DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn27A and serpina1

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	XP_017207927.1	Gene:	serpina1 / 322701	ZFINID:	ZDB-GENE-030131-1421	Length:	433	Species:	Danio rerio

Alignment Length:	399	Identity:	120/399 - (30%)
Similarity:	193/399 - (48%)	Gaps:	28/399 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PSGAGIYDDIDTFVPFRSDSHDPFSWHLLKTVLQN-ETADKNVIISPFSVKLVLALLAEAAGAGT 116
            ||..|: |......|..:|    |::.|.|.:..| :...||:..||..:.:.|:|||..|.|.|
Zfish    55 PSHKGV-DACHLLAPHNAD----FAFSLYKKLASNPDGQGKNIFFSPVGISMALSLLAVGAKAST 114

  Fly   117 QTQVELANTQTDIRSQNNVREFYRKTLNSF---KKENQLHETLSVRTKLFTDSFIETQQKFTATL 178
            .:|: .:.......:...|.|.|...|:..   :...||.....|..:   |.| :...:|....
Zfish   115 LSQI-YSGLGYSALTPEQVNEGYEHLLHMLGHSQDAMQLEAGAGVAIR---DGF-KVVDQFLKDA 174

  Fly   179 KHFYDSEVEALDFTNPEAAADAINAWAANITQGRLQQLVAPDNVRSSVMLLTNLIYFNGLWRRQF 243
            :|:|:||...:||:.||.||..||.:.|..|..::..:| .|....:||:|.|.:||.|.|.:.|
Zfish   175 QHYYNSEAFGVDFSKPEIAAAEINKFIARKTHDKITNMV-KDLDADTVMMLINYMYFRGKWEKPF 238

  Fly   244 --ATTFQGSFFRSKDDQSRAEFMEQTDYFYYTTSEKLKAQILRLPYKGKNSLFVLLPYALNG-IH 305
              ..|.:..|...:|...:.:.|::|..:........:..::.:||||..|:.::||.  :| :.
Zfish   239 DAKLTHKADFKVDQDTTVQVDMMKRTGRYDIYQDPVNQTTVMMVPYKGNTSMMIVLPD--DGKMK 301

  Fly   306 DLVKNLENDELKSAQWAMEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDSASLPGLTRGAD 370
            :|.:::....||:....:....|.:.:|||.......|...|:.:|:.:.|.|.|...|:|...
Zfish   302 ELEESICRHHLKNWHDKLFRSSVDLFMPKFSISATSKLDGILKDMGMTDAFNDKADFSGMTEEV- 365

  Fly   371 VAGKVKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGSTAIEEFNVNRPFVFFIEEESTGNIL 435
               |||||.:|.:|.::|:||||||.|.|.:||.......|.|    :||||:..|.|:||.:||
Zfish   366 ---KVKVSQVLHQAVMSVDEKGTEAAAITTIEIMPMSLPDTVI----LNRPFLVLIVEDSTMSIL 423

  Fly   436 FAGKVHSPT 444
            |.||:.:||
Zfish   424 FMGKITNPT 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	111/374 (30%)
serpina1	XP_017207927.1	alpha-1-antitrypsin_like	69..428	CDD:239011	112/378 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010