DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment onecut and Cux2

DIOPT Version :9

Sequence 1:	NP_001259065.1	Gene:	onecut / 45816	FlyBaseID:	FBgn0028996	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	XP_038945174.1	Gene:	Cux2 / 288665	RGDID:	1305967	Length:	1522	Species:	Rattus norvegicus

Alignment Length:	912	Identity:	194/912 - (21%)
Similarity:	320/912 - (35%)	Gaps:	252/912 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 DAEGDLENE-DDDERDSRSREQLLSHSSYQTL----------TSVNDRLSSPG------------ 330
            |..|..|.: |..|...:.:||||.|:..|.:          .||::.|:.|.
  Rat   567 DGAGPEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEP 631

  Fly   331 --------FSQTSYATLTPIQP----------LPPISTMSEKFAYSGHISGGDSGDTDVNGDGAG 377
                    ..:.:...|..||.          :||..:::.:..           ..:...|.|.
  Rat   632 FIKMKQFLSDEQNVLALRTIQVRQRGPTAATFVPPPGSITPRIR-----------TPETGSDDAI 685

  Fly   378 GGVVEVG--EVTNQ----SSEATGTVSISSGNATSSVC----------SNNDCSSFSALSMPIGS 426
            ..::|..  |:.:|    |..:..:|||.:|.|:||..          :..:..:.....:.:.|
  Rat   686 KSILEQAKKEIESQKGGESKNSPASVSIPNGTASSSTSEDAIKNILEQARREMQAQQQALLEMES 750

  Fly   427 GHLGLGVLSGVQSPFSSYEKLSSMISPPP----NNYLVSC------DLHSSVSG----------- 470
            |..|..|      |.|..|:      |.|    .|..::|      ...||.||
  Rat   751 GPRGRSV------PPSPPER------PSPATMSQNGALACVKQEDGGCSSSSSGSAQAPLAVLSP 803

  Fly   471 -----RVINSSHLQLSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSFS 530
                 |:|.....::.      ::|..:| |..:|        .|.:||..:          |.|
  Rat   804 AAFVQRIIRKVKSEIG------DAGYFDH-HWASD--------RGLLSRPYA----------SVS 843

  Fly   531 DHISGGDSGDEDANREKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHIS 595
            ..:|...|.....|...:...|   |....|:..:.|..    .|.|.    |...||:|...:|
  Rat   844 PSLSSSSSYSGQPNGRAWPRGD---EATIAPEDEAATGM----GEDEA----PRVGELKAEAGVS 897

  Fly   596 SERRTRLNVPPARGSLSRHLAPNA-PICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLR 659
            .....||...||  .:.|.|.|.. |:.|..::.  :.:.....:.||..:...::.......:.
  Rat   898 EVGGGRLPYYPA--YVPRTLKPTVPPLTPEQYEL--YMYREVDTLELTRQVKEKLAKNGICQRIF 958

  Fly   660 DDSVSGIKQNERS-----------------SPGHREQYFLD--------KSQEPSSVVADQCSP- 698
            .:.|.|:.|...|                 .|..|.|.:|.        .:|:||   |.|.||
  Rat   959 GEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQGQAPNQQPS---ASQASPT 1020

  Fly   699 ---GINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCAS------PKGTVSSGGAVSNRIANS 754
               .....|.|.....:.|...||...:||.:..:....||      |..:..:.|.:...:|.|
  Rat  1021 EPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSTLGGKPLSSSQTTGGIQEMVAMS 1085

  Fly   755 SDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLK-SGRETFRRM 818
               .|::|..:.:|:...|...::.|.:|.:.:|..:||::||||..||||.||. .|||.|.||
  Rat  1086 ---PELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRM 1147

  Fly   819 YKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLT 883
            ..||.:|  ..:..|| ...::.::|.|..            ..|.|.|..|.       ::|..
  Rat  1148 RLWLSDP--HNVEKLR-DVKKLEKKAYLKR------------RYGLISTGSDS-------ESPAA 1190

  Fly   884 NESDSSPASTPVTSVLVGSVVSCRRKEEPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKE 948
            :....||..                  :||...:.|.||||:|....::..|:..::....||::
  Rat  1191 HSECPSPCL------------------QPQELSLMQAKKPRVVLAPAEKEALRKAYQLEPYPSQQ 1237

  Fly   949 MQVTIARQLGLEPTTVGNFFMNAR---RRSM--DKWRDD------DSKSTMHVAHSRQQQDEQQK 1002
            ....::.||.|:..||.|:|.|.|   ||.|  :..:||      ...|.:...|:......|..
  Rat  1238 TIELLSFQLNLKTNTVVNWFHNYRSRMRREMLVEGTQDDPDFDPSGGSSVLPSGHTHTDPTPQSP 1302

  Fly  1003 DNAHTHSQSQIQDQNHSQNQAIHNSMSQDPYSNLHTTAMS-PLGAFDEDADMDLELESHDFDLVD 1066
            |       |:|:|    |...:.:...|:|.|.:|..|.. .:....::..::::.:|...|:.|
  Rat  1303 D-------SEIED----QKPPMKSLELQEPESPVHQAAPDRAVVKIKQEEGLEVDGDSQPQDIGD 1356

  Fly  1067 PD 1068
            ||
  Rat  1357 PD 1358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_001259065.1	CUT	756..830	CDD:280527	28/74 (38%)
onecut	NP_001259065.1	HOX	920..975	CDD:197696	18/57 (32%)
Cux2	XP_038945174.1	SMC_prok_B	<185..>388	CDD:274008
		CUT	572..648	CDD:396794	13/75 (17%)
		CUT	931..1004	CDD:396794	10/72 (14%)
		CUT	1084..1160	CDD:396794	29/80 (36%)
		Homeobox	1212..1266	CDD:395001	15/53 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2252
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810