (52%)

  Fly   327 SSP---GFSQTSYATLTPIQPLPPISTMSEKFAY--------------------SGHISGGDSGD 368
            |||   |.|.| |.||||:||||||||:|:||.:                    ||::||..:..
  Rat   136 SSPPGMGMSNT-YTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHHHQRLSGNVSGSFTLM 199

  Fly   369 TDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNNDCSSFSAL-SMPIGSGHLGLG 432
            .|..|         :..:.|..|......|:|              .|.|.| :.|:|:   |||
  Rat   200 RDERG---------LPSMNNLYSPYKEMPSMS--------------QSLSPLAATPLGN---GLG 238

  Fly   433 VLSGVQSPFSSYEKLSSMISPPPNNYLVS--CDLHSSVSGRVINSSHLQLSHNGNKKESGTHEHT 495
            .|...|....:|       .||.::.::|  .|.|
  Rat   239 GLHNAQQSLPNY-------GPPGHDKMLSPNFDAH------------------------------ 266

  Fly   496 HRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKFIYSDHISEGENG 560
                        :|..::||:                                   .|:|.|
  Rat   267 ------------HTAMLTRGE-----------------------------------QHLSRG--- 281

  Fly   561 PDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGSLSRHLAPNAPICPAD 625
                                                     |..|||  ::..||
  Rat   282 -----------------------------------------LGTPPA--AMMSHL---------- 293

  Fly   626 WKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSPGHREQYFLDKSQEPSS 690
                                                       |....|||        :|....
  Rat   294 -------------------------------------------NGLHHPGH--------TQSHGP 307

  Fly   691 VVADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGTVSSGGAVSNRIANSS 755
            |:|..               .::.||:                        |||    :::|.|.
  Rat   308 VLAPS---------------RERPPSS------------------------SSG----SQVATSG 329

  Fly   756 DMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYK 820
            .:||||||::||||:||||||||||||||||||||||||||||||||||||||||||||||||:|
  Rat   330 QLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWK 394

  Fly   821 WLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNE 885
            ||||||||||||||:||
  Rat   395 WLQEPEFQRMSALRLAA------------------------------------------------ 411

  Fly   886 SDSSPASTPVTSVLVGSVVSCRRKE-EPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEM 949
                                |:||| ||..::....||.||||||||||||.|||||.|||||||
  Rat   412 --------------------CKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEM 456

  Fly   950 QVTIARQLGLEPTTVGNFFMNARRRSMDKWRDD----DSKST 987
            |:||::|||||.|||.||||||||||::||:||    .|.||
  Rat   457 QITISQQLGLELTTVSNFFMNARRRSLEKWQDDLGTGGSSST 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_524842.2	CUT	756..830	CDD:460543	67/73 (92%)
		HOX	920..975	CDD:197696	45/54 (83%)
Onecut2	NP_001387562.1	CUT	332..404	CDD:460543	67/71 (94%)
		HOX	427..482	CDD:197696	45/54 (83%)