DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment onecut and Onecut2

DIOPT Version :9

Sequence 1:	NP_001259065.1	Gene:	onecut / 45816	FlyBaseID:	FBgn0028996	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	NP_919244.2	Gene:	Onecut2 / 225631	MGIID:	1891408	Length:	505	Species:	Mus musculus

Alignment Length:	692	Identity:	209/692 - (30%)
Similarity:	257/692 - (37%)	Gaps:	360/692 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 SSP---GFSQTSYATLTPIQPLPPISTMSEKFAY--------------------SGHISGGDSGD 368
            |||   |.|.| |.||||:||||||||:|:||.:                    ||::||..:..
Mouse   136 SSPPGMGMSNT-YTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHHHQRLSGNVSGSFTLM 199

  Fly   369 TDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNNDCSSFSAL-SMPIGSGHLGLG 432
            .|..|         :..:.|..|......|:|              .|.|.| :.|:|:   |||
Mouse   200 RDERG---------LPSMNNLYSPYKEMPSMS--------------QSLSPLAATPLGN---GLG 238

  Fly   433 VLSGVQSPFSSYEKLSSMISPPPNNYLVS--CDLHSSVSGRVINSSHLQLSHNGNKKESGTHEHT 495
            .|...|....:|       .||.::.::|  .|.|
Mouse   239 GLHNAQQSLPNY-------GPPGHDKMLSPNFDAH------------------------------ 266

  Fly   496 HRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKFIYSDHISEGENG 560
                        :|..::||:                                   .|:|.|
Mouse   267 ------------HTAMLTRGE-----------------------------------QHLSRG--- 281

  Fly   561 PDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGSLSRHLAPNAPICPAD 625
                                                     |..|||  ::..||
Mouse   282 -----------------------------------------LGTPPA--AMMSHL---------- 293

  Fly   626 WKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSPGHREQYFLDKSQEPSS 690
                                                       |....|||        :|....
Mouse   294 -------------------------------------------NGLHHPGH--------TQSHGP 307

  Fly   691 VVADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGTVSSGGAVSNRIANSS 755
            |:|..               .::.||:                        |||    :::|.|.
Mouse   308 VLAPS---------------RERPPSS------------------------SSG----SQVATSG 329

  Fly   756 DMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYK 820
            .:||||||::||||:||||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse   330 QLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWK 394

  Fly   821 WLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNE 885
            ||||||||||||||:||
Mouse   395 WLQEPEFQRMSALRLAA------------------------------------------------ 411

  Fly   886 SDSSPASTPVTSVLVGSVVSCRRKE-EPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEM 949
                                |:||| ||..::....||.||||||||||||.|||||.|||||||
Mouse   412 --------------------CKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEM 456

  Fly   950 QVTIARQLGLEPTTVGNFFMNARRRSMDKWRDD----DSKST 987
            |:||::|||||.|||.||||||||||::||:||    .|.||
Mouse   457 QITISQQLGLELTTVSNFFMNARRRSLEKWQDDLGTGGSSST 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_001259065.1	CUT	756..830	CDD:280527	67/73 (92%)
onecut	NP_001259065.1	HOX	920..975	CDD:197696	45/54 (83%)
Onecut2	NP_919244.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..94
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..190		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..333		23/242 (10%)
		CUT	332..404	CDD:308148	67/71 (94%)
		HOX	427..482	CDD:197696	45/54 (83%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835045
Domainoid	1	1.000	148	1.000	Domainoid score	I4442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001166
OrthoInspector	1	1.000	-	-		otm43997
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3544
SonicParanoid	1	1.000	-	-		X793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970