Protein Alignment GlnRS and GLN4

DIOPT Version :10

• Sequence 1: NP_524841.1
• Gene: GlnRS / 45786
• FlyBaseID: FBgn0027090
• Length: 778
• Species: Drosophila melanogaster
• Sequence 2: NP_014811.3
• Gene: GLN4 / 854339
• SGDID: S000005694
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 836
• Identity: 326/836 - (38%)
• Similarity: 458/836 - (54%)
• Gaps: 93/836 - (11%)

  Fly     4 DDLIAKFQALGMSEQKAKETLKNANVTKNLQLSLAAAGSATLSD-----GTGMLIYHMATKLKPQ 63
            ::|...|..:|..::|.||.:||..|:.:|...:    ..|.||     .|..|::::|:.:|..
Yeast     5 EELTQLFSQVGFEDKKVKEIVKNKKVSDSLYKLI----KETPSDYQWNKSTRALVHNLASFVKGT 65

  Fly    64 TADHLPLLVRYIVEHKLDNTQRVDAALEYLLKCGQSLNANIDLQALEKECGVGVVVTPEQIERTV 128
            ......|:|..|:...|..:.:||||.:|:...|::...    ..:.:..|||:.:|.:|:...|
Yeast    66 DLPKSELIVNGIINGDLKTSLQVDAAFKYVKANGEASTK----MGMNENSGVGIEITEDQVRNYV 126

  Fly   129 QAKIKASYKEALLEQRYHFNSFKILQDVRG--ELKWADAKSVKAAIDVEIFDLLGPKTEADL-KP 190
            ...|:.: ||.:|.:||.... .|..||:.  ||||||.:|.|..||.|:..|||||.|.|| |.
Yeast   127 MQYIQEN-KERILTERYKLVP-GIFADVKNLKELKWADPRSFKPIIDQEVLKLLGPKDERDLIKK 189

  Fly   191 QTKANDKPKAAKPKAEVTPAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVVTEHTE-- 253
            :||.|:|.|           ..:|:.:||.:.: |...:|..:     |.|..|.:.|.|:.:
Yeast   190 KTKNNEKKK-----------TNSAKKSSDNSAS-SGPKRTMFN-----EGFLGDLHKVGENPQAY 237

  Fly   254 -RLLKEHLARTGGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKF 317
             .|:||||..|||||.|||||||||.|||||:|||.:|||||..|:|.||||:||||||||..::
Yeast   238 PELMKEHLEVTGGKVRTRFPPEPNGYLHIGHSKAIMVNFGYAKYHNGTCYLRFDDTNPEKEAPEY 302

  Fly   318 FLAIKEMVEWLGYKPFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELK---GFNPKPSP-- 377
            |.:||.||.|||:||:|||||||.|.:||..|.|||..|.|||||..|||:|   |.....:|
Yeast   303 FESIKRMVSWLGFKPWKITYSSDYFDELYRLAEVLIKNGKAYVCHCTAEEIKRGRGIKEDGTPGG 367

  Fly   378 ------WRERPIEESLRLFEDMKRGKIDEGAATLRMKVTLEEGK---MDPVAYRIKFISHHRTGS 433
                  .|::.||::|:.|.||:.||...|.|.||||..|....   .|.:|||:....|.|||:
Yeast   368 ERYACKHRDQSIEQNLQEFRDMRDGKYKPGEAILRMKQDLNSPSPQMWDLIAYRVLNAPHPRTGT 432

  Fly   434 DWCIYPTYDYTHCLCDSLEDITHSLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVS 498
            .|.||||||:||||.||:|:|||||||.||...|.||.|||:.:.::.|.|.||||||:...::|
Yeast   433 KWRIYPTYDFTHCLVDSMENITHSLCTTEFYLSRESYEWLCDQVHVFRPAQREYGRLNITGTVLS 497

  Fly   499 KRKIAKLITEQIVHDWDDPRLFTLTALRRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDV 563
            |||||:|:.|:.|..|||||||||.|:||||.|..||.:|...:|||.:...:.....|:|||..
Yeast   498 KRKIAQLVDEKFVRGWDDPRLFTLEAIRRRGVPPGAILSFINTLGVTTSTTNIQVVRFESAVRKY 562

  Fly   564 LNVTAPRRLVVLEPLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLE-PE 627
            |..|.||.:.||:|::|.:.|..........:|..|..|:.|...:......|||:.||... .:
Yeast   563 LEDTTPRLMFVLDPVEVVVDNLSDDYEELATIPYRPGTPEFGERTVPFTNKFYIERSDFSENVDD 627

  Fly   628 KGYRRLAPKQSVGLRHAGLVISVDEIVKDPATGQVVELICT----SQPAEQAEKPKAFVQWV--- 685
            |.:.||.|.|.|||......:|...:.||.| |:::.:...    .:...:.:|||.::|||
Yeast   628 KEFFRLTPNQPVGLIKVSHTVSFKSLEKDEA-GKIIRIHVNYDNKVEEGSKPKKPKTYIQWVPIS 691

  Fly   686 ---SQPIQL-EVRLYEQLFKHKNPEDPNEVPGGFLSDISEQSMSVVVA------FADRALNQAKV 740
               :.|::: |.|:|.||||.:|   |:..|.|||.||:.:|..|...      |.|...|...|
Yeast   692 SKYNSPLRVTETRVYNQLFKSEN---PSSHPEGFLKDINPESEVVYKESVMEHNFGDVVKNSPWV 753

  Fly   741 YD-------------------KFQFERIGFFSVDPDTSANHLVFNRTVGLKEDAGK 777
            .|                   :||..|:|:|::|.:::.:.::.||.|.||:...|
Yeast   754 VDSVKNSEFYVEEDKDSKEVCRFQAMRVGYFTLDKESTTSKVILNRIVSLKDATSK 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	324/828 (39%)
GLN4	NP_014811.3	tRNA_synt_1c_R1	5..163	CDD:461353	47/167 (28%)
		tRNA_synt_1c_R2	166..244	CDD:461352	30/94 (32%)
		glnS	252..807	CDD:273079	239/558 (43%)