DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlnRS and EPRS1

DIOPT Version :9

Sequence 1:	NP_524841.1	Gene:	GlnRS / 45786	FlyBaseID:	FBgn0027090	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_004437.2	Gene:	EPRS1 / 2058	HGNCID:	3418	Length:	1512	Species:	Homo sapiens

Alignment Length:	563	Identity:	181/563 - (32%)
Similarity:	273/563 - (48%)	Gaps:	49/563 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 EVTPAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVVTEHTERLLKEHLARTGGKVHTR 270
            |...|.|:.....|.:||     |.:|   ||.:......:|.....|.          |||..|
Human   155 EAQQAFQSVGTKWDVSTT-----KARV---APEKKQDVGKFVELPGAEM----------GKVTVR 201

  Fly   271 FPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKFFLAIKEMVEWLGYKPFKI 335
            ||||.:|.||||||||..:|..|.....|...:|:||||||||:|.|...|.|.|..|..||.:.
Human   202 FPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQF 266

  Fly   336 TYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPK--PSPWRERPIEESLRLFEDMKRGKI 398
            ||:||:|:.:.::|..||.:|.|||....||::|....:  .|..|:.|||::|:::|:||:|..
Human   267 TYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIDSKHRKNPIEKNLQMWEEMKKGSQ 331

  Fly   399 DEGAATLRMKVTLEEGK---MDPVAYRIKFISHHRTGSDWCIYPTYDYTHCLCDSLEDITHSLCT 460
            ...:..||.|:.:....   .||..||.|...|.|||:.:.:|||||:...:.||:|.:||:|.|
Human   332 FGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRT 396

  Fly   461 KEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIAKLITEQIVHDWDDPRLFTLTAL 525
            .|:..|...:||:..||||..|..|||.|||:|..::||||:...:.|.:|..|||||..|:..:
Human   397 TEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGV 461

  Fly   526 RRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDVLNVTAPRRLVVLEPLKVTIKNFPHAAP 590
            .|||...|.:..|.|..|.:.:.:.::...:.|..:.|::..|||.:.:|:...:.: |.|.|..
Human   462 LRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPV-NVPEAQE 525

  Fly   591 VQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQSVGLRHAGLVISVDEIVK 655
            ...||...|:||:.|...:.....::||..|.:...|        .:.|...:.| .:::.:|.|
Human   526 EMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAETFSE--------GEMVTFINWG-NLNITKIHK 581

  Fly   656 DPATGQVVELICTSQPAEQAEKPKAFVQWVSQ-----PIQLEVRLYEQLFKHK---NPEDPNEVP 712
            : |.|:::.|........:..|....|.|:::     ||.:....||.|....   ..||
Human   582 N-ADGKIISLDAKLNLENKDYKKTTKVTWLAETTHALPIPVICVTYEHLITKPVLGKDED----- 640

  Fly   713 GGFLSDISEQSMSVVVAFADRALNQAKVYDKFQFERIGFFSVD 755
              |...:::.|....:...|..|...|..|..|.:|.|||..|
Human   641 --FKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICD 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	181/563 (32%)
EPRS1	NP_004437.2	PLN02907	13..711	CDD:215492	181/563 (32%)
		GST_C_GluProRS_N	74..157	CDD:198342	1/1 (100%)
		Glutamate--tRNA ligase	164..759		178/554 (32%)
		tRNA-synt_1c	197..502	CDD:279135	122/304 (40%)
		'HIGH' region	204..214		6/9 (67%)
		'KMSKS' region	432..436		1/3 (33%)
		tRNA-synt_1c_C	504..681	CDD:281883	45/194 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..744
		WHEP-TRS	753..805	CDD:278865
		3 X 57 AA approximate repeats	760..956
		WHEP-TRS	826..878	CDD:278865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..900
		WEPRS_RNA	904..952	CDD:238473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..1012
		Charged	959..991
		Proline--tRNA ligase	1007..1512
		PRK08661	1019..1512	CDD:236327
		ProRS_core_arch_euk	1023..1286	CDD:238401
		L-proline binding. /evidence=ECO:0000269\|PubMed:24100331, ECO:0007744\|PDB:4K87	1121..1123
		ProRS_anticodon_zinc	1292..1512	CDD:238439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820