DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn27A and Serpina3f

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001028507.2	Gene:	Serpina3f / 238393	MGIID:	2182838	Length:	445	Species:	Mus musculus

Alignment Length:	389	Identity:	108/389 - (27%)
Similarity:	190/389 - (48%)	Gaps:	33/389 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SDSHDPFSWHLLK-TVLQNETADKNVIISPFSVKLVLALLAEAAGAGTQTQVELAN------TQT 127
            :.|:..|::.|.| .||:|  .|:||:.||||:...||||  :.||.:.|..|:..      |:|
Mouse    38 ASSNTDFAFSLYKELVLKN--PDENVVFSPFSICTALALL--SLGAKSNTLKEILEGLKFNLTET 98

  Fly   128 DIRSQNNVREFYRKTLNSFKKE-NQLHETLSVRTKLFTDSFIETQQKFTATLKHFYDSEVEALDF 191
               .:.::.:.:|..|:...:. ||:.  :|..:.||.:..::...:|....:..|.:|....||
Mouse    99 ---PEPDIHQGFRYLLDLLSQPGNQVQ--ISTGSALFIEKHLQILAEFKEKARALYQAEAFTADF 158

  Fly   192 TNPEAAADAINAWAANITQGRLQQLVAPDNVRSSVMLLTNLIYFNGLWRRQF--ATTFQGSFFRS 254
            ..|..|...||.:.:|.|||::::|:: |..:.::|:|.|.|||.|.|...|  ..|.:..|:..
Mouse   159 QQPLEATKLINDYVSNHTQGKIKELIS-DLDKRTLMVLVNYIYFKGKWEMPFDPDDTCKSEFYLD 222

  Fly   255 KDDQSRAEFME----QTDYFYYTTSEKLKAQILRLPYKGKNSLFVLLPYALNGIHDLVKNLENDE 315
            ::...:...|:    .|.||   ..|:|...::.|.|.|..|...:|| ....:..:..:|:.:.
Mouse   223 ENRSVKVPMMKINNLTTPYF---RDEELSCTVVELKYTGNASAMFILP-DQGKMQQVEASLQPET 283

  Fly   316 LKSAQWAMEEVKV-KVTLPKFHFDYQQNLKETLRSLGVREIFEDSASLPGLTRGADVAGKVKVSN 379
            |::.:.:::...: ::.||||......:|:..|..||:||:|...|.|..:|...|    ::.|.
Mouse   284 LRNWKDSLKPRLINELCLPKFSISTDYSLEHILPELGIRELFSTQADLSAITGTKD----LRTSQ 344

  Fly   380 ILQKAGINVNEKGTEAYAATVVEIENKFGGSTAIEEFNVNRPFVFFIEEESTGNILFAGKVHSP 443
            ::.||.::|.|.||||.|.|..:......|.....:...:|||:..|.:.:|...||..||.:|
Mouse   345 VVHKAVLDVAETGTEAAAGTGYQNLQCCQGVIYSMKIYFDRPFLMIISDTNTHIALFMAKVSNP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	105/382 (27%)
Serpina3f	NP_001028507.2	alpha-1-antitrypsin_like	40..405	CDD:239011	105/382 (27%)
Serpina3f	NP_001028507.2	RCL	357..382		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010