DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment onecut and cux2

DIOPT Version :9

Sequence 1:	NP_001259065.1	Gene:	onecut / 45816	FlyBaseID:	FBgn0028996	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	NP_001128286.2	Gene:	cux2 / 100038096	XenbaseID:	XB-GENE-487236	Length:	1498	Species:	Xenopus tropicalis

Alignment Length:	1295	Identity:	252/1295 - (19%)
Similarity:	433/1295 - (33%)	Gaps:	435/1295 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SASGSDSVVMVIDALGQGNRQSAYQIVPQQLQQRNMPLPFGLLERDRQHMQHGREVNTSPVDFVS 135
            :||.:|.|.|::..|.:.||::                     |..::.::..||..:|    |:
Frog   235 TASKTDEVGMIMTNLEKANRRA---------------------EAAQREVESLREQLSS----VN 274

  Fly   136 SDINLDGLTVDADVSQTD--------HSQETAVKQEQKLLIVQSKSQDQSHRRIRMLVDVSSVNS 192
            :.|.|...:..|.....|        |.:.....:::::|              |:|.|:....:
Frog   275 NSIRLTCCSPQASSGDKDSFSLCSGSHLEAALAVKDREIL--------------RLLKDIQHFQN 325

  Fly   193 GLGVHVDDMDEISSDGVGCDDEGVTLSHQHLLEQEEQFGLTSHHPHLQPHTQIIHGLHQRSTHSE 257
            .    :.:::|.|::.:...::.:.:..:.:.:.||:....|.:..::....|:..:...|.:..
Frog   326 S----IQELEESSANQIAELEQQLVIKTEAIEKLEEKLRRQSDYEEIKTELSILKAMKSASANCT 386

  Fly   258 MGLDNGHGEVLSVIVHSQ----------------DSDKEDCEENDDGDAEGDLENEDDDERDSRS 306
            :..:|...|. |:::..:                .|::||             ::|||..:.|..
Frog   387 ISQENSTPED-SLLIEKETFFPSQTYVLEKQRILPSNEED-------------QSEDDSMKQSLG 437

  Fly   307 REQLLSHS---SYQTLTSVNDRLSSPGFSQTSYATLTPIQPLPPISTMSEKFAYSGHISGGDSGD 368
            .|:..|.|   |:||    .|.:.:|..||                .:.|..|:
Frog   438 AERPYSSSPRTSFQT----RDGVVTPSSSQ----------------CLQEAAAH----------- 471

  Fly   369 TDVNGDGAGGGVVEVGEVT------NQSSEATGTVSISSGNATSSVCSNNDC-----SSFSALSM 422
                          ||:.|      |.|.:..|.|.:.....:..:.|.|:.     |||.::..
Frog   472 --------------VGQRTISSTFPNTSEQLPGEVPLKKHMVSPVLKSENNTMLSFPSSFYSVKS 522

  Fly   423 PIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVSCD---------LHSSVSGRVINSSHL 478
            .|...||. ..::...||.|...:.||. |.....::.:.:         |..::..||.....|
Frog   523 TILPNHLS-ATVNNDSSPLSDQSEASSS-SSADEEHIDTSEIAFQVKEQLLKHNIGQRVFGHYVL 585

  Fly   479 QLSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVN---------GEKFSFSDHIS 534
            .|| .|:..|........|...|.|.:    ..|.....:.::.|         .::.|.:..|.
Frog   586 GLS-QGSVSEILARPKPWRKLTVKGKE----PFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIR 645

  Fly   535 GGDSGDEDA------NREKFIYSDH--ISEGENGPDVNSGTNWLQMHSE-----------REVRL 580
            ..::|.:||      ..:|.|.|..  .::|.|.|  .|.::.:...||           ||::.
Frog   646 TPETGSDDAIKNILEQAKKEIQSQKGGDTKGSNAP--LSSSSSITSSSEDAIKSILEQARREMQA 708

  Fly   581 HMPVPAELEARFHISSERRTRLNVPPARGSL---SRHLAPNAPICPADWKADDWKHSNAGVVSLT 642
            ...|..|:|     |......:|.|||...:   |.|.|.:..|          |......::..
Frog   709 QQQVLLEIE-----SGNGHRSMNTPPAERPILTPSTHNAAHIHI----------KQEEGTFITSA 758

  Fly   643 ADMPVVVS-LTPTPPPLRDDSVSGIKQNERSSPGHREQYF----------LDK---SQEPS-SVV 692
            |.:...:| |:|..      .|..|.:..:|..|....||          |.:   |..|| |..
Frog   759 ASIQTPLSVLSPAA------FVQNIIRKVKSEIGDAGSYFDQHWATERNLLSRPLMSVSPSLSSS 817

  Fly   693 ADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGTVSSGGAVSNRIA----- 752
            :...|..|||.|.......:.:||.  ....::.:..||....:..|.:....  .||::
Frog   818 SSSYSGMINGRPWRRADTCETAPSE--EEITTAEEAHKVVEVKTEAGNLDQQN--MNRLSYYPAY 878

  Fly   753 --------------NSSDM---EEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLR 800
                          ...:|   .|::|.||.:::..:|.:..|.|.||.::||..|||::||:|.
Frog   879 VPRNLKPTVPPLTPEQYEMYMYREVDTLDLTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLS 943

  Fly   801 NPKPWSKL-KSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGT 864
            .||||||| :.|||.|.||..||.:          .....|.|:..||.|....|.|..|.|...
Frog   944 RPKPWSKLTQKGREPFIRMQLWLTD----------QLGQGITQQPALSQGTLSPSETHSSPSPSP 998

  Fly   865 IPTD-----------------LDPHGGP--------------TMIQN--PLTNESDSSPASTPVT 896
            .|.:                 |.|...|              |.||.  .::.|.|:...:..|.
Frog   999 SPPEQEKSPLLILSLESTKENLQPESRPASSLSGRSFPNHQATGIQEMVAMSPELDTYSITKKVK 1063

  Fly   897 SVLV------------------GSVVSCRRKEEP-----------------------QIEQM--- 917
            .||.                  |||.....:.:|                       .||::
Frog  1064 EVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLSDPHNIERLRDM 1128

  Fly   918 -----------------------------------PQP--------KKPRLVFTDLQRRTLQAIF 939
                                               |||        ||||:|....::.||:..:
Frog  1129 KKMEKKAYLKRRYGLISGGSDSESSNTKTECASPSPQPQEYSHLQMKKPRVVLGLEEKETLKKAY 1193

  Fly   940 KETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRS-----MDKWRDDD------------SKST 987
            :....||::....::.||.|:..||.|:|.|.|.|.     ::..:|:|            |..|
Frog  1194 QLEPYPSQQTIEQLSFQLNLKTNTVINWFHNYRSRMRREILIEGQQDNDTDQEPSSCDSFTSVCT 1258

  Fly   988 MH---VAHSRQQQDEQQK----DNAH-THSQS---------QIQDQNHSQNQAIHNSMSQ--DPY 1033
            :|   ..||...:...:|    |..| .|:..         :|:.:|..:.:...:..|:  |..
Frog  1259 LHRDPALHSLASEGVDRKPVVCDMDHLMHNDGCTEERVATREIKKENIEEGEEEKDDSSKRCDSC 1323

  Fly  1034 SNLHT----TAMSPLGAFDEDADMDLELE--------SHDFDLVDPD-----EHGDTNDP 1076
            |:.||    |..|.:...||.|...::|:        |..:|.:.|.     .|.:..:|
Frog  1324 SSEHTLCCETDPSRMHREDEAAQHCVDLQRPHYLRRSSSFYDKLRPSSAHDCSHKEITNP 1383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_001259065.1	CUT	756..830	CDD:280527	33/77 (43%)
onecut	NP_001259065.1	HOX	920..975	CDD:197696	19/62 (31%)
cux2	NP_001128286.2	CUT	557..626	CDD:280527	12/73 (16%)
		CUT	899..972	CDD:280527	32/82 (39%)
		CUT	1049..1125	CDD:280527	11/75 (15%)
		Homeobox	1177..1230	CDD:278475	17/52 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910