DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlnRS and GLN4

DIOPT Version :9

Sequence 1:	NP_524841.1	Gene:	GlnRS / 45786	FlyBaseID:	FBgn0027090	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_014811.3	Gene:	GLN4 / 854339	SGDID:	S000005694	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	836	Identity:	326/836 - (38%)
Similarity:	458/836 - (54%)	Gaps:	93/836 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DDLIAKFQALGMSEQKAKETLKNANVTKNLQLSLAAAGSATLSD-----GTGMLIYHMATKLKPQ 63
            ::|...|..:|..::|.||.:||..|:.:|...:    ..|.||     .|..|::::|:.:|..
Yeast     5 EELTQLFSQVGFEDKKVKEIVKNKKVSDSLYKLI----KETPSDYQWNKSTRALVHNLASFVKGT 65

  Fly    64 TADHLPLLVRYIVEHKLDNTQRVDAALEYLLKCGQSLNANIDLQALEKECGVGVVVTPEQIERTV 128
            ......|:|..|:...|..:.:||||.:|:...|::...    ..:.:..|||:.:|.:|:...|
Yeast    66 DLPKSELIVNGIINGDLKTSLQVDAAFKYVKANGEASTK----MGMNENSGVGIEITEDQVRNYV 126

  Fly   129 QAKIKASYKEALLEQRYHFNSFKILQDVRG--ELKWADAKSVKAAIDVEIFDLLGPKTEADL-KP 190
            ...|:.: ||.:|.:||.... .|..||:.  ||||||.:|.|..||.|:..|||||.|.|| |.
Yeast   127 MQYIQEN-KERILTERYKLVP-GIFADVKNLKELKWADPRSFKPIIDQEVLKLLGPKDERDLIKK 189

  Fly   191 QTKANDKPKAAKPKAEVTPAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVVTEHTE-- 253
            :||.|:|.|           ..:|:.:||.:.: |...:|..:     |.|..|.:.|.|:.:
Yeast   190 KTKNNEKKK-----------TNSAKKSSDNSAS-SGPKRTMFN-----EGFLGDLHKVGENPQAY 237

  Fly   254 -RLLKEHLARTGGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKF 317
             .|:||||..|||||.|||||||||.|||||:|||.:|||||..|:|.||||:||||||||..::
Yeast   238 PELMKEHLEVTGGKVRTRFPPEPNGYLHIGHSKAIMVNFGYAKYHNGTCYLRFDDTNPEKEAPEY 302

  Fly   318 FLAIKEMVEWLGYKPFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELK---GFNPKPSP-- 377
            |.:||.||.|||:||:|||||||.|.:||..|.|||..|.|||||..|||:|   |.....:|
Yeast   303 FESIKRMVSWLGFKPWKITYSSDYFDELYRLAEVLIKNGKAYVCHCTAEEIKRGRGIKEDGTPGG 367

  Fly   378 ------WRERPIEESLRLFEDMKRGKIDEGAATLRMKVTLEEGK---MDPVAYRIKFISHHRTGS 433
                  .|::.||::|:.|.||:.||...|.|.||||..|....   .|.:|||:....|.|||:
Yeast   368 ERYACKHRDQSIEQNLQEFRDMRDGKYKPGEAILRMKQDLNSPSPQMWDLIAYRVLNAPHPRTGT 432

  Fly   434 DWCIYPTYDYTHCLCDSLEDITHSLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVS 498
            .|.||||||:||||.||:|:|||||||.||...|.||.|||:.:.::.|.|.||||||:...::|
Yeast   433 KWRIYPTYDFTHCLVDSMENITHSLCTTEFYLSRESYEWLCDQVHVFRPAQREYGRLNITGTVLS 497

  Fly   499 KRKIAKLITEQIVHDWDDPRLFTLTALRRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDV 563
            |||||:|:.|:.|..|||||||||.|:||||.|..||.:|...:|||.:...:.....|:|||..
Yeast   498 KRKIAQLVDEKFVRGWDDPRLFTLEAIRRRGVPPGAILSFINTLGVTTSTTNIQVVRFESAVRKY 562

  Fly   564 LNVTAPRRLVVLEPLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLE-PE 627
            |..|.||.:.||:|::|.:.|..........:|..|..|:.|...:......|||:.||... .:
Yeast   563 LEDTTPRLMFVLDPVEVVVDNLSDDYEELATIPYRPGTPEFGERTVPFTNKFYIERSDFSENVDD 627

  Fly   628 KGYRRLAPKQSVGLRHAGLVISVDEIVKDPATGQVVELICT----SQPAEQAEKPKAFVQWV--- 685
            |.:.||.|.|.|||......:|...:.||.| |:::.:...    .:...:.:|||.::|||
Yeast   628 KEFFRLTPNQPVGLIKVSHTVSFKSLEKDEA-GKIIRIHVNYDNKVEEGSKPKKPKTYIQWVPIS 691

  Fly   686 ---SQPIQL-EVRLYEQLFKHKNPEDPNEVPGGFLSDISEQSMSVVVA------FADRALNQAKV 740
               :.|::: |.|:|.||||.:|   |:..|.|||.||:.:|..|...      |.|...|...|
Yeast   692 SKYNSPLRVTETRVYNQLFKSEN---PSSHPEGFLKDINPESEVVYKESVMEHNFGDVVKNSPWV 753

  Fly   741 YD-------------------KFQFERIGFFSVDPDTSANHLVFNRTVGLKEDAGK 777
            .|                   :||..|:|:|::|.:::.:.::.||.|.||:...|
Yeast   754 VDSVKNSEFYVEEDKDSKEVCRFQAMRVGYFTLDKESTTSKVILNRIVSLKDATSK 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	324/828 (39%)
GLN4	NP_014811.3	tRNA_synt_1c_R1	5..163	CDD:398315	47/167 (28%)
		tRNA_synt_1c_R2	166..244	CDD:398314	30/94 (32%)
		glnS	252..807	CDD:273079	239/558 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343871
Domainoid	1	1.000	333	1.000	Domainoid score	I169
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3704
Inparanoid	1	1.050	519	1.000	Inparanoid score	I194
Isobase	1	0.950	-	0	Normalized mean entropy	S750
OMA	1	1.010	-	-		QHG60878
OrthoFinder	1	1.000	-	-		FOG0002938
OrthoInspector	1	1.000	-	-		oto100125
orthoMCL	1	0.900	-	-		OOG6_101072
Panther	1	1.100	-	-	LDO	PTHR43097
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1454
SonicParanoid	1	1.000	-	-		X2299
TreeFam	1	0.960	-	-
	16	15.740