DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlnRS and GluProRS

DIOPT Version :9

Sequence 1:	NP_524841.1	Gene:	GlnRS / 45786	FlyBaseID:	FBgn0027090	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_524471.2	Gene:	GluProRS / 42834	FlyBaseID:	FBgn0005674	Length:	1714	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	213/786 - (27%)
Similarity:	325/786 - (41%)	Gaps:	150/786 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KAKETLKNANVTKNLQLSLAAAGSATLSDGT-------------------GMLIYHMATKLKPQT 64
            |.|..|.|.        .::...:|.|.:||                   .:|:.|       ..
  Fly     4 KLKANLNNP--------PISGLATAHLINGTVPVEIVWSKEETSLQFPDNRLLVCH-------SN 53

  Fly    65 ADHLPLLVRYIVEHKL------DNTQRVDAALEYLLKCGQSLNANIDLQALEKECGVGVVVTPEQ 123
            .|.|..|.|...::||      :.|| :|..|.:.|.|...:  :..|..|:|.      :.|
  Fly    54 NDVLRALARAAPDYKLYGETAIERTQ-IDHWLSFSLTCEDDI--SWALSFLDKS------IAP-- 107

  Fly   124 IERTVQAKIK----ASYKEALLEQRYHFNSFK-ILQDVRGELKWADAKSVKAAIDVEIFDLLGPK 183
            :...|..|:.    |.:.|  :..||.|.:.| |.|.|:   :|.|..:.:..|.         |
  Fly   108 VTYLVANKLTIADFALFNE--MHSRYEFLAAKGIPQHVQ---RWYDLITAQPLIQ---------K 158

  Fly   184 TEADLKPQTKANDKPKAAKPKAEVTPAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVV 248
            ....|....|....|:::|   |.|| |:|.|...:|.           ....||...
  Fly   159 VLQSLPEDAKVKRSPQSSK---EQTP-AKTGERKQEGK-----------FVDLPGAEM------- 201

  Fly   249 TEHTERLLKEHLARTGGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKE 313
                            |||..|||||.:|.||||||||..:|..||.|..|...:|:|||||.||
  Fly   202 ----------------GKVVVRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNPAKE 250

  Fly   314 EEKFFLAIKEMVEWLGYKPFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPK--PS 376
            ..:|...|...:|.|..||...|::|:.|..:.::.|.||.:..|||.....|::|....:  .|
  Fly   251 TVEFENVILGDLEQLQIKPDVFTHTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLEREQRVES 315

  Fly   377 PWRERPIEESLRLFEDMKRGKIDEGAATLRMKVTLE--EGKM-DPVAYRIKFISHHRTGSDWCIY 438
            ..|...:|::|.|:|:|.:|........:|.|:.:.  .|.| ||..||.|...|.|||:.:.:|
  Fly   316 ANRSNSVEKNLSLWEEMVKGSEKGQKYCVRAKIDMSSPNGCMRDPTIYRCKNEPHPRTGTKYKVY 380

  Fly   439 PTYDYTHCLCDSLEDITHSLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIA 503
            ||||:...:.|::|::||:|.|.|:..|...:||..:||.:..|..|.|.||||...::||||:.
  Fly   381 PTYDFACPIVDAIENVTHTLRTTEYHDRDDQFYWFIDALKLRKPYIWSYSRLNMTNTVLSKRKLT 445

  Fly   504 KLITEQIVHDWDDPRLFTLTALRRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDVLNVTA 568
            ..:...:|..|||||..|:..:.|||...|.:..|....|.:.:.:.::...:.|..:.|::..|
  Fly   446 WFVDSGLVDGWDDPRFPTVRGIIRRGMTVEGLKEFIIAQGSSKSVVFMNWDKIWAFNKKVIDPIA 510

  Fly   569 PRRLVVLEPLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRL 633
            | |...||..|..|.|...|...:::|...|::...|...:.|...|||:..|.:...|......
  Fly   511 P-RYTALEKEKRVIVNVAGAKVERIQVSVHPKDESLGKKTVLLGPRIYIDYVDAEALKEGENATF 574

  Fly   634 APKQSVGLRH-----AGLVISVDEIV----KD-PATGQVVELICTSQPAEQAEKPKAFVQW---- 684
            ....::.:|.     :|.:.|||..:    || ..|.::..|.....|:..   |..|..:
  Fly   575 INWGNILIRKVNKDASGNITSVDAALNLENKDFKKTLKLTWLAVEDDPSAY---PPTFCVYFDNI 636

  Fly   685 VSQPIQLEVRLYEQLFKHKNPEDPNEVPGGFLSDISEQSMSVVVAFADRALNQAKVYDKFQFERI 749
            :|:.:..:...::|...||..:   |||                ...|..|.:.|..|..|.:|.
  Fly   637 ISKAVLGKDEDFKQFIGHKTRD---EVP----------------MLGDPELKKCKKGDIIQLQRR 682

  Fly   750 GFFSVD 755
            |||.||
  Fly   683 GFFKVD 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	213/786 (27%)
GluProRS	NP_524471.2	PLN02907	1..715	CDD:215492	213/786 (27%)
		GST_C_GluProRS_N	76..153	CDD:198342	23/92 (25%)
		tRNA-synt_1c	203..508	CDD:279135	110/304 (36%)
		tRNA-synt_1c_C	510..688	CDD:281883	46/200 (23%)
		WHEP-TRS	748..799	CDD:278865
		WHEP-TRS	821..870	CDD:278865
		WHEP-TRS	894..945	CDD:278865
		WEPRS_RNA	973..1022	CDD:238473
		WHEP-TRS	1050..1100	CDD:278865
		WHEP-TRS	1122..1168	CDD:278865
		PRK08661	1220..1714	CDD:236327
		ProRS_core_arch_euk	1224..1486	CDD:238401
		ProRS_anticodon_zinc	1492..1714	CDD:238439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750