Protein Alignment onecut and Cux2

DIOPT Version :9

• Sequence 1: NP_001259065.1
• Gene: onecut / 45816
• FlyBaseID: FBgn0028996
• Length: 1081
• Species: Drosophila melanogaster
• Sequence 2: XP_011246473.2
• Gene: Cux2 / 13048
• MGIID: 107321
• Length: 1595
• Species: Mus musculus
• Alignment Length: 1385
• Identity: 268/1385 - (19%)
• Similarity: 437/1385 - (31%)
• Gaps: 471/1385 - (34%)

  Fly     3 SLNDIIDHQTF--SQELVEDASEFITVGHHSERPSQSSQQPNSGQDLTMSMQDIISCPVKHRTCS 65
            :|:|.:...:|  |.:.::|.  .|......|.|  |:::.|.|           :||..|  ..
Mouse   207 TLDDRLQRPSFDPSGQRLQDV--HIAWKRCPEPP--SAREQNEG-----------TCPTGH--TP 254

  Fly    66 ASGSGSASGSDSVVMVIDALGQGN---RQSAYQIVPQQLQQRNMPLPFG---------------- 111
            |:|:......|:  :|.|.|.|.|   ||...|.|...|..|     .|
Mouse   255 ANGNHLPGPEDT--LVTDTLLQKNEAERQKGLQEVHITLAAR-----LGEAEEKIKVLHSALKAT 312

  Fly   112 ---LLERDRQHMQHGREVNTSPVDFVSSDINLDGLTVDADVSQTDHSQETAVKQEQKLLIVQSKS 173
               |||..|::.:.... ....|..:.:::.......:|...:.:..:|........:.:.....
Mouse   313 QTELLELRRKYDEEAAS-KADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSP 376

  Fly   174 QDQSHRRI----------------------RMLVDVSSVNSGLGVHVDDMDEISSDGVGCDDEGV 216
            |..|..::                      |:|.|...:...|    .:::|:|::.:...:..:
Mouse   377 QGPSGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSL----QELEEVSANQIADLERQL 437

  Fly   217 TLSHQHLLEQEEQFGLTSHHPHLQPHTQIIHGLHQRSTHSEMGLDNGHGEVLSVIVHSQD----- 276
            ....:.:.:.:|:....:.:..::....|:..:...|  |...|.....:....::.::|
Mouse   438 AAKSEAIEKLQEKLEAQADYEEIKTELSILRAMKLAS--STCSLPQTLAKPDDPLLVAKDVFFPT 500

  Fly   277 ------------SDKEDCEENDDGDAEGDLENE---DDDERDSRSREQLLSHSSYQTLTSVNDRL 326
                        |.:||..|:|  ..:|.|..|   ..........|..||.|..|.|  :...|
Mouse   501 QKFLLEKPALLASPEEDPSEDD--SIKGSLGTEPPYPPQLPPPPGPEDPLSPSPAQPL--LGPSL 561

  Fly   327 SSPG---FSQTSYATLTPIQPLPPISTMSEKFAYSGHISG-----GDSGD------TDVNG---- 373
            ...|   ||.:.:.:|.|.:.|...|.:|:      |:.|     |::|:      |...|
Mouse   562 GPDGPRTFSLSPFPSLAPGERLAGDSLLSK------HMMGPAAFKGETGNLLAFPPTFYGGAKPP 620

  Fly   374 -------------------DGAG--GGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNNDCSSF 417
                               ||||  ...::..|:..|..|
Mouse   621 SAPAASVPCPEPTGAPEAVDGAGPEEEQLDTAEIAFQVKE------------------------- 660

  Fly   418 SALSMPIGS---GHLGLGVLSGVQS------------------PFSSYEKLSSMISPPPN----- 456
            ..|...||.   ||..||:..|..|                  ||.   |:...:|...|
Mouse   661 QLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFI---KMKQFLSDEQNVLALR 722

  Fly   457 ---------NYLVSCDLHSSVSGRV----------INSSHLQLSHNGNKKESGTHEHTHRPADV- 501
                     .......|..|::.|:          |.|...|.......::.|  |..:.||.|
Mouse   723 TIQVRQRGPTAATFVPLPGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGG--ESKNSPASVS 785

  Fly   502 --NGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKFIYSDHISEGENGP--- 561
              ||...|.|..    |::.|.:                  |.|.||.......:.|.|:||
Mouse   786 IPNGTASSSTSE----DAIKNIL------------------EQARREMQAQQQALLEMESGPRGR 828

  Fly   562 ---------------------------DVNSGTNWLQMHSEREVRLHMPV--PAELEARF----- 592
                                       |...|:.     |...|:..:.|  ||....|.
Mouse   829 SVPPSPPERPSPATASQNGALTCVKQEDGGGGSG-----SSSTVQAPLAVLSPAAFVQRIIRKVK 888

  Fly   593 -----------HISSER----RTRLNVPPARGSLSRHLA-PN---------APICPADWKA--DD 630
                       |.:|:|    |...:|.|:..|.|.:.. ||         |.|.|.|..|  :|
Mouse   889 SEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSYSGQPNGRAWPRGDEATIAPEDEAAMGED 953

  Fly   631 WKHSNAGVVSLTADMP-------------VVVSLTPTPPPLR----------------------- 659
             :....|.:...|..|             |..:|.||.|||.
Mouse   954 -EAPRVGELKAEAGAPEVGGGRLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKE 1017

  Fly   660 ------------DDSVSGIKQNERS-----------------SPGHREQYFLD----------KS 685
                        .:.|.|:.|...|                 .|..|.|.:|.          .:
Mouse  1018 KLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQGQGQAPT 1082

  Fly   686 QEPSSVVADQCSP----GINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCAS------PKGT 740
            |:||   |.|.||    .....|.|.....:.|...||...:||.:..:....||      |..:
Mouse  1083 QQPS---ASQASPTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSSLGGKPFSS 1144

  Fly   741 VSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPW 805
            ..:.|.:...:|.|   .|::|..:.:|:...|...::.|.:|.:.:|..:||::||||..||||
Mouse  1145 SQAAGGIQEMVAMS---PELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPW 1206

  Fly   806 SKLK-SGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDL 869
            .||. .|||.|.||..||.:|  ..:..|| ...::.::|.|..            ..|.|.|..
Mouse  1207 HKLSLKGREPFVRMQLWLSDP--HNVEKLR-DMKKLEKKAYLKR------------RYGLIGTGS 1256

  Fly   870 DPHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKEEPQIEQMPQPKKPRLVFTDLQRRT 934
            |.       ::|..:....||..                  :||...:.|.||||:|....::..
Mouse  1257 DS-------ESPAAHSECPSPCL------------------QPQELSLMQAKKPRVVLAPAEKEA 1296

  Fly   935 LQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNAR---RRSM--DKWRDD------DSKSTM 988
            |:..::....||::....::.||.|:..||.|:|.|.|   ||.|  :..:||      ...:.:
Mouse  1297 LRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDDPDFDPSGGPNVL 1361

  Fly   989 HVAHSRQQQDEQQKDNAHTHSQSQIQDQNHSQNQAIHNSMSQDPYSNLHTTAMS-PLGAFDEDAD 1052
            ...|:.::...|..|       |:.:|    |...:.:...|:|...|...|.. .|....::..
Mouse  1362 TPGHTHREPTPQSPD-------SETED----QKPPMKSLELQEPEGPLQRAAPDRALVKIKQEEG 1415

  Fly  1053 MDLELESHDFDLVDPDEHGD 1072
            ::::.:|...|:.|||...|
Mouse  1416 LEVDGDSQPQDVGDPDRGQD 1435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_001259065.1	CUT	756..830	CDD:280527	28/74 (38%)
		HOX	920..975	CDD:197696	18/57 (32%)
Cux2	XP_011246473.2	Smc	<279..473	CDD:224117	24/203 (12%)
		CUT	645..718	CDD:367059	16/100 (16%)
		CUT	1002..1075	CDD:367059	8/72 (11%)
		CUT	1157..1230	CDD:367059	29/77 (38%)
		Homeobox	1285..1339	CDD:365835	15/53 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2252
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810