DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn27A and Serpinb1b

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	XP_038952280.1	Gene:	Serpinb1b / 306891	RGDID:	1560658	Length:	380	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	120/394 - (30%)
Similarity:	202/394 - (51%)	Gaps:	38/394 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SDSHDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALL-AEAAGAGTQTQVELANT-----QTD 128
            |.::..|:..|..|:  :|::....|.||||:...||:: ..|.|:...:.:.||.|     ..|
  Rat     5 SSANSLFALELFHTL--SESSPTGNIFSPFSISSALAMVFLGAKGSSAPSSLRLAETFHFDSVED 67

  Fly   129 IRSQNNVREFYRKTLNSFKKENQLHETLSVRTKLFTDSFIETQQKFTATLKHFYDSEVEALDFTN 193
            |.|:       .::||:..:::....||.|..:|:.:.......:|.|:.:..|.:::..:||.:
  Rat    68 IHSR-------FQSLNAEMRKHGASHTLKVANRLYGEKTYNFLPEFLASTQKMYGADLAPVDFQH 125

  Fly   194 -PEAAADAINAWAANITQGRLQQLVAPDNVRSSV-MLLTNLIYFNGLWRRQFAT--TFQGSFFRS 254
             .|.|...||.|....|:|::.:|:|...|.|:. ::|.|.|||.|:|:.:|.|  |....|..:
  Rat   126 ASEDARKEINKWVKGQTEGKIPELLAGGVVNSTTKLVLVNAIYFKGIWQEKFLTRHTTDAPFRLN 190

  Fly   255 KDDQSRAEFMEQTDYFYYTTSEKLKAQILRLPYK-GKNSLFVLLPYAL----NGIHDLVKNLEND 314
            |.|....:.|.|.:.|.:.....||.::|.:||: |:.|:.:|||..:    .|:..:.:.|..:
  Rat   191 KKDTKMVKMMYQKEKFPFGYIPDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLQKIEEQLTLE 255

  Fly   315 ELKSAQWA----MEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDS-ASLPGLTRGADVAGK 374
            :|  .:|.    ::|:.|.|.||||..:....|...|..||::::|..| |.|.|::...|:.
  Rat   256 KL--YEWTKHENLKEIDVHVNLPKFKIEESYILNSNLGRLGLQDLFSSSKADLSGMSESRDIF-- 316

  Fly   375 VKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGSTAIEEFNVNRPFVFFIEEESTGNILFAGK 439
              :|.|:.|:.:.|||:||||.|||...:|...   .:||.|.|:.||:|||....|.|:||.|:
  Rat   317 --ISKIVHKSFVEVNEEGTEAAAATAGLVEYCL---VSIEAFIVDHPFLFFIRHNPTANMLFFGR 376

  Fly   440 VHSP 443
            |.||
  Rat   377 VCSP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	116/387 (30%)
Serpinb1b	XP_038952280.1	serpinB1_LEI	1..380	CDD:381028	118/392 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.030