DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlnRS and Qars1

DIOPT Version :9

Sequence 1:	NP_524841.1	Gene:	GlnRS / 45786	FlyBaseID:	FBgn0027090	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_001007625.1	Gene:	Qars1 / 290868	RGDID:	1359448	Length:	775	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	452/788 - (57%)
Similarity:	565/788 - (71%)	Gaps:	25/788 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGDDLIAKFQALGMSEQKAKETLKNANVTKNLQLSLAAA----GSATLSDGTGMLIYHMATKLK 61
            ||..|.:|.|..||:||.||:||||||.::..|:.:...|    || |:...||.|:|.:|::|:
  Rat     1 MATPDSLALFTGLGLSENKARETLKNAALSTQLREAATQAQQTLGS-TIDKATGTLLYGLASRLR 64

  Fly    62 PQTADHLPLLVRYIVEHKLDNTQRVDAALEYLLKCGQSLNANIDLQALEKECGVGVVVTPEQIER 126
              ....|..||.||...|:....::.|||||:.  ...|:. ||.:..|:||||||||||||||.
  Rat    65 --DTRRLSFLVGYIANKKIHTELQLSAALEYVR--SHPLDP-IDTKDFEQECGVGVVVTPEQIEE 124

  Fly   127 TVQAKIKASYKEALLEQRYHFNSFKILQDVRGELKWADAKSVKAAIDVEIFDLLGPKTEADLKPQ 191
            .|:|.|. .::..||.:||.|:...::.:.|..|:|||.|.:|..:|:::..|||||.||||:
  Rat   125 AVEATIN-RHRPQLLVERYRFSMGLLMGEARAALRWADGKMIKNEVDMQVLHLLGPKMEADLE-- 186

  Fly   192 TKANDKPKAAKPKAEVT------PAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVVTE 250
                .|||.||.:.|.|      ...:..|.|....:.:.:|....:.||.||||:|..|||.|.
  Rat   187 ----KKPKVAKARLEETDRKTAKDVVENGEVAGQTLSLMEQLRGEALKFHKPGENYKTPGYVTTP 247

  Fly   251 HTERLLKEHLARTGGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEE 315
            ||..|||:||..|||:|.||||||||||||||||||||.|||||.|::|:|:||:|||||||||.
  Rat   248 HTMDLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEA 312

  Fly   316 KFFLAIKEMVEWLGYKPFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPKPSPWRE 380
            |||.||.:||.||||.|:|:||:||.|.|||.|||.||.:|.||||||:.|||||.||.|||||:
  Rat   313 KFFTAIYDMVTWLGYTPYKVTYASDYFDQLYAWAVELIRRGQAYVCHQRGEELKGHNPLPSPWRD 377

  Fly   381 RPIEESLRLFEDMKRGKIDEGAATLRMKVTLEEGKMDPVAYRIKFISHHRTGSDWCIYPTYDYTH 445
            |||||||.|||.|::||..||.||||||:.:|:|||||||||:|:..|||||..|||||||||||
  Rat   378 RPIEESLLLFEAMRKGKFAEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTH 442

  Fly   446 CLCDSLEDITHSLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIAKLITEQI 510
            |||||:|.|||||||||||:|||||:||||||.:||||||||||||::||:||||||.:|:....
  Rat   443 CLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVAAGA 507

  Fly   511 VHDWDDPRLFTLTALRRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDVLNVTAPRRLVVL 575
            |.|||||||||||||||||||.||||||||::|||.||..::|.:|||.||||||.||||.:.||
  Rat   508 VRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVL 572

  Fly   576 EPLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQSVG 640
            |||:|.|.|||...|:.:.||:||.:..:|.|::.....::||:.|||.|.|.||:|||..|.||
  Rat   573 EPLQVVITNFPAPKPLDIRVPNFPADETKGFHQVPFASTVFIERTDFKEESEPGYKRLAWGQPVG 637

  Fly   641 LRHAGLVISVDEIVKDPATGQVVELICTSQPAEQAEKPKAFVQWVSQPIQLEVRLYEQLFKHKNP 705
            |||.|.||.:..:|:. ::|.|..|..|.:.|:..||||||:.|||||:..|:||||:||:||||
  Rat   638 LRHTGYVIELQHVVRG-SSGCVECLEVTCRRADAGEKPKAFIHWVSQPLVCEIRLYERLFQHKNP 701

  Fly   706 EDPNEVPGGFLSDISEQSMSVVV-AFADRALNQAKVYDKFQFERIGFFSVDPDTSANHLVFNRTV 769
            |||.|||||||||::..|:.|:. |..|.::..||.:|||||||:|:||||||:....:||||||
  Rat   702 EDPVEVPGGFLSDLNPASLQVIKGALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGQVVFNRTV 766

  Fly   770 GLKEDAGK 777
            .||||.||
  Rat   767 TLKEDPGK 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	446/777 (57%)
Qars1	NP_001007625.1	GlnS	2..774	CDD:332033	449/785 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335610
Domainoid	1	1.000	499	1.000	Domainoid score	I336
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	905	1.000	Inparanoid score	I356
OMA	1	1.010	-	-		QHG60878
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	1	1.000	-	-		FOG0002938
OrthoInspector	1	1.000	-	-		otm46115
orthoMCL	1	0.900	-	-		OOG6_101072
Panther	1	1.100	-	-	O	PTHR43097
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910