Protein Alignment onecut and onecut2

DIOPT Version :10

• Sequence 1: NP_524842.2
• Gene: onecut / 45816
• FlyBaseID: FBgn0028996
• Length: 1081
• Species: Drosophila melanogaster
• Sequence 2: XP_001920308.3
• Gene: onecut2 / 100000073
• ZFINID: ZDB-GENE-120215-73
• Length: 461
• Species: Danio rerio
• Alignment Length: 831
• Identity: 231/831 - (27%)
• Similarity: 290/831 - (34%)
• Gaps: 410/831 - (49%)

  Fly   171 SKSQDQSHRRIRMLVDVSSVNSGLGVHVDDMDEISSDGVGCDDEGVTLSHQHLLEQEEQFGLTSH 235
            :|..|.......|.:|:.|:::|                        :||       ||..::||
Zfish    12 AKDLDAYAMNPEMTMDIGSLHAG------------------------VSH-------EQDLMSSH 45

  Fly   236 HPHLQPHTQIIHGLHQRS------THSEMGLDNGHGEVLSVIVHSQDSDKEDCEENDDGDAEGDL 294
            .||           |.|:      .|.::.:......::|.:....|.       ...|...|:.
Zfish    46 SPH-----------HSRNPGAALRIHQDLSVAPSRSAMVSSMASILDG-------GGGGGGGGEY 92

  Fly   295 ENEDDDERDSRSREQLLSHSSYQTLTSVNDRLSSPGFSQTSYATLTPIQPLPPISTMSEKFAYSG 359
            ..|             ||...:..::...| .|.||.|.| |.||||:||||||||:|:||.:..
Zfish    93 RPE-------------LSLPLHHAMSMPCD-TSPPGMSGT-YTTLTPLQPLPPISTVSDKFHHPH 142

  Fly   360 H--------ISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCS--NNDC 414
            |        :||..|                 |..|....|.|..       |.:::.|  :.|.
Zfish   143 HHHHHHHQRLSGNVS-----------------GSFTLMRDERTLP-------AMNNLYSPYHKDM 183

  Fly   415 SSFSALSMPIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVSCDLHSSVSGRVINSSHLQ 479
            |.......|:|:   |||.:...|              |..:||
Zfish   184 SGMGQSLSPLGN---GLGSIHSAQ--------------PTLHNY--------------------- 210

  Fly   480 LSHNGNKKESGTHEHTHRPADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDAN 544
                |:.|...::...|            |..:||||
Zfish   211 ----GHDKMLSSNFDAH------------TAMLSRGD---------------------------- 231

  Fly   545 REKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARG 609
                   .|:|.|..||......:...||:.         |..                 ||:.|
Zfish   232 -------QHLSRGLGGPAAGMMPHLNGMHAH---------PGH-----------------PPSHG 263

  Fly   610 SLSRHLAPNAPICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSP 674
                                                ||:.|                   .|..|
Zfish   264 ------------------------------------PVLAS-------------------NRDRP 273

  Fly   675 GHREQYFLDKSQEPSSVVADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKG 739
                                                           ..|||     |||.:|
Zfish   274 -----------------------------------------------LSSSS-----SSCGAP-- 284

  Fly   740 TVSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKP 804
                         .|..:||||||::||||:||||||||||||||||||||||||||||||||||
Zfish   285 -------------GSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKP 336

  Fly   805 WSKLKSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDL 869
            ||||||||||||||:|||||||||||||||:||
Zfish   337 WSKLKSGRETFRRMWKWLQEPEFQRMSALRLAA-------------------------------- 369

  Fly   870 DPHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKE-EPQIEQMPQPKKPRLVFTDLQRR 933
                                                |:||| :|..::...|||.||||||||||
Zfish   370 ------------------------------------CKRKEQDPSKDRSNTPKKSRLVFTDLQRR 398

  Fly   934 TLQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRSMDKWRDDDS 984
            ||.|||||.||||||||:||::|||||.:||.||||||||||:|||.|:.|
Zfish   399 TLLAIFKENKRPSKEMQMTISQQLGLELSTVSNFFMNARRRSLDKWLDEGS 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
onecut	NP_524842.2	CUT	756..830	CDD:460543	67/73 (92%)
		HOX	920..975	CDD:197696	45/54 (83%)
onecut2	XP_001920308.3	CUT	290..362	CDD:460543	67/71 (94%)
		HOX	385..440	CDD:197696	45/54 (83%)