DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn27A and Serpina16

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_853661.2	Gene:	Serpina16 / 299271	RGDID:	727888	Length:	415	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	103/466 - (22%)
Similarity:	182/466 - (39%)	Gaps:	84/466 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAVMLLSLFLSALATGNGNSIPTTTTPQGVFETRTDKLPGGAASVPSGAGIYDDIDTFVPFRSDS 72
            :|:.:|||:|  |..|   .:|.:..||    |.........:.:|...|.       .||  .:
  Rat     1 MALSILSLWL--LLAG---LVPCSCDPQ----TPPPPEASNMSQIPVTQGA-------PPF--FN 47

  Fly    73 HDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALLA--EAAGAGTQTQVELANTQTDIRSQNNV 135
            :..|:..|.|.:.|.:.. ||:|.||..:.:.|.|||  :...|..|...:|..|.|........
  Rat    48 NQKFALSLYKQLPQPKRG-KNLIFSPLGIIVPLVLLAFQDKPKARHQVLQDLGFTVTGALDTKAA 111

  Fly   136 REFYRKTLNSFKKENQLHET---LSVRTKLFTDSFIETQQKFTATLKHFYDSEVEALDFTNPEAA 197
            .| |.|.|:     |.||..   :...:.||.|..::..:.|.......|:|.|..:.|.|...|
  Rat   112 SE-YGKLLS-----NLLHTKNCGIYTGSLLFIDKTLKPAKTFVKLANSSYNSNVVLISFGNYGLA 170

  Fly   198 ADAINAWAANITQGRLQQLV----APDNVRSSVMLLTNLIYFNGLWRRQF--ATTFQGSFFRSKD 256
            ...|:......|.|::.:|:    .|.|     :.|.|..:|.|.|:..|  ..|....|:....
  Rat   171 QKQIDLAIRARTHGKITKLLRILKPPTN-----LFLANYNFFKGKWKYPFNRKHTRMRYFWLEDG 230

  Fly   257 DQSRAEFMEQTDYFYYTTSEKLKAQILRLPYKGKNSLFVLLPYALNGIHDLVKNLENDELKSAQW 321
            .::....|::..:|......::.:.:|:||:....|....||             ::.:.:.::.
  Rat   231 TKTLVPMMQRVGWFQLQYFSQMHSYVLQLPFTCSISGVFFLP-------------DDGKFEESEK 282

  Fly   322 AMEEVKVKVTL------------PKFHFD---YQQNLKETLRSLGVREIFEDSASLPGLTRGADV 371
            |:.|...:..:            |||...   :.:|||....::   ::|.:...|..:|.   .
  Rat   283 ALLEQSFETWIQPFPMSKRWLFFPKFSIPVALHLENLKHVNSNI---KLFSEHMDLSRITL---Q 341

  Fly   372 AGKVKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGSTAIEEFNVNRPFVFFIEEESTGNILF 436
            ...:.||..:.:..:.|||.|.|         :::......:...:.||.|:..|.:|::.::||
  Rat   342 KAPLTVSTAVHRVELTVNEDGEE---------KDESQPEPDLATLHFNRSFLLLILDETSNSLLF 397

  Fly   437 AGKVHSPTTQN 447
            .|||.:||..|
  Rat   398 MGKVVNPTRIN 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	83/393 (21%)
Serpina16	NP_853661.2	serpinA16_HongrES1-like	40..406	CDD:381053	89/414 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100