Protein Alignment onecut and onecut2

DIOPT Version :10

• Sequence 1: NP_524842.2
• Gene: onecut / 45816
• FlyBaseID: FBgn0028996
• Length: 1081
• Species: Drosophila melanogaster
• Sequence 2: XP_002934489.3
• Gene: onecut2 / 100485320
• XenbaseID: XB-GENE-485246
• Length: 463
• Species: Xenopus tropicalis
• Alignment Length: 779
• Identity: 221/779 - (28%)
• Similarity: 282/779 - (36%)
• Gaps: 372/779 - (47%)

  Fly   217 TLSHQHLLEQEEQFGLTSHHPHLQPHTQIIHGLHQRSTHSEMGLDNGHGEVLSVIVHSQDSDKED 281
            :|:..|.....||..::||.||           |.|..|.::...:..    |.:|.|..|..
 Frog    28 SLASLHGGTSHEQDLISSHSPH-----------HHRRLHQDLTPPSSR----SAMVSSMASIL-- 75

  Fly   282 CEENDDGDAEGDLENEDDDERDSRSREQLLSHSSYQTLTSVNDRLSSPGFSQTS-YATLTPIQPL 345
                   |..|:...|             ||...:..|:...|. |.||...:| |.||||:|||
 Frog    76 -------DGAGEYRPE-------------LSIPLHHALSMPCDS-SPPGMGMSSTYTTLTPLQPL 119

  Fly   346 PPISTMSEKFAYSGH-----------ISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGTVSI 399
            |||||:||||.:..|           :|...||...:..|..|     :..:.|..|...   .:
 Frog   120 PPISTVSEKFHHPHHHPHHHHHHHQRLSANVSGSFTLMRDERG-----IPAMNNLYSPYK---DM 176

  Fly   400 SSGNATSSVCSNNDCSSFSALSMPIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVSCDL 464
            ..|.:.|.:...           |:|:   |||.:...|....:|       .||.::.::|.:.
 Frog   177 GMGQSLSPLAGT-----------PLGN---GLGSIHNTQQSLHNY-------GPPVHDKMLSPNF 220

  Fly   465 HSSVSGRVINSSHLQLSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSF 529
            .                                         ::|..::|||
 Frog   221 D-----------------------------------------AHTAMLARGD------------- 231

  Fly   530 SDHISGGDSGDEDANREKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHI 594
                                  .|:|.|
 Frog   232 ----------------------QHLSRG------------------------------------- 237

  Fly   595 SSERRTRLNVPPARGSLSRHLAPNAPICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLR 659
                   |..||:  ::..||
 Frog   238 -------LGTPPS--AMMSHL-------------------------------------------- 249

  Fly   660 DDSVSGIKQNERSSPGHREQYFLDKSQEPSSVVADQCSPGINGTPQSVCVIHQQSPSALGNGFQS 724
                ||:  :..|.|||        :|....|:|..               ..:.||:.|:...|
 Frog   250 ----SGM--HHPSHPGH--------AQTHGPVLASS---------------RDRPPSSSGSQMNS 285

  Fly   725 SSQQAKVSSCASPKGTVSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLC 789
            |.|                             :||||||::||||:|||||||||||||||||||
 Frog   286 SGQ-----------------------------LEEINTKEVAQRITAELKRYSIPQAIFAQRVLC 321

  Fly   790 RSQGTLSDLLRNPKPWSKLKSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGS 854
            |||||||||||||||||||||||||||||:|||||||||||||||:||
 Frog   322 RSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAA----------------- 369

  Fly   855 ATGPSGSTGTIPTDLDPHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKE-EPQIEQMP 918
                                                               |:||| ||..::..
 Frog   370 ---------------------------------------------------CKRKEQEPNKDRNN 383

  Fly   919 QPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRSMDKWRDD 982
            ..||.||||||||||||.|||||.||||||||:||::|||||..||.||||||||||::||:||
 Frog   384 TQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELNTVSNFFMNARRRSLEKWQDD 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_524842.2	CUT	756..830	CDD:460543	67/73 (92%)
		HOX	920..975	CDD:197696	44/54 (81%)
onecut2	XP_002934489.3	CUT	290..362	CDD:460543	67/71 (94%)
		HOX	385..440	CDD:197696	44/54 (81%)