DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlnRS and eprs1

DIOPT Version :9

Sequence 1:	NP_524841.1	Gene:	GlnRS / 45786	FlyBaseID:	FBgn0027090	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_009291485.1	Gene:	eprs1 / 562037	ZFINID:	ZDB-GENE-030131-638	Length:	1690	Species:	Danio rerio

Alignment Length:	773	Identity:	198/773 - (25%)
Similarity:	319/773 - (41%)	Gaps:	168/773 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GSATLS--DGTGMLIYHMATKLKPQTADHLPLLVRYIV----------EHKLDNTQRVDAALEYL 93
            ||..||  :|...:: |::.::  |.:| :..:.||:.          .:.::.|: ||..||:.
Zfish    25 GSVNLSVEEGKDTML-HVSDQV--QFSD-VNSITRYLARVAPALGLYGSNMMEQTE-VDHWLEFS 84

  Fly    94 LK--CGQSLNANIDLQALEKECG-----VGVVVTPEQIERTVQAKIKASYKE------------- 138
            .:  |||| :.:..|..|:|...     ||..||...:  .:.|.:|.:.:.
Zfish    85 ARRLCGQS-DLSSALADLDKALALRTFLVGRSVTLADL--CIWAALKGNGESQAKPSSHPHLCRW 146

  Fly   139 -ALLEQRYHFNSFKILQDVRGELKWADAKSVKAAIDVEIFDLLGPKTEADLKPQTKANDKPKAAK 202
             :.|..:..|:|.       |. |||...|...|..||               :.|..|..|..:
Zfish   147 FSFLSSQVPFSSV-------GS-KWASKVSASKAASVE---------------KDKKQDLGKFVE 188

  Fly   203 -PKAEVTPAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVVTEHTERLLKEHLARTGGK 266
             |.||:                                                         ||
Zfish   189 LPGAEM---------------------------------------------------------GK 196

  Fly   267 VHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKFFLAIKEMVEWLGYK 331
            |..|||||.:|.||||||||..:|..|.....|...:|:||||||||:|.|...|.|.|..|..|
Zfish   197 VVVRFPPEASGYLHIGHAKAALLNQHYQVTFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLQIK 261

  Fly   332 PFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPKPSPWRER--PIEESLRLFEDMK 394
            |.:.||:||:|..:......|:.:|.||:.....:.:|....:.:..|.|  .:|::::::|:||
Zfish   262 PDQFTYTSDHFPTILRMGEKLLQEGKAYIDDTPPDIMKQEREQRAESRNRNNSVEKNMQMWEEMK 326

  Fly   395 RGKIDEGAATLRMKVTLEEGK---MDPVAYRIKFISHHRTGSDWCIYPTYDYTHCLCDSLEDITH 456
            :|........:|.|:.:....   .||..:|.|..:|.|||:.:.:|||||:...:.||:|.:||
Zfish   327 KGTEFGQTCCMRAKIDMNSNNGCLRDPALFRCKNAAHPRTGTTYKVYPTYDFACPIVDSIEGVTH 391

  Fly   457 SLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIAKLITEQIVHDWDDPRLFT 521
            :|.|.|:..|...:||:..|||:..|..|||.|||:|..::||||:...:.:..|..|||||..|
Zfish   392 ALRTTEYHDRDEQFYWVIEALGLRKPYIWEYARLNLNNTVLSKRKLTWFVDKGYVDGWDDPRFPT 456

  Fly   522 LTALRRRGFPAEAINNFCAQMGVTGAQIAVD---------PAMLEAAVRDVLNVTAPRRLVVLE- 576
            :..:.|||...:.:..|.|..|  |::..|:         ...|..:.:.|::..|||...:|.
Zfish   457 VRGVLRRGMTVDGLKQFIAAQG--GSRSVVNMEWDKIWAFNKKLPVSCKKVIDPVAPRFTALLSS 519

  Fly   577 ---PLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQS 638
               |:.|:     .|.....|||..|:|...|..::.....::||..|.:...|        .:.
Zfish   520 QVIPVCVS-----EAKETMKEVPKHPKNADVGLKQVWYGPKVFIEGADAETFTE--------GEI 571

  Fly   639 VGLRHAGLVISVDEIVKDPATGQVVELICTSQPAEQAEKPKAFVQWVSQPIQLE------VRLYE 697
            |...:.|.:| :.:|.:| ::|.::.|...........|....:.|:::..:..      |....
Zfish   572 VTFINWGNII-ITKIHRD-SSGAILSLDGHLNLENTDYKKTTKITWLAESSRASFVPTVCVNYQH 634

  Fly   698 QLFKHKNPEDPNEVPGGFLSDISEQSMSVVVAFADRALNQAKVYDKFQFERIGFFSVD 755
            .:.|....:|.:     |...|::.|........|..|...|..|..|.:|.||:..|
Zfish   635 LITKPVLGKDDD-----FKDYINKNSKIEEKMIGDPCLKDLKKGDIIQLQRRGFYICD 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	198/773 (26%)
eprs1	XP_009291485.1	PLN02907	1..717	CDD:215492	198/773 (26%)
		GST_C_GluProRS_N	73..153	CDD:198342	19/83 (23%)
		tRNA-synt_1c	196..497	CDD:279135	109/302 (36%)
		tRNA-synt_1c_C	510..687	CDD:281883	40/196 (20%)
		Med25_SD1	716..901	CDD:288132
		WEPRS_RNA	762..811	CDD:238473
		WHEP-TRS	841..892	CDD:278865
		WEPRS_RNA	911..960	CDD:238473
		WEPRS_RNA	996..1045	CDD:238473
		WHEP-TRS	1080..1132	CDD:278865
		PRK08661	1197..1690	CDD:236327
		ProRS_core_arch_euk	1201..1464	CDD:238401
		ProRS_anticodon_zinc	1470..1690	CDD:238439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820