DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn27A and SERPINB4

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	397	Identity:	123/397 - (30%)
Similarity:	201/397 - (50%)	Gaps:	34/397 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SDSHDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALLAEAAGAGTQTQV-------ELANTQT 127
            |:::..|.:.|.:..  .::.:.|:..||.|:...|.::...|...|..|:       ::....|
Human     5 SEANTKFMFDLFQQF--RKSKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTT 67

  Fly   128 D------IRSQNNVREFYRKTLNSFKKENQLHETLSVRTKLFTDSFIETQQKFTATLKHFYDSEV 186
            :      :....||...::|.|..|.|....:| |.:..|||.:...:..|::...:|.||.:.|
Human    68 EKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYE-LKIANKLFGEKTYQFLQEYLDAIKKFYQTSV 131

  Fly   187 EALDFTN-PEAAADAINAWAANITQGRLQQLVAPDNV--RSSVMLLTNLIYFNGLWRRQF--ATT 246
            |:.||.| ||.:...||:|..:.|..:::.|. ||..  ..:.::|.|.|||.|.|..:|  ..|
Human   132 ESTDFANAPEESRKKINSWVESQTNEKIKNLF-PDGTIGNDTTLVLVNAIYFKGQWENKFKKENT 195

  Fly   247 FQGSFFRSKDDQSRAEFMEQTDYFYYTTSEKLKAQILRLPYKGKN-SLFVLLPYALNGIHDLVKN 310
            .:..|:.:|:.....:.|.|.:.|.:...|.::|::|.:|||||: |:.||||..::|:..|.:.
Human   196 KEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEK 260

  Fly   311 LENDELKSAQWA----MEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDSASLPGLTRGADV 371
            |..::|  .:|.    |.|..|.:.||:|..:...:||:|||::|:..||...|.|.|:|....:
Human   261 LTAEKL--MEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGL 323

  Fly   372 AGKVKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGSTAIEEFNVNRPFVFFIEEESTGNILF 436
            :    ||.:|.||.:.|.|:|.||.|||.|.:......||. |||..|.||:|||.:..|.:|||
Human   324 S----VSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTN-EEFCCNHPFLFFIRQNKTNSILF 383

  Fly   437 AGKVHSP 443
            .|:..||
Human   384 YGRFSSP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	120/390 (31%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	121/395 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930