DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn27A and Serpinh1

DIOPT Version :9

Sequence 1:	NP_001260143.1	Gene:	Spn27A / 45815	FlyBaseID:	FBgn0028990	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001104513.1	Gene:	Serpinh1 / 12406	MGIID:	88283	Length:	417	Species:	Mus musculus

Alignment Length:	411	Identity:	94/411 - (22%)
Similarity:	173/411 - (42%)	Gaps:	44/411 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PGGAASVPSGAGIYDDIDTFVPFRSDSHDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALLAE 110
            ||.|..:.|.|....:..|.:.|.           |...:..:.|.:|:::||..|...|.|::.
Mouse    29 PGTAEKLSSKATTLAERSTGLAFS-----------LYQAMAKDQAVENILLSPLVVASSLGLVSL 82

  Fly   111 AAGAGTQTQVELANTQTDIRSQNNVREFYRKTLNSFKKENQLHETLSVRTKLFTDSFIETQQKFT 175
            ...|.|.:|.:...:...:|.: .|.....:.|.|.......:.|..:.::|:..|.:.....|.
Mouse    83 GGKATTASQAKAVLSAEKLRDE-EVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFV 146

  Fly   176 ATLKHFYDSEVEALDFTNPEAAADAINAWAANITQGRLQQLVAPDNVRSSVMLLTNLIYFNGLWR 240
            .:.|..|:.|...::|.:..:|..:||.||:..|.|:|.: |..|..|:...||.|.::|...|.
Mouse   147 RSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPE-VTKDVERTDGALLVNAMFFKPHWD 210

  Fly   241 RQF--ATTFQGSFFRSKDDQSRAEFMEQTDYFYYTTSEKLKAQILRLPYKGK-NSLFVLLPYALN 302
            .:|  .......|..::........|.:|..:.|...||.|.|::.:|...| :||.:|:|:.:.
Mouse   211 EKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVE 275

  Fly   303 GIHDLVKNLENDELKSAQWAMEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDSASLPGLTR 367
            .:..|.|.|..::||:....|::..|.::|||...:...:|::.|..||:.|..:.:
Mouse   276 PLERLEKLLTKEQLKAWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKN-------- 332

  Fly   368 GADVAGKVKVSNILQKAGINVNEKGTEAYAATVVEIE---NKFGGSTAIEE-------FNVNRPF 422
                  |..:|.:..|..:.:    ...:.||..|.:   |.|.......|       |..:.||
Mouse   333 ------KADLSRMSGKKDLYL----ASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPF 387

  Fly   423 VFFIEEESTGNILFAGKVHSP 443
            :|.:.:..:|::||.|::..|
Mouse   388 IFLVRDNQSGSLLFIGRLVRP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn27A	NP_001260143.1	SERPIN	72..440	CDD:238101	86/380 (23%)
Serpinh1	NP_001104513.1	serpinH1_CBP1	35..416	CDD:381003	91/405 (22%)
Serpinh1	NP_001104513.1	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920