DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn27A and SRPN1

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	XP_308847.4	Gene:	SRPN1 / 1270171	VectorBaseID:	AGAP006909	Length:	421	Species:	Anopheles gambiae

Alignment Length:	424	Identity:	155/424 - (36%)
Similarity:	238/424 - (56%)	Gaps:	38/424 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ASVPSGAGIYD------DIDTFVPFR--SDSHDP-------FSWHLLKTVLQNETADKNVIISPF 99
            ::||:....|.      .|.|..|||  ...|.|       |.|:|.:.|.::|  |.||:.|||
Mosquito     3 SAVPNSVRCYAVLMLLISIGTVQPFRRHHPRHQPSFVSRSDFDWNLAREVFRHE--DSNVVFSPF 65

  Fly   100 SVKLVLALLAEAA--GAGTQTQVELANTQTDIRSQNNVREFYRKTLNSFKKENQLHETLSVRTKL 162
            |:||:|.||.|||  |:||::|:|.|....|:   |..|.||.:.|::.::.|..:| ..:.||:
Mosquito    66 SIKLLLTLLYEAAEPGSGTRSQLEAALVDPDL---NQTRAFYTQFLDASQQTNGDYE-FDIGTKM 126

  Fly   163 FTD-SFIETQQKFTATLKHFYDSEVEALDFTNPEAAADAINAWAANITQGRLQQLVAPDNVRSSV 226
            |.| :..:..|.:|..|:..|.:.||.:.|...:|.|:.||.|...:|:||:.:||..|.::.:.
Mosquito   127 FLDKARAKLPQAYTDLLEQMYRTSVERVSFNGTKATAERINTWCEKVTRGRITELVTEDTLQDAQ 191

  Fly   227 MLLTNLIYFNGLWRRQFA--TTFQGSFFRSKDDQSRAEFMEQTDYFYYTTSEKLKAQILRLPYKG 289
            ::|.|:::....|:..|.  .|...:|..:..|....|||.|.|.:.||..|:|.|::|||||||
Mosquito   192 LVLANVLFLKASWKNSFPDDQTHNRTFHVADGDTVTTEFMRQMDLYDYTVHEQLGAEVLRLPYKG 256

  Fly   290 KN-SLFVLLPY---ALNGIHDLVKNLENDELKSAQWAMEEVKVKVTLPKFHFDYQQNLKETLRSL 350
            :. |:.::||:   :|..:.|.:.....|.: :.|:..||  |.|.:|||.|:|...|.|.::.|
Mosquito   257 RQFSMNMVLPHRNVSLAALADALTPTMLDSI-AEQFVREE--VTVLIPKFRFNYGTLLNEAIQRL 318

  Fly   351 GVREIFEDSASLPGLTRGAD-----VAGKVKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGS 410
            |:|::|..:|:||.|....|     :..:|:||.:||||||.:|||||.|:|||.:::.||||..
Mosquito   319 GIRDVFTKNAALPLLASADDAKQSTIKNEVQVSKMLQKAGIEINEKGTLAFAATEIQLVNKFGYD 383

  Fly   411 TAIEEFNVNRPFVFFIEEESTGNILFAGKVHSPT 444
            .....|..||||:|:|.:|.|..|||.|||..|:
Mosquito   384 GEPIVFEANRPFLFYILDEETNAILFVGKVTDPS 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	144/388 (37%)
SRPN1	XP_308847.4	SERPIN	40..413	CDD:238101	142/381 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D140751at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49771
Panther	1	1.100	-	-	LDO	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890