DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn27A and Serpinb8

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001099418.1	Gene:	Serpinb8 / 288937	RGDID:	1309833	Length:	375	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	110/384 - (28%)
Similarity:	192/384 - (50%)	Gaps:	25/384 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DSHDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALLAEAAGAGTQTQVELANTQTDIRSQNNV 135
            :::..|:..||| :|..|...:|:...|.||...||::...|...|.||:   :....:....:|
  Rat     6 EANGSFAISLLK-ILGEEDKSRNLFFCPMSVSSALAMVYLGAKGNTATQM---SQVLGLSGDGDV 66

  Fly   136 REFYRKTLNSFKKENQLHETLSVRTKLFTDSFIETQQKFTATLKHFYDSEVEALDFT-NPEAAAD 199
            .:.::..|....|....: .|....:||.:...:....|..:.:.||.:.:|.:.|. :.|....
  Rat    67 HQGFQTLLAEVNKSGTQY-LLKSACRLFGEESCDFLSTFKESCQKFYQAGIEEMSFVKDTEGCRK 130

  Fly   200 AINAWAANITQGRLQQLVAPDNV-RSSVMLLTNLIYFNGLWRRQFATTF-QGSFFRSKDDQSR-A 261
            .||.|....|:|::.::::|..| ..:.::|.|.:||.|.|:.||...: :|..|::..::.: .
  Rat   131 RINDWVLEKTEGKISEVLSPGTVCPLTKLVLVNAMYFKGKWKAQFDRKYTRGMPFKTNQEEKKTV 195

  Fly   262 EFMEQTDYFYYTTSEKLKAQILRLPY-KGKNSLFVLLPYALNGIHDLVKNLENDELKSAQW---- 321
            :.|.:...|.....:::.||:|.||| :.:.|:.||||...:.:..:.|.|..::|::  |
  Rat   196 QMMFKHAKFKMAHVDEVNAQVLALPYAEDELSMVVLLPDESSDLTVVEKALTYEKLRA--WTNPE 258

  Fly   322 AMEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDS-ASLPGLTRGADVAGKVKVSNILQKAG 385
            .:.|.||:|..|:...:...:|:..|:|||:.:.||:: |...|:|...:    |.||.:..|..
  Rat   259 TLTESKVQVFFPRLKLEESYDLETVLQSLGMTDAFEETKADFSGMTSKKN----VPVSKVAHKCF 319

  Fly   386 INVNEKGTEAYAATVVEIENKFGGSTAIE-EFNVNRPFVFFIEEESTGNILFAGKVHSP 443
            :.|||:|||| |||...|.|.  .|..|| .|..:|||:|||..:.|.:|||.|:..||
  Rat   320 VEVNEEGTEA-AATTAVIRNT--RSCRIEPRFCADRPFLFFIWHQKTSSILFCGRFSSP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	108/378 (29%)
Serpinb8	NP_001099418.1	SERPIN	4..375	CDD:294093	108/382 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930