Protein Alignment Spn27A and SERPINI2

DIOPT Version :10

• Sequence 1: NP_652024.1
• Gene: Spn27A / 45815
• FlyBaseID: FBgn0028990
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: NP_006208.1
• Gene: SERPINI2 / 5276
• HGNCID: 8945
• Length: 405
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 102/373 - (27%)
• Similarity: 178/373 - (47%)
• Gaps: 40/373 - (10%)

  Fly    93 NVIISPFSVKLVLALLAEAAGAGTQTQVELANTQTDIRSQNNVRE--FYRKTLNSFKKENQLHET 155
            |:|.||..:.|||.::...|....|.|:.    ||..:.:.:..|  |..|:..|...|.:...|
Human    44 NIIFSPLGITLVLEMVQLGAKGKAQQQIR----QTLKQQETSAGEEFFVLKSFFSAISEKKQEFT 104

  Fly   156 LSVRTKLFTDSFIETQQKFTATLKHFYDSEVEALDFTNPEAAADAINAWAANITQGRLQQLVAPD 220
            .::...|:.......::::....|.|:.|.::.:||.:.:|.|:.|:.|....|.|:::.:.:.:
Human   105 FNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGE 169

  Fly   221 NVRS-SVMLLTNLIYFNGLWRRQFATTFQGSFFRSKDDQSRAEFME---------------QTDY 269
            .... :.::|.|.|||.|.|:::|          .|:|.....|.:               :|.|
Human   170 EFGPLTRLVLVNAIYFKGDWKQKF----------RKEDTQLINFTKKNGSTVKIPMMKALLRTKY 224

  Fly   270 FYYTTSEKLKAQILRLPYKGKN-SLFVLLPYALNGIHDLVKNLENDELKSAQWAMEEVKVKVTLP 333
            .|::.| .|..|:|.|.|||.. ||.::||.....|.::.|.:...::......|:|.:|:::||
Human   225 GYFSES-SLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLP 288

  Fly   334 KFHFDYQQNLKETLRSLGVREIFEDSASLPGLTRGADVAGKVKVSNILQKAGINVNEKGTEAYAA 398
            :|..:.:.:.|:.|.||.:.|||.....|.|:|..::    |.||.:.||....:||.|:||..:
Human   289 RFKVEQKVDFKDVLYSLNITEIFSGGCDLSGITDSSE----VYVSQVTQKVFFEINEDGSEAATS 349

  Fly   399 TVVEIENKFGGSTAIEEFNVNRPFVFFIEEESTGNILFAGKVHSPTTQ 446
            |.:.|....  |.|..:|..|.||:|.::...|.:|||.|:|.:|.||
Human   350 TGIHIPVIM--SLAQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQ 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_652024.1	serpinK_insect_SRPN2-like	64..443	CDD:381044	99/368 (27%)
SERPINI2	NP_006208.1	serpinI2_pancpin	23..392	CDD:381042	99/368 (27%)