DRSC/TRiP Functional Genomics Resources

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Protein Alignment onecut and CUX1

DIOPT Version :9

Sequence 1:NP_001259065.1 Gene:onecut / 45816 FlyBaseID:FBgn0028996 Length:1081 Species:Drosophila melanogaster
Sequence 2:XP_005250207.1 Gene:CUX1 / 1523 HGNCID:2557 Length:1604 Species:Homo sapiens


Alignment Length:1267 Identity:226/1267 - (17%)
Similarity:399/1267 - (31%) Gaps:442/1267 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 QELVEDASEFITVGHHSERPSQSSQQPNSG--QDLTMSMQDIISCPVKHRT-----CSASGSGSA 72
            |:|..|.:|       .||..|.:|...:.  ::....:|.:.:...|.||     .:.....:.
Human   266 QKLQNDFAE-------KERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT 323

  Fly    73 SGSDSVVMVIDALGQGNR-----QSAYQIVPQQLQQRNMPLPFGLLERDRQHMQHGREVNTS--- 129
            :.:|.:.|::..|.:.|:     |...:.:.:||...|..|......:....::...||.|.   
Human   324 AKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSL 388

  Fly   130 PVDFVSSDINLDGLTVD-----ADVSQTDHSQETAVKQEQKLLIVQSKSQDQSHRRIRMLVDVSS 189
            .|:..:.:..:..|..|     |.:::...:..:.:.|.::.|..::.:..|...:::...|...
Human   389 EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEE 453

  Fly   190 VNSGLGVHVDDMDEISSDGVGCDDEGVTLSHQHLLEQEEQFGLTSHHPHLQPHTQIIHGLHQRST 254
            |...|.: :..|:...|:|.|..|....|   .:|..|:...|.|.:..|:.....:.|..:|..
Human   454 VKKELNI-LKSMEFAPSEGAGTQDAAKPL---EVLLLEKNRSLQSENAALRISNSDLSGSARRKG 514

  Fly   255 HSE--------------MGLDNGHGEVLSVIVHSQDSDKEDCEENDDGDAEGD------------ 293
            ..:              ..|....||        |.|:.....:........|            
Human   515 KDQPESRRPGSLPAPPPSQLPRNPGE--------QASNTNGTHQFSPAGLSQDFFSSSLASPSLP 571

  Fly   294 LENEDDDERDSRSREQLLS---HSSYQTLTSVNDRLSSPGFSQTSYATLTPIQPLPPISTMSEKF 355
            |.:......:|..:.||:.   ..:.|...|.:...|:..:|..|.::.:|:|..|.::.|:...
Human   572 LASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSP 636

  Fly   356 AYS---GHISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNNDCSSF 417
            :.|   |.:|.|:..||              .|:..|..|              .:..:|     
Human   637 SQSESAGSVSEGEEMDT--------------AEIARQVKE--------------QLIKHN----- 668

  Fly   418 SALSMPIGS---GHLGLGVLSGVQS-------PFSS--------YEKLSSMISPPPNNYLVSCDL 464
                  ||.   ||..||:..|..|       |::.        :.|:...:|...|...:    
Human   669 ------IGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILAL---- 723

  Fly   465 HSSVSGRVINSSHLQLSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSF 529
             .|:.||       |..:.|........|                        |....||.:.:.
Human   724 -RSIQGR-------QRENPGQSLNRLFQE------------------------VPKRRNGSEGNI 756

  Fly   530 SDHISGGDSGDEDANREKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAE-LEARFH 593
            :..|...::|.::|.:.                       :...::||:::....||: ..|...
Human   757 TTRIRASETGSDEAIKS-----------------------ILEQAKRELQVQKTEPAQPSSASGS 798

  Fly   594 ISSERRTRLNVPPARGSLSRHLAPNAPICPADWKADDWKHSNAGVVS----LTADMPVVVSLTPT 654
            .:|:...|..:..||..:.   |..|.:.|| .|......|:..:::    .|:.||.|.|..|.
Human   799 GNSDDAIRSILQQARREME---AQQAALDPA-LKQAPLSQSDITILTPKLLSTSPMPTVSSYPPL 859

  Fly   655 PPPLRDDSVS------------GIKQNERSSPGHREQYFLDKSQEPSSVVADQCSPGINGTPQSV 707
            ...|:..|.:            .:|:..:.:||...|...|.:|.....|.::.  |.:|..:. 
Human   860 AISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEV--GRSGAWKD- 921

  Fly   708 CVIHQQSPSALGNGFQSSSQQAKVSSC--ASPKGTVSSGGAVSNR-------------------- 750
               |..|.........:||::||....  ...||:..|||....|                    
Human   922 ---HWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPS 983

  Fly   751 ----IANSSDM---------------------------------------------EEINTKDLA 766
                .:.||::                                             :|::|.:|.
Human   984 AESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELT 1048

  Fly   767 QRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKL-KSGRETFRRMYKWL-------- 822
            :::..:|.:..|.|.||.::||..|||::||:|..||||||| :.|||.|.||..||        
Human  1049 RQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGV 1113

  Fly   823 -------QEPEFQRMSALR-------MAAAQIPQ---------RAPLSSGMSLGSAT-------- 856
                   |.|....:::|:       :::...|:         .:|:||..|:.|.|        
Human  1114 LPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCP 1178

  Fly   857 ----------------GPSGSTGTIP------------------TDLDPHGGPTMIQNPLTNE-- 885
                            ..|.|..|.|                  .:||.:|....::..||:.  
Human  1179 PIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNL 1243

  Fly   886 ----------------------------------------------------------------- 885
                                                                             
Human  1244 GQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAY 1308

  Fly   886 --------SDSSPASTPVTSVLVGSVVSCRRKEEPQIEQMPQPKKPRLVFTDLQRRTLQAIFKET 942
                    |||.|...|    .||:..|.....:||    .|.||||:|....::..|:..:::.
Human  1309 MKRRHSSVSDSQPCEPP----SVGTEYSQGASPQPQ----HQLKKPRVVLAPEEKEALKRAYQQK 1365

  Fly   943 KRPSKEMQVTIARQLGLEPTTVGNFFMNARRR 974
            ..||.:....:|.||.|:.:||.|:|.|.|.|
Human  1366 PYPSPKTIEDLATQLNLKTSTVINWFHNYRSR 1397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
onecutNP_001259065.1 CUT 756..830 CDD:280527 33/134 (25%)
HOX 920..975 CDD:197696 19/55 (35%)
CUX1XP_005250207.1 Smc <106..464 CDD:224117 34/205 (17%)
CUT 647..720 CDD:367059 18/111 (16%)
PHA03247 846..>1032 CDD:223021 31/191 (16%)
CUT 1038..1106 CDD:367059 30/67 (45%)
CUT 1221..1294 CDD:367059 5/72 (7%)
Homeobox 1346..1400 CDD:365835 17/52 (33%)
PRK12678 1404..>1493 CDD:237171
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2252
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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