DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn27A and SRPN3

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	XP_308846.4	Gene:	SRPN3 / 1270170	VectorBaseID:	AGAP006910	Length:	418	Species:	Anopheles gambiae

Alignment Length:	404	Identity:	140/404 - (34%)
Similarity:	217/404 - (53%)	Gaps:	45/404 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 FVPFRSDSHDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALLAEAAGAGTQTQVEL------A 123
            :.||....:|.|.|.::|.||..  |..|.:|||.|||.:||||.|.:.:.::|:.||      .
Mosquito    37 YEPFAGTWNDDFDWSVIKEVLHK--APGNAVISPLSVKALLALLYEGSASRSETERELQQALSGG 99

  Fly   124 NTQTDIRSQNNVREFYRKTLNSFKKENQLHETLSVRTKLFTDSFIETQQKFTATLKHFYDSEVEA 188
            |:|...:.|:::.::          :.|..:.|.:..::|.|:.:...||:.:.:...|::..::
Mosquito   100 NSQAVPKLQDDLLQY----------KQQQQQNLLITDRIFYDTTVTLLQKYHSIIAARYNATTQS 154

  Fly   189 LDFTNPEAAADAINAWAANITQGRLQQLVAPDNVRSSVMLLTNLIYFNGLWRRQFAT--TFQGSF 251
            :||.:.::||..||||.|..|:|::|.::.||.::.::|:|.|.|||.|.|...|.|  |.:..|
Mosquito   155 VDFQDTQSAAAEINAWIAQNTRGKIQSIIKPDLLQDALMMLINTIYFKGSWSIPFPTNATVERPF 219

  Fly   252 FRSK-------DDQSRAEFMEQTD-YFYYTTSEKLKAQILRLPYKGKN-SLFVLLPYALNGIHDL 307
            |..:       .......||:|.: .|||..:|:|.||.|||||.... |:.|:||.....:..|
Mosquito   220 FTGRMHTAGRYGGPRSVPFMKQRERIFYYKHAEQLGAQFLRLPYDSNQLSMIVVLPDEQVSLGQL 284

  Fly   308 VKNLENDELKSAQWAMEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDSASLPGLTRGADVA 372
            :..|..|.:......|.|.:|::.||:|...|..:|:|.|:.|||..:|.|.|.||.::||...
Mosquito   285 LSRLTADAVHETLADMSEEEVEIELPRFTITYSSSLRECLQQLGVSRVFTDQAELPLISRGRTT- 348

  Fly   373 GKVKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGS---TAIEE---FNVNRPFVFFIEEEST 431
             .:|||.||||:.|.|:|:||||.|||        .|:   |.:::   |..||||:|.|.:|..
Mosquito   349 -PLKVSTILQKSCILVDEQGTEASAAT--------EGTLVFTILDQPVKFIANRPFLFLIYDEGK 404

  Fly   432 GNILFAGKVHSPTT 445
            ||.||||||..|.|
Mosquito   405 GNWLFAGKVEDPQT 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	134/390 (34%)
SRPN3	XP_308846.4	SERPIN	45..413	CDD:238101	134/389 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D140751at6656
OrthoFinder	1	1.000	-	-		FOG0012746
OrthoInspector	1	1.000	-	-		otm49771
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.890